A comparative study of selected physical properties of aortic homografts and heterografts

Harris, Paul D.; Kowalik, A.T.W.; Beach, P. Maynard; Parodi, E; Castanay, R.; Bowman, Frederick O.; Malm, James R.

doi:10.1016/s0022-5223(19)42659-7

Cited by 9 publications

(1 citation statement)

References 8 publications

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“…The current trends in human cardiac valve surgery favor the heterografting of animal valves, which are more easily available and adaptable than those from human cadavers. In particular, porcine valves seem the most suitable and are often used (Harris et al 1969). The first heterotransplants of porcine valves made with fresh specimens were unsuccessful because the grafted valves, instead of making a template for regenerating host tissue, were rejected.…”

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confidence: 99%

Residual Heteroantigenicity of Glutaraldehyde‐Treated Porcine Cardiac Valves

1980

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Treatment of porcine valves in vitro with glutaraldehyde significantly decreases their hetero‐antigenicity, as judged by immune reaction in mice heterografted with glutaraldehyde‐treated valves or injected intraperitoneally with valvular homogenates. Conditioned porcine valves, grafted in a cutaneous pouch onto the backs of two different inbred strains (C57B1 and DBA) behave like inert material and show minimal cellular infiltration at histological examination. Little or no antibody response, demonstrable with the cytotoxity test is elicited by glutaraldehyde‐treated valvular tissue, either grafted or injected intraperitoneally as homogenate. These data supply a biological basis for the surgical practice of heterotransplants of glutaraldehyde‐treated valves as an alternative to the artificial prostheses.

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confidence: 99%

Residual Heteroantigenicity of Glutaraldehyde‐Treated Porcine Cardiac Valves

1980

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Biological and mechanical behavior of autologous pericardium used for tricuspid valvular replacement in dogs

Dureau

Kepenekian

Heynen

et al. 1981

J. Biomed. Mater. Res.

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The fate of autologous pericardium when used to replace a tricuspid valve leaflet has been investigated in dogs. Changes have been studied by means of macroscopic, mechanical, histological, scanning electron microscopy, and in vitro culture techniques. In each of nine experiments the valve failed and death occurred within the first 15 post-operative days. Retraction, thickening of the cusp, fibrinous deposition and/or tissue rupture were associated with a decrease of resistance to traction tests, decrease of elasticity and increase of viscosity of the implanted tissue. The early behavior of autologous pericardium was characterized by precocious inflammatory reaction on the valve leaflets, focal disruption of the collagenous structure of the leaflets, absence of fibroblastic cell infiltration as confirmed by in vitro culture of implanted pericardium and the lack of endothelial-like cell surface at the 10th-15th postoperative day.

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Mitral valve replacement by calf aortic heterograft and its clinical evaluation

Lorkiewicz

Anholcer

Gracz

et al. 1970

Langenbecks Arch Chiv

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The authors present the results of surgical management of patients with mitral valve lesions. In 21 subjects replacement of the mitral valve with calf aortic graft was performed. The heterograft prepared according to O'Brien's technique, and reinforced by a metal-terital ring, was inserted into the mitral ostium. The operative method is described and the enclosed tables show the clinical pre-and postoperative findings based on short term follow-up observations.The absence of any postoperative complications with the inserted heterografts, in contrast to multiple troubles with the use of artificial prostheses, is related to the qualities of biological tissue which seem superior to the plastic grafts. Further observation of the patients and a greater number of cases will enable us to draw more precise conclusions concerning the long term fate of heterografts.

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A comparative study of selected physical properties of aortic homografts and heterografts

Cited by 9 publications

References 8 publications

Residual Heteroantigenicity of Glutaraldehyde‐Treated Porcine Cardiac Valves

Residual Heteroantigenicity of Glutaraldehyde‐Treated Porcine Cardiac Valves

Biological and mechanical behavior of autologous pericardium used for tricuspid valvular replacement in dogs

Mitral valve replacement by calf aortic heterograft and its clinical evaluation

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