A Comparative Study of Ondansetron Versus Granisetron in the Prevention of Postoperative Nausea and Vomiting (Ponv) in Day Care Gynaecological Laparoscopic Surgeries

Abstract

BACKGROUND The antiemetic action of 5-hydroxytryptamine receptor antagonists (5HT3 receptor blockers) has been well established. The present study compared the efficacy of the 5HT3 receptor blockers Ondansetron and Granisetron, in reducing the Post-Operative Nausea and Vomiting in day care gynaecological laparoscopic surgeries. Aims and Objectives-To compare the efficacy of intravenous Ondansetron versus Granisetron in the prevention of post-operative nausea and vomiting in patients undergoing day care gynaecological laparoscopic surgeries. MATERIALS AND METHODS 60 patients of ASA Grade 1 and II, between 18-55 years of age undergoing day care gynaecological surgeries were included in the present study. They were allocated into 2 groups of 30 each. The sample size was taken for convenience during the study. Group A received 4 mg (2 mL) of Ondansetron intravenously, Group B received 2 mg (2 mL) of Granisetron intravenously prior to induction of general anaesthesia. Each of these groups were assessed for the incidence of post-operative nausea, pain, emesis and adverse effects. RESULTS Incidence of nausea in the first 2 hrs. was the same in both the groups 16.6% (n= 5). The overall incidence of nausea in 0 to 24 hrs. in Group A and Group B was 23.3% (n= 7) and 20% (n= 6) respectively. The overall incidence of emesis in 0-24 hrs. after the surgery was found to be similar 6.6% (n= 2) in both the groups. No adverse effects were observed in both the groups. There was no statistically significant difference between Ondansetron and Granisetron with regards to their efficacy in minimising postoperative nausea and vomiting (p value > 0.05). CONCLUSION In conclusion, intravenous administration of 4 mg Ondansetron or 2 mg Granisetron prior to induction of general anaesthesia is equally effective in preventing the post-operative nausea and vomiting in day care gynaecological laparoscopic surgeries.