A comparative study of prenatal development in Miniopterus schreibersii fuliginosus, Hipposideros armiger and H. pratti

Wang, Zhe; Han, Ning; Racey, Paul A.; Rü, B. Le; He, Guimei

doi:10.1186/1471-213x-10-10

Cited by 43 publications

(62 citation statements)

References 18 publications

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“…Bat forelimb digits condense at approximately stage 15 and elongate during subsequent stages [10] (electronic supplementary material, figure S1). To find genes likely to contribute to digit elongation, we applied mRNA-Seq to bat fore-and hindlimb digits at stages 15-17.…”

Section: Resultsmentioning

confidence: 99%

“…Bat and mouse embryonic stages are identified according to previous studies [10][11][12]. Because of differences in species, pregnancy duration and the heterochrony of forelimb and hindlimb, it is (a) figure S1); (iii) the number of phalanges (electronic supplementary material, figure S1); (iv) regression of interdigital tissues and (v) appearance of claw primordia or keratinized claws.…”

Section: (B) Identifying Embryonic Stagesmentioning

confidence: 99%

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Unique expression patterns of multiple key genes associated with the evolution of mammalian flight

et al. 2014

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Bats are the only mammals capable of true flight. Critical adaptations for flight include a pair of dramatically elongated hands with broad wing membranes. To study the molecular mechanisms of bat wing evolution, we perform genomewide mRNA sequencing and in situ hybridization for embryonic bat limbs. We identify seven key genes that display unique expression patterns in embryonic bat wings and feet, compared with mouse fore- and hindlimbs. The expression of all 5′HoxD genes ( Hoxd9–13 ) and Tbx3 , six known crucial transcription factors for limb and digit development, is extremely high and prolonged in the elongating wing area. The expression of Fam5c , a tumour suppressor, in bat limbs is bat-specific and significantly high in all short digit regions (the thumb and foot digits). These results suggest multiple genetic changes occurred independently during the evolution of bat wings to elongate the hand digits, promote membrane growth and keep other digits short. Our findings also indicate that the evolution of limb morphology depends on the complex integration of multiple gene regulatory networks and biological processes that control digit formation and identity, chondrogenesis, and interdigital regression or retention.

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Section: Resultsmentioning

confidence: 99%

Section: (B) Identifying Embryonic Stagesmentioning

confidence: 99%

Unique expression patterns of multiple key genes associated with the evolution of mammalian flight

et al. 2014

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“…Evidence from chick and mouse time-lapse imaging has revealed that NC cell chain migration occurs in the cranial, trunk and intestinal subregions of the embryo (Kulesa and Fraser 1998; Young, Anderson et al 2004; Kasemeier-Kulesa, Bradley et al 2006; Druckenbrod and Epstein 2007; Rupp and Kulesa 2007; Nishiyama, Uesaka et al 2012; Zhang, Kim et al 2012). NC cells in nearly every vertebrate model system (chick, mouse, zebrafish, axolotl, turtle, snake) have also been observed to travel in multicellular streams (Reyes et al, 2010; Kulesa and Fraser, 1998; Schilling and Kimmel, 1994; Golding et al, 2000; Epperlein et al, 2007; Gilbert et al, 2007). Interestingly, Xenopus NC cells travel as a cohesive sheet, resembling a spreading epithelial tissue layer (DeSimone et al, 2005; Carmona-Fontaine et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Follow-the-leader cell migration requires biased cell–cell contact and local microenvironmental signals

et al. 2013

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Directed cell migration often involves at least two types of cell motility that include multicellular streaming and chain migration. However, what is unclear is how cell contact dynamics and the distinct microenvironments through which cells travel influence the selection of one migratory mode or the other. The embryonic and highly invasive neural crest (NC) are an excellent model system to study this question since NC cells have been observed in vivo to display both of these types of cell motility. Here, we present data from tissue transplantation experiments in chick and in silico modeling that test our hypothesis that cell contact dynamics with each other and the microenvironment promote and sustain either multicellular stream or chain migration. We show that when premigratory cranial NC cells (at the pre-otic level) are transplanted into a more caudal region in the head (at the post-otic level), cells alter their characteristic stream behavior and migrate in chains. Similarly, post-otic NC cells migrate in streams after transplantation into the pre-otic hindbrain, suggesting that local microenvironmental signals dictate the mode of NC cell migration. Simulations of an agent based model (ABM) that integrates the NC cell behavioral data predict that chain migration critically depends on the interplay of biased cell-cell contact and local microenvironment signals. Together, this integrated modeling and experimental approach suggests new experiments and offers a powerful tool to examine mechanisms that underlie complex cell migration patterns.

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“…This up and coming method is made possible by the growing numbers of high resolution mass analyzers, such as orbitrap, quadrupole time-of-flight, and Fourier transform-ion cyclotron resonance, as well as the sophisticated supporting software. Recent studies have demonstrated the utility of spectral counting for measuring endogenous peptides by exploring day–night changes in peptide expression profiles for the mammalian suprachiasmatic nucleus [18], and by examining peptides involved in the embryogenesis of Japanese quails [19] and endogenous peptides in the nucleus accumbens of morphine-dependent rats [20]. Spectral counting and peak intensity comparisons showcase the power of MS as an exploration technique because it combines structural and qualitative characterization in one experiment, without additional sample modifications.…”

Section: Current Approaches For Quantitation With Mass Spectrometrymentioning

confidence: 99%

Quantitation of endogenous peptides using mass spectrometry based methods

Romanova

Dowd

Sweedler

2013

Current Opinion in Chemical Biology

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The mass spectrometry-based “omics” sub-discipline that focuses on comprehensive, often exploratory, analyses of endogenous peptides involved in cell-to-cell communication is oftentimes referred to as peptidomics. While the progress in bioanalytical technology development for peptide discovery has been tremendous, perhaps the largest advances have involved robust quantitative mass spectrometric approaches and data mining algorithms. These efforts have accelerated the discovery and validation of biomarkers, functionally important posttranslational modifications, and unexpected molecular interactions, information that aids drug development. In this article we outline the current approaches used in quantitative peptidomics and the technical challenges that stimulate new advances in the field, while also reviewing the newest literature on functional characterizations of endogenous peptides using quantitative mass spectrometry.

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A comparative study of prenatal development in Miniopterus schreibersii fuliginosus, Hipposideros armiger and H. pratti

Cited by 43 publications

References 18 publications

Unique expression patterns of multiple key genes associated with the evolution of mammalian flight

Unique expression patterns of multiple key genes associated with the evolution of mammalian flight

Follow-the-leader cell migration requires biased cell–cell contact and local microenvironmental signals

Quantitation of endogenous peptides using mass spectrometry based methods

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