“…An important effect of DNP and other uncouplers (or inhibitors) of oxidative phosphorylation is to slow down the mitochondrial accumulation of Ca2+, the mechanism by which the intracellular Ca2+ concentration is normally kept at a very low level (Lehninger et al 1967;Carafoli, Patriarca & Rossi, 1969;Caswell, 1969;Glagoleva, Liberman & Khashaev, 1970;Lust & Robinson, 1970). Uncouplers and possibly other metabolic inhibitors may thus produce a rapid rise in cytoplasmic-free Ca2+.…”