A Comparative Study of Platelet-rich Fibrin (PRF) and Titanium-prepared Platelet-rich Fibrin (T-PRF) in Management of Endo-perio Lesions

Razi, Mohammed Ahsan; Mahajan, Ankit; Qamar, Seema; Mehra, Salil K.; Roy, Tulika Rani; Kumari, Puja

doi:10.5005/jp-journals-10024-2865

Cited by 7 publications

(9 citation statements)

References 21 publications

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“…It is important to note that endodontic and periodontal treatments were implemented simultaneously in most trials [ 6 , 7 , 8 , 9 , 10 ]. Razi et al [ 1 ] performed the endodontic treatment first. Similarly, Gupta et al trial completed endodontic treatment first.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies were non-randomized clinical trials [ 1 , 9 ], and five were RCTs [ 3 , 6 , 7 , 8 , 10 ]. All studies had a follow-up period of between 6 and 24 months.…”

Section: Resultsmentioning

confidence: 99%

“…Because a new classification of EPL has been recently introduced [ 2 ], the diagnoses presented in the included articles are reflected as follows: endo-periodontal lesion in periodontitis patients in three trials [ 7 , 9 , 10 ] and endo-periodontal lesion in non-periodontitis patients in the remaining four experiments [ 1 , 3 , 6 , 8 ].…”

Section: Resultsmentioning

confidence: 99%

“…The periodontium and the dental pulp communicate through anatomical (exposed dentin, accessory canals, and the apical foramen) or pathological (root fractures) forms. These communications allow for the appearance of lesions that concurrently affect the periodontal and pulpal tissues, called endodontic-periodontal (endo-perio) lesions (EPL) [ 1 ]. These lesions can compromise patients with or without periodontitis according to a recent classification, which also indicates that the primary origin (endodontic or periodontal) is not crucial for treatment [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Efficacy of Treatment of Endodontic-Periodontal Lesions: A Systematic Scoping Review of Experimental Studies

Medina

Vivares-Builes

2022

IJERPH

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Background: In this review, we evaluated the clinical efficacy of interventions used for the treatment of endo-perio lesions (EPL). Methods: A systematic scoping review of clinical trials was developed. Results: Seven clinical trials were studied. In at least one study group of six of the seven evaluated trials, endodontic and periodontal treatments were performed simultaneously. All trials showed improvement in probing depth in the studied groups; nevertheless, the experimental groups of five studies demonstrated a statistically significant reduction in this parameter. An increase in clinical attachment level was also reported (p < 0.05). Most trials reported an increase in the filling of the bone defect following therapy (p < 0.05). Mechanical periodontal therapy implemented simultaneously with endodontic therapy demonstrated efficacy in the treatment of concurrent EPL without communication. Endodontic treatment and immediate periodontal surgery did not affect the result of the management of combined EPL with apical communication. The use of diode laser, the management of platelet-rich fibrin (PRF) and titanium-prepared PRF, and the implementation of bone grafts plus endodontic treatment with mineral-trioxide or gutta-percha seems to be an adequate strategy in patients with EPL. Conclusions: The treatment of EPL using simultaneous endodontic and periodontal therapies seems to be an acceptable treatment alternative.

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Section: Resultsmentioning

confidence: 99%

“…Two studies were non-randomized clinical trials [ 1 , 9 ], and five were RCTs [ 3 , 6 , 7 , 8 , 10 ]. All studies had a follow-up period of between 6 and 24 months.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical Efficacy of Treatment of Endodontic-Periodontal Lesions: A Systematic Scoping Review of Experimental Studies

Medina

Vivares-Builes

2022

IJERPH

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“…When combined with open flap debridement (OFD), the use of T-PRF membranes leads to a significant release of the greater number of growth factor concentrations and a lower number of 'RANKL/OPG ratio' in GCF [31]. T-PRF helps gain attachment level and lower pocket depth while treating endo-perio lesions [32].…”

Section: Clinical Applicationsmentioning

confidence: 99%

Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Shirbhate¹,

Bajaj²

2022

Cureus

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Platelets are important for hemostasis and the healing of wounds. In clinical settings, healing cytokines including insulin-like growth factors (IGF), platelet-derived growth factors (PDGF), and transforming growth factors (TGF) are commonly implemented. The regenerative approach in dentistry frequently employs platelet concentrates (PCs) that are "autologous in origin" and have a high concentration of platelets, growth factors, and leukocytes. First-generation PCs is made of platelet-rich plasma (PRP), while secondgeneration PC is made of platelet-rich fibrin (PRF). Both have limitations, so modification protocols and development in PRP and PRF derivatives are required for advancement mechanisms, strength, biodegradability, retention ability in the field of regenerative dentistry, and so on. As third-generation PC, newer genera kinds of PRF, such as advanced-PRF (A-PRF), advanced-PRF+ (A-PRF+), injectable-PRF (i-PRF), and titanium-PRF (T-PRF), were introduced. A-PRF matrices in their solid form were introduced using the low-speed centrifugation concept (LSCC). The applied relative centrifugal force (RCF) for A-PRF is reduced to 208 g as a result of this improved preparation process. A-PRF features a greater number of neutrophil granules in the distal region, especially at the red blood cells-buffer coat (RBC-BC) interface, and the A-PRF clot has a more porosity-like structure with a bigger interfibrous space than PRF. Since the PRF is in a gel form and is difficult to inject, i-PRF was formulated to address this problem. Compared to the other two protocols, the i-PRF protocol requires far less time, and this is the advantage of this PC. This is because i-PRF just needs the blood components to be separated, which happens within the first two to four minutes. Compared to normal L-PRF, T-PRF creates fibrin that is thicker and more densely woven. Titanium has a higher hemocompatibility than glass, which could lead to greater polymerized fibrin formation. In periodontal regenerative operations, oral surgery, and implant dentistry, PRF and its newer advanced modifications have demonstrated promising results and desirable results in both soft and hard tissue regenerative techniques.

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Management of teeth with endodontic-periodontal lesions

Nasiri,

Wrbas

2024

Journal of Dental Sciences

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A Comparative Study of Platelet-rich Fibrin (PRF) and Titanium-prepared Platelet-rich Fibrin (T-PRF) in Management of Endo-perio Lesions

Cited by 7 publications

References 21 publications

Clinical Efficacy of Treatment of Endodontic-Periodontal Lesions: A Systematic Scoping Review of Experimental Studies

Clinical Efficacy of Treatment of Endodontic-Periodontal Lesions: A Systematic Scoping Review of Experimental Studies

Third-Generation Platelet Concentrates in Periodontal Regeneration: Gaining Ground in the Field of Regeneration

Management of teeth with endodontic-periodontal lesions

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