A Comparative Study of the Status of Oxidative Stress in Pregnant Nigerian Women

Idonije, O. B.; Festus, O.; Okhiai, O; Akpamu, U

doi:10.3923/rjog.2011.28.36

Cited by 14 publications

(13 citation statements)

References 29 publications

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“…Numerous studies have demonstrated higher concentrations of lipid peroxidation products in healthy pregnant women than in non-pregnant women (Uotila et al 1991, Qanungo et al 2000, Toescu at al 2002, Djordjevic et al 2004, Hung et al 2010, Idonije et al 2011. Some authors have found that plasma concentrations of TBARS and other markers of lipid peroxidation gradually increase during pregnancy, reaching the highest values in the third trimester (Carine et al 1993, Djordjevic et al 2004, Hung et al 2010), but other authors have reported that levels of the products of lipid peroxidation reach their maximum concentrations in the second trimester and then decline until term (Uotila et al 1991, Qanungo et al 2000.…”

Section: Discussionmentioning

confidence: 99%

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Szczubiał¹,

Kankofer²,

Dąbrowski³

et al. 2015

Polish Journal of Veterinary Sciences

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The aim of the study was to investigate oxidative stress during normal pregnancy in female dogs based on an evaluation of plasma markers for lipid and protein peroxidation. Twenty clinically healthy female dogs (10 non-pregnant and 10 pregnant) were used in the study. Blood samples from the pregnant animals were collected at 19-21, 38-40, and 56-58 days of pregnancy. Blood samples from non-pregnant female dogs were obtained between 20 and 35 days after ineffective breeding. As indicators of oxidative stress, we measured the following using spectrophotometric and spectrofluorimetric methods: thiobarbituric acid reactive substances (TBARS), radical cations of N,N, diethylpara-phenylene diamine (RC-DEPPD), sulfhydryl groups (SH groups), bityrosine and formylkynurenine. The mean plasma TBARS concentration in the pregnant dogs (0.486 ± 0.071 -0.581 ± 0.191 μmol/g protein) was significantly higher (p<0.05) than that found in the non-pregnant animals (0.274 ± 0.111 μmol/g protein). A marked, although not significant, decrease in SH group content, as well as an increase in bityrosine and formylkynurenine concentration were concurrently observed in the pregnant dogs. No significant differences were found in terms of the studied markers in the pregnant animals when comparing the values obtained during the investigated periods of pregnancy, although there was a progressive decrease in TBARS concentration and a progressive increase in RC-DEPPD, bityrosine and formylkynurenine contents. Our findings suggest that normal pregnancy in female dogs is associated with oxidative stress. Further studies are necessary to establish the physiological ranges of antioxidative/oxidative profiles in pregnant dogs and to explain if and how the intensity of oxidative stress might contribute to the risk of the complications of pregnancy.

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Section: Discussionmentioning

confidence: 99%

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Szczubiał¹,

Kankofer²,

Dąbrowski³

et al. 2015

Polish Journal of Veterinary Sciences

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“…The placental is rich in mitochondria and poly unsaturated fatty acids (PUFFAs); therefore, it favors the development of oxidative stress because numerous metabolic and respiratory processes take place to provide nutrients and oxygen for the developing foetus. Previous studies have shown increased oxidative stress in uncomplicated pregnancy compared with levels in non-pregnant women [5][6][7], and anaemia in pregnancy [8]. The latter evaluated some oxidative stress markers in 50 anaemic pregnant women and 25 non-pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Association of Total Antioxidant Status with Severity of Anaemia in Pregnancy in Ogun state, Nigeria

Emokpae¹,

Adesina²

2017

JMD

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Anaemia in pregnancy is a global public health challenge and contributes to increased generation of free radicals and decreased antioxidant status of pregnant women. This study evaluates the level of total antioxidant status (TAS) in uncomplicated pregnancy and its relationship with the levels of anemia severity in pregnant women.. Full blood count and total antioxidant status (TAS) were determined in 1200 pregnant women recruited from three health institutions in Shagamu, Ijebu Ode and Abeokuta in Ogun State, Nigeria. Total antioxidant status was analyzed using reagent supplied by Randox Laboratories, Crumlin, England while full blood count was assayed using Coulter counter cell dye auto-analyzed by Abott diagnostics (Wiesbaden, Germany). The demographic and clinical history was obtained using structured questionnaire. The levels of the measured variables were compared between anaemic and non-anaemic pregnant women while TAS was correlated with the severity of anaemia. Total antioxidant status was significantly lower (p<0.001) in anaemic than non-anaemic pregnant women. Among the anaemic pregnant women with normal levels of TAS, 92(46.9%) had mild anaemia, 100(51.0%) had moderate while 4(2.0 %) had severe anaemia. Out of those with abnormal TAS, 228(69.9%) had mild, 94(28.8%) had moderate, and 4(1.6%) had severe. A total of 196 anaemic pregnant women had normal TAS while abnormal low levels were observed among 326 anaemic pregnant women. The levels of TAS correlated significantly with anaemia severity from mild anaemia (r=0.128;p=0.05) to moderate anaemia (r=0.237;p=0.02) while insignificant correlation was observed among subjects with severe anaemia (r=0.321;p=0.6). . Pregnancy care should be organized in order to prevent anaemia and reduce free radical generation and maintain adequate antioxidant status of women to avoid complications.

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“…En gestantes adultas se ha informado aumento de los niveles plasmáticos de lípidos y de peroxidación lipídica, así como también disminución de ciertos antioxidantes (4)(5)(6). Sin embargo, existe poca información en gestantes adolescentes aun cuando su vulnerabilidad biológica es acentuada por la doble carga que impone el crecimiento fetal y el propio, existiendo evidencias de competencia entre madre y feto por los nutrientes (7).…”

Section: Introductionunclassified

Estudio exploratorio de marcadores plasmáticos del estado redox y perfil lipídico en gestantes adolescentes atendidas en una consulta prenatal pública de la ciudad de San Felipe, Venezuela

Ruíz-Fernández¹,

Osuna²,

Mora³

et al. 2016

Rev Med Hered

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RESUMENLas adolescentes embarazadas constituyen un grupo de alta vulnerabilidad biológica y social. Objetivo: Evaluar el comportamiento de marcadores plasmáticos del estado redox y perfil lipídico en gestantes adolescentes en el segundo y tercer trimestre de embarazo atendidas en una consulta prenatal pública y compararlo con el que muestran gestantes adultas y mujeres no embarazadas. Material y métodos: Estudio descriptivo transversal, que incluyó 29 gestantes adolescentes (14-20 años), 26 gestantes adultas (20-44 años) y 25 mujeres no embarazadas (17-44 años). Se determinó en suero malondialdehído (MDA), ácido ascórbico (AA), ácido úrico (AU), colesterol total (CT), LDLc, HDLc, triglicéridos (TGL) y se calculó el índice de estrés oxidativo (MDA/AA), relaciones CT/ HDLc, LDLc/HDLc, TGL/HDLc y colesterol NoHDL. Resultados: En ambos trimestres, las gestantes adolescentes mostraron valores más elevados de MDA, índice MDA/AA, TGL y relación TGL/HDLc así como concentraciones menores de AA, en comparación con adolescentes no embarazadas. Solo en el tercer trimestre, los niveles de CT y LDLc de las gestantes adolescentes superaron significativamente los encontrados en adolescentes no embarazadas. Los marcadores evaluados no variaron significativamente entre el segundo y tercer trimestre en las gestantes adolescentes. En el tercer trimestre, las concentraciones de MDA, LDLc y colesterol NoHDL de las gestantes adolescentes fueron significativamente menores respecto de las gestantes adultas. Conclusiones: El embarazo adolescente normal se asoció a modificaciones del estado redox y del metabolismo lipídico, especialmente en el tercer trimestre, pero no se confirmó que dichos cambios gestacionales fuesen de mayor magnitud respecto de las gestantes adultas.PALABRAS CLAVE: adolescente, embarazo, oxidación, ácido ascórbico, lípidos, ácido úrico. (Fuente: DeCS BIREME).

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A Comparative Study of the Status of Oxidative Stress in Pregnant Nigerian Women

Cited by 14 publications

References 29 publications

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs

Association of Total Antioxidant Status with Severity of Anaemia in Pregnancy in Ogun state, Nigeria

Estudio exploratorio de marcadores plasmáticos del estado redox y perfil lipídico en gestantes adolescentes atendidas en una consulta prenatal pública de la ciudad de San Felipe, Venezuela

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