A comparative study of the in vitro permeation of 2-phenoxyethanol in the skin PAMPA model and mammalian skin

Rahma, Annisa; Lane, Majella E.; Sinkó, Bálint

doi:10.1016/j.ijpharm.2023.122692

Cited by 4 publications

(3 citation statements)

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“…These systems attracted the attention of researchers as high-throughput assays for the preliminary screening and for obtaining permeation-and stability-related insights into topical and transdermal formulations [14,15]. For example, this model has been exploited by Rahma and colleagues [16] for the assessment of the permeation of phenoxyethanol, a common preservative ingredient in baby wipe formulations; notably, the authors observed a positive correlation for the total amount of permeated phenoxyethanol between this artificial membrane and porcine or human skin placed in a Franz diffusion cell, a widely used system to test drug permeation in vitro [16][17][18]. A skin PAMPA was also used to assess the penetration of retinol with the addition of natural jojoba oil as a penetration enhancer: interesting data were obtained on the transdermal delivery capability of jojoba oil since the retinol permeation registered was nearly 40-fold greater when associated with the oil, probably due to its ability to increase the fluidity of the lipid barrier [19].…”

Section: Artificial Membranesmentioning

confidence: 99%

Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account?

Galvan,

Pellicciari,

Calderan

2024

IJMS

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Skin plays crucial roles in the human body: besides protecting the organism from external threats, it acts as a thermal regulator, is responsible for the sense of touch, hosts microbial communities (the skin microbiota) involved in preventing the invasion of foreign pathogens, contains immunocompetent cells that maintain a healthy immunogenic/tolerogenic balance, and is a suitable route for drug administration. In the skin, four defense levels can be identified: besides the physical, chemical, and immune barriers that are inherent to the tissue, the skin microbiota (i.e., the numerous microorganisms living on the skin surface) provides an additional barrier. Studying the skin barrier function or the effects of drugs or cosmetic agents on human skin is a difficult task since snapshot evidence can only be obtained using bioptic samples where dynamic processes cannot properly be followed. To overcome these limitations, many different in vitro models of human skin have been developed that are characterized by diverse levels of complexity in terms of chemical, structural, and cellular composition. The aim of this review is to summarize and discuss the advantages and disadvantages of the different human skin models so far available and to underline how the insertion of a proper microbiota would positively impact an in vitro human skin model in an attempt to better mimic conditions in vivo.

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Section: Artificial Membranesmentioning

confidence: 99%

Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account?

Galvan,

Pellicciari,

Calderan

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…9,10 Different types of skin, including PAMPA membrane, porcine skin, rat skin, and human skin, exhibit significant differences in permeability. 11,12 Results of experiments on the permeation of 2-phenoxyethanol (PE) indicate that the PAMPA membrane has much higher permeability compared to others. The permeation rates of porcine and rat skin are higher than human skin.…”

Section: Introductionmentioning

confidence: 99%

“…Currently, the primary method for investigating drug skin permeability is through in vivo/in vitro testing. However, these tests are costly and time-consuming, and the data is susceptible to variations in experimental procedures, skin types, and differences between laboratories. , Different types of skin, including PAMPA membrane, porcine skin, rat skin, and human skin, exhibit significant differences in permeability. , Results of experiments on the permeation of 2-phenoxyethanol (PE) indicate that the PAMPA membrane has much higher permeability compared to others. The permeation rates of porcine and rat skin are higher than human skin.…”

Section: Introductionmentioning

confidence: 99%