A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients

Haznecî, Ersoy; Karabulut, Aysun Bay; Öztürk, Çetin; Batçıoğlu, Kadir; Doğan, Gürsoy; Karaca, Şemsettin; Eşrefoğlu, Muammer

doi:10.1111/j.1365-4632.2004.02027.x

Cited by 69 publications

(62 citation statements)

References 31 publications

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“…Hazneci et al [14] also reported SOD activity was significantly higher in active Vitiligo patient as compared to healthy controls. This suggests that there is an imbalance in the oxidant-antioxidant system (oxidative stress) due to disease activity resulting in high level of blood superoxide dismutase level.…”

Section: Resultsmentioning

confidence: 91%

Study of Oxidative Stress in Vitiligo

et al. 2010

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Vitiligo is an idiopathic, acquired, circumscribed, hypomelanotic skin disorder, characterized by milky white patches of different sizes and shapes. It is due to the destruction of melanocytes resulting in the absence of pigment production of the skin and mucosal surfaces. Oxidative stress has been implicated in pathophysiology of vitiligo. To study the activity of blood Superoxide dismutase (SOD) and Glutathione peroxidase (GPx) in vitiligo patients. A case-control study was conducted in which 100 patients were enrolled after written consent. 50 cases were of active vitiligo and 50 served as control (25 healthy control and 25 with stable vitiligo). SOD-In our study, among the active vitiligo cases 90% had high level of SOD and 10% had normal level of SOD. Among the stable vitiligo controls, 92% had normal level of SOD and 8% had low levels of SOD.The difference between active vitiligo cases and stable vitiligo control as well as with healthy control was statistically significant (P value \ 0.05). GPx-Among the active vitiligo cases 74% had normal GPx levels, 22% had low and only 4% had high levels of GPx. Among the stable vitiligo controls, 64% had normal GPx levels, 16% had low, and 20% had high levels of GPx. The difference between active vitiligo cases and stable vitiligo control as well as with healthy control was statistically not significant (P value [ 0.05). Our study shows that oxidative stress is involved in the pathophysiology of vitiligo, as indicated by the high levels of serum superoxide dismutase activity.

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Section: Resultsmentioning

confidence: 91%

Study of Oxidative Stress in Vitiligo

et al. 2010

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“…Levels of superoxide dismutase, glutathione peroxidase and malondialdehyde are significantly increased in vitiligo skin 40 , thus strengthening the concept of free-radical damage. Hazneci et al 41 also found evidence in support of oxidative stress in vitiligo.…”

Section: Lerner's Theory Of Self-destructionmentioning

confidence: 84%

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Arianayagam

Ryan

2016

Current Science

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Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte -melanocyte unit, or as with the synapses of the neurological system. There are other roles, biochemical and mechanical, of melanocyte. Management that is inclusive of a maximally holistic approach justifies the use of diverse herbals, yoga and concern for cultural awareness provided by integrated medicine. Vitiligo provides a model which demonstrates that Ayurveda has a richer view of its presentations, possibly a stronger line on its pathogenesis, and a huge range of herbals, many now backed by studies from ethnobotanical laboratories, awaiting research into the many possible mechanisms by which they may act in the wide and complex field of melanocyte biochemistry.

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“…Albinism or hypopigmentation is accompanied by a high level of erythrocyte-superoxide dismutase (SOD) activity, a marked reduction of catalase activity and the accumulation of excess H2O2, and NO generation as seen in patients with vitiligo [51][52][53], and the occurrence of a lipoperoxidative process in albino rabbits [3,4]. Previously we reported that cells in haploid frogs are more susceptible to oxidative stress compared to cells in diploid and triploid frogs [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

“…Several investigations have shown that breakdown in the oxidant-antioxidant balance plays a role in the development of an acquired pigment loss disorder, or vitiligo [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Skin Pigmentary Variants in <i>Rana Nigromaculata</i>

Tazawa

Okumoto

Kashiwagi

2006

J. Clin. Biochem. Nutr.

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Summary Because there is mounting evidence to suggest that oxidative stress is involved in the pathophysiology of albinism, albino amphibians are useful tools for studies on imbalances in the oxidant-antioxidant system. In the course of maintaining albino mutant frog strains it was found that crosses between albino males and heterozygous females of Rana nigromaculata sometimes produce offspring displaying pigmentary mosaicism. After hatching hypopigmented portions appear on the left or right side of the body, and this is accompanied by such abnormalities as poor viability, asymmetrical curvature of the body toward the hypopigmented side, and limb deformity. Histological examination of mosaics showed the cells of various tissues (except kidney) to be smaller on the hypopigmented side and larger on the pigmented side compared to corresponding cells in wild type offspring. Cytogenetic analysis of cultured skin cells revealed that wild type and albino individuals were diploidal with 26 chromosomes, the same as normal R. nigromaculata. In mosaics on the other hand, cells of hypopigmented portions were almost exclusively haploidal with 13 chromosomes, while pigmented portions were a mixture of roughly 75% triploidal, 39 chromosome cells and roughly 25% haploidal, 13 chromosome cells.

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A comparative study of superoxide dismutase, catalase, and glutathione peroxidase activities and nitrate levels in vitiligo patients

Abstract: Our study confirms that oxidative stress is involved in the pathophysiology of vitiligo, as indicated by the high levels of erythrocyte superoxide dismutase activity and plasma nitrite/nitrate.

Cited by 69 publications

References 31 publications

Study of Oxidative Stress in Vitiligo

Study of Oxidative Stress in Vitiligo

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Skin Pigmentary Variants in <i>Rana Nigromaculata</i>

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