A comparative study of systems used for dynamic focusing of ultrasound

Sarvazyan, Armen; Fillinger, Laurent; Гаврилов, Л. Р.

doi:10.1134/s1063771009040198

Cited by 25 publications

(15 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A wide range of ultrasound exposure parameters like frequency, pulse duration and repetition, duty factor, and different commercially available microbubbles were explored to begin optimization of the desired effect. Further information on the TRA electronic system and results on studies can be found in [23, 39, 40–45, 51–56]. …”

Section: Methodsmentioning

confidence: 99%

Time-reversal Techniques in Ultrasound-assisted Convection-enhanced Drug Delivery to the Brain: Technology Development and In Vivo Evaluation

Lewis

Guarino

Gandhi

et al. 2011

Proceedings of Meetings on Acoustics

View full text Add to dashboard Cite

We describe a drug delivery method that combines Time-Reversal Acoustics (TRA) with Convection-Enhanced Delivery (CED) to improve the delivery of therapeutics to the interstitium of the brain. The Ultrasound-assisted CED approach (UCED) circumvents the blood-brain barrier by infusing compounds through a cannula that is inserted into the brain while simultaneously delivering ultrasound to improve the penetration of pharmaceuticals. CED without ultrasound-assistance has been used to treat a variety of neural disorders, including glioblastoma multiforme, a malignancy that presents a very poor prognosis for patients. We describe a novel system that is used to infuse fluids into the brain parenchyma while simultaneously exposing the tissue to safe levels of 1-MHz, low intensity, ultrasound energy. The system includes a combined infusion needle-hydrophone, a 10-channel ultralow-output impedance amplifier, a broad-band ultrasound resonator, and MatLab®-based TRA control and user-interface. TRA allows easy coupling of ultrasound therapy through the skull without complex phase-correction and array design. The smart targeting UCED system has been tested in vivo and results show it provides 1.5-mm spatial resolution for UCED and improves tracer distribution in the brain over CED alone.

show abstract

Section: Methodsmentioning

confidence: 99%

Time-reversal Techniques in Ultrasound-assisted Convection-enhanced Drug Delivery to the Brain: Technology Development and In Vivo Evaluation

Lewis

Guarino

Gandhi

et al. 2011

Proceedings of Meetings on Acoustics

View full text Add to dashboard Cite

show abstract

“…These investigators operated their virtual array in both transmit and receive (RX) modes 17 and used it to build a balloon catheter for arterial fibrillation. 18 Despite the proof of concept amply demonstrated in fluid media, TRCC-based virtual arrays developed to date [10][11][12][13][14][15][16][17][18] seem to have limited applicability in NDE. The reason is twofold.…”

Section: Introductionmentioning

confidence: 96%

“…13 Their 3-D imaging probe was used to obtain surface images of tissue phantoms in water. Sarvazyan and co-workers [14][15][16][17][18] also conducted a series of studies in a similar vein, employing an ergodic reverberator that consists of a water-filled plastic container partially surrounded by air. These investigators operated their virtual array in both transmit and receive (RX) modes 17 and used it to build a balloon catheter for arterial fibrillation.…”

Section: Introductionmentioning

confidence: 96%

Two-dimensional virtual array for ultrasonic nondestructive evaluation using a time-reversal chaotic cavity

Choi

Lee

Hong

et al. 2011

The Journal of the Acoustical Society of America

View full text Add to dashboard Cite

Despite its introduction more than a decade ago, a two-dimensional ultrasonic array remains a luxury in nondestructive evaluation because of the complexity and cost associated with its fabrication and operation. This paper describes the construction and performance of a two-dimensional virtual array that solves these problems. The virtual array consists of only two transducers (one each for transmit and receive) and an aluminum chaotic cavity, augmented by a 10 × 10 matrix array of rectangular rods. Each rod, serving as an elastic waveguide, is calibrated to emit a collimated pulsed sound beam centered at 2.5 MHz using the reciprocal time reversal. The resulting virtual array is capable of pulse-echo interrogation of a solid sample in direct contact along 10 × 10 scan lines. Three-dimensional imaging of an aluminum test piece, the nominal thickness of which is in the order of 1 cm, is successfully carried out using the virtual array.

show abstract

“…Sarvazyan et al 17. proposed a leaky cavity which is made of a crumpled plastic bottle filled with water and partially suspended in air.…”

mentioning

confidence: 99%

A compact time reversal emitter-receiver based on a leaky random cavity

Luong

Hies

Ohl

2016

Sci Rep

View full text Add to dashboard Cite

Time reversal acoustics (TRA) has gained widespread applications for communication and measurements. In general, a scattering medium in combination with multiple transducers is needed to achieve a sufficiently large acoustical aperture. In this paper, we report an implementation for a cost-effective and compact time reversal emitter-receiver driven by a single piezoelectric element. It is based on a leaky cavity with random 3-dimensional printed surfaces. The random surfaces greatly increase the spatio-temporal focusing quality as compared to flat surfaces and allow the focus of an acoustic beam to be steered over an angle of 41°. We also demonstrate its potential use as a scanner by embedding a receiver to detect an object from its backscatter without moving the TRA emitter.

show abstract

A comparative study of systems used for dynamic focusing of ultrasound

Cited by 25 publications

References 18 publications

Time-reversal Techniques in Ultrasound-assisted Convection-enhanced Drug Delivery to the Brain: Technology Development and In Vivo Evaluation

Time-reversal Techniques in Ultrasound-assisted Convection-enhanced Drug Delivery to the Brain: Technology Development and In Vivo Evaluation

Two-dimensional virtual array for ultrasonic nondestructive evaluation using a time-reversal chaotic cavity

A compact time reversal emitter-receiver based on a leaky random cavity

Contact Info

Product

Resources

About