A Comparative Study of the Effect of Prednisolone and Celecoxib on MMO (Maximum Mouth Opening) and Pain Following Removal of Impacted Mandibular Third Molars

Abstract

Objective The purpose of this study was to compare the effects of prednisolone and celecoxib on pain and maximum mouth opening (MMO) after surgical removal of mandibular third molars. Methods and Materials This double-blind clinical study was conducted upon 60 subjects. These patients received 4 tablets of either 100 mg celecocxib or 5 mg prednisolone: one tablet before surgery and the rest for every 8 h postoperation. The subjects were asked to take acetaminophen codeine as rescue dose. Interincisal distance of upper and lower central teeth and pain measurements (according to Visual Analogue Scale) were taken before surgery, 24 h, 48 h and 7 days after surgery. Results Average pain intensity in 24 h after surgery in patients receiving celecoxib was 3.6 ± 2.5 with significant difference to the other group (p = 0.041), but in subsequent evaluations prednisolone group reported less pain intensity, but the differences were not significant. MMO in 48 h after surgery was lower in prednisolone group (p = 0.640) and in further evaluations the groups were almost similar. Analyzing the data revealed no significant difference between groups in MMO. Conclusion According to this study there is no significant difference in the effects of prednisolone or celecoxib upon MMO, while celecoxib had better results for pain relief in 24 h after surgery in comparison to prednisolone.

A Randomized Case-controlled Clinical Trial of the Effect of Preemptive Etoricoxib, Prednisolone and a Control Group on of Postoperative Sequelae after Surgical Removal of Impacted Mandibular Third Molars

“…There have been many surveys investigating the influence of administration of NSAIDs or glucocorticoid drugs on post-operative inflammation, but as a result of differences in inflammation assessment, prescriptive drugs, patterns of administration and provided dose, the comparison between the results is rather difficult. (9) Age, sex between the three groups: Patients in the age range between (20-30) represent the highest percentage in this study which is in keeping with Breik and Grubor (10) , in 2008, Hashemipour et al (11) , in 2013 who found that most patients in their study were in the third decade of life.…”

“…The results of this study showed that the highest level of pain for all three groups was seen in the 2nd day of operation, after that the pain scoretended to decline with time till the seventh day and a significant difference between the days within each group confirming that the maximumpain intensity occur within first 24 hrs after operation. Since pain starts with thetermination of local anesthesia with peak level in (6)(7)(8)(9)(10)(11)(12) hrs after surgicaloperation (20) , and it persists for about two to three days, thenits intensity gradually decreases till the 7th postoperative day (21) , so in this study the pain was measured from the first day ofoperation throughout 7 days.…”

Effectiveness of Different Routes of Corticosteroid Administration on Postoperative Complications Associated With Impacted Mandibular Third Molar Surgical Extraction (A Randomized Controlled Clinical Trial)

“…By palpating and identifying the inferior border, the vertical measurement was taken as the distance from the outer canthus of the eye to the angle of the jaw. (11) The facial measurement was calculated as: Horizontal measurement + vertical measurement / 2.…”

Best Practices for Management of Pain, Swelling, Nausea, and Vomiting in Dentoalveolar Surgery

“…They Drew found no difference in trismus; however, pain was better controlled with preemptive celecoxib. 30 …”