A Comparative Study of Short Course Ciprofloxacin Treatment in Typhoid and Paratyphoid Fever

Nelwan, R.H.H.; Hendarwanto,; Zulkarnain, Iskandar; Gunawan, Julianti; Supandiman, Iman; Yusuf, Harmas Yazid; Soedjana, P.; Syahroni, A.

doi:10.2165/00003495-199500492-00136

Cited by 8 publications

(2 citation statements)

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“…Almost all studies with its stereoisomer counterpart that is known as ofloxacin gave excellent results for treatment of typhoid fever in Indonesia as well as in other parts of South East Asia [18,19].…”

Section: Discussionmentioning

confidence: 99%

A Single Blind Comparative Randomized Non-Inferior Multicenter Study for Efficacy and Safety of Levofloxacin versus Ciprofloxacin in the Treatment of Uncomplicated Typhoid Fever

Nelwan¹,

Lie²,

Hadisaputro³

et al. 2013

AiM

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Ciprofloxacin is currently the drug of choice for typhoid fever, but Salmonella typhi resistance to ciprofloxacin is increasing, while levofloxacin has been shown to be very effective in a few open studies. This study aimed to compare the efficacy, and safety of levofloxacin and ciprofloxacin for typhoid fever. From 110 patients with confirmed typhoid fever, 54 patients received oral levofloxacin 500 mg once daily with one drop out, while 56 received ciprofloxacin 500 mg twice daily for 7 days with two drop outs. Defervescence of fever was achieved on an average of 3 days after initiating levofloxacin and 5 days after starting ciprofloxacin and one microbiologically non confirmed typhoid fever relapse occurred in the levofloxacin group while two relapses with positive Salmonella microorganism occurred in the ciprofloxacin group. No carrier of Salmonella typhi was found in both groups at day 30. Adverse reactions were more pronounced in the ciprofloxacin group compared to the levofloxacin group. In conclusion, oral levofloxacin 500 mg once daily for one week showed faster fever clearance compared to ciprofloxacin 500 mg twice daily in typhoid fever in Indonesia, and less adverse reactions occurred with levofloxacin compared to ciprofloxacin. This electronic document is a "live" template. The various components of your paper (title, text, heads, etc.) are already defined on the style sheet, as illustrated by the portions given in this document.

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Section: Discussionmentioning

confidence: 99%

A Single Blind Comparative Randomized Non-Inferior Multicenter Study for Efficacy and Safety of Levofloxacin versus Ciprofloxacin in the Treatment of Uncomplicated Typhoid Fever

Nelwan¹,

Lie²,

Hadisaputro³

et al. 2013

AiM

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“…Nelwan et al . reported clinical failure in four of 28 (14%) patients and relapse in one of 25 (4%) patients treated in three Indonesian cities in 1991 6 . No information was provided on either the nalidixic acid susceptibility or the ciprofloxacin MICs of their clinical isolates.…”

Section: Clinical Details Of Patients Treated With 3‐day Oral Ciproflmentioning

confidence: 99%