A comparative study of prevalence of mixed features in patients with unipolar and bipolar depression

Grover, Sandeep; Adarsh, Himani

doi:10.1016/j.ajp.2022.103439

Cited by 2 publications

(1 citation statement)

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“…Depression is a common mental disorder that severely affects quality of life and psychosocial functioning of patients (Affatato et al, 2021). During a depressive episode, people will experience different symptoms, such as empty, low self-worth, and a loss of pleasure, even thoughts about suicide (Grover and Adarsh, 2022;Ning et al, 2022). According to the reports of World Health Organization, depression affects about 3.8% of the population and causes huge economic burdens on individual, family and society.…”

Section: Introductionmentioning

confidence: 99%

Tryptophan metabolism as bridge between gut microbiota and brain in chronic social defeat stress-induced depression mice

Xie

Wu²,

Chen³

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundsGut microbiota plays a critical role in the onset and development of depression, but the underlying molecular mechanisms are unclear. This study was conducted to explore the relationships between gut microbiota and host’s metabolism in depression.MethodsChronic social defeat stress (CSDS) model of depression was established using C57BL/6 male mice. Fecal samples were collected from CSDS group and control group to measure gut microbiota and microbial metabolites. Meanwhile, tryptophan metabolism-related metabolites in hippocampus were also analyzed.ResultsCSDS successfully induced depressive-like behaviors in CSDS group. The 24 differential bacterial taxa between the two groups were identified, and 14 (60.87%) differential bacterial taxa belonged to phylum Firmicutes. Functional analysis showed that tryptophan metabolism was significantly affected in CSDS mice. Meanwhile, 120 differential microbial metabolites were identified, and two key tryptophan metabolism-related metabolites (tryptophan and 5-hydroxytryptophan (5-HTP)) were significantly decreased in feces of CSDS mice. The correlation analysis found the significant relationships between tryptophan and differential bacterial taxa under Firmicutes, especially genus Lactobacillus (r=0.801, p=0.0002). In addition, the significantly decreased 5-hydroxytryptamine (5-HT) in hippocampus of depressed mice was also observed.ConclusionsOur results showed that tryptophan metabolism might have an important role in the crosstalk between gut microbioa and brain in depression, and phylum Firmicutes, especially genus Lactobacillus, might be involved in the onset of depression through regulating tryptophan metabolism.

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Section: Introductionmentioning

confidence: 99%