A comparative study of skin blood flow in musculocutaneous and random pattern flaps

Gottrup, Finn; Oredsson, Sven; Price, David C.; Mathes, Stephen J.; Höhn, D.

doi:10.1016/0022-4804(84)90211-7

Cited by 16 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, oxygen tension, as well as leukocyte activation, have been demonstrated at a higher level in muscle flaps. [12][13][14] The extensive studies mentioned above on flapmediated wound healing did not address growth factors as important players in the healing process. Although many studies have been performed on the clinical effects of flaps in complex wounds, little is known about their capability as producers of growth factors.…”

Section: Discussionmentioning

confidence: 99%

Significant Angiogenic Potential is Present in the Microenvironment of Muscle Flaps in Humans

Vogt

Boorboor

Vaske

et al. 2005

J reconstr Microsurg

View full text Add to dashboard Cite

The purpose of this study was to determine the presence of growth factors and the quality of angiogenic potential in the wound microenvironment in different types of flaps in humans. The wound exudates from 23 flaps were processed for analysis of transforming growth factor beta1 (TGF-beta1), epidermal growth factor (EGF), interleukin 1alpha (IL-1alpha), platelet-derived growth factor-AB (PDGF-AB), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF-1) by enzyme-linked immunosorbent assay (ELISA) or radio immuno assay (RIA). Angiogenic activity of wound fluid from latissimus flaps was determined by thymidine incorporation in porcine microendothelial cells exposed to various concentrations of wound fluid and control media. Angiogenic and matrix growth factors were altered in a linear fashion during the wound-healing process. Regression analysis provided evidence for decreasing levels of PDGF and EGF for latissimus flaps. Also, statistically significant differences of growth factor levels were found for paired comparison of flap types at different times after operation. Growth of in-vitro endothelial cells was stimulated most by 10 percent wound fluid, compared to any of the individual recombinant angiogenic factors or combinations of these factors. The data suggest that vascularized tissue flaps will promote wound healing by providing sufficient sources of growth factors in the wound environment. The particular type of flap, i.e., muscle or fasciocutaneous flap, does not seem to have an impact on growth-factor expression.

show abstract

Section: Discussionmentioning

confidence: 99%

Significant Angiogenic Potential is Present in the Microenvironment of Muscle Flaps in Humans

Vogt

Boorboor

Vaske

et al. 2005

J reconstr Microsurg

View full text Add to dashboard Cite

show abstract

“…Another possible explanation for the beneficial effect of the delay phenomenon is altered microcirculatory flow from denervation [19,20]. Finally, tissue wounding in and of itself has an effect on tissue vascularity that is not specifically related to flap ischemia [21,22].…”

Section: Discussionmentioning

confidence: 99%