A comparative study of manganese meso-sulfonatophenyl porphyrins: Contrast-enhancing agents for tumors

Fiel, Robert J.; Musser, David A.; Mark, E.H.; Mazurchuk, Richard; Alletto, James J.

doi:10.1016/0730-725x(90)90097-l

Cited by 51 publications

(25 citation statements)

References 11 publications

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“…Sulphonated manganese-and iron-porphyrins have been developed in our laboratory for mimicking ligninase (Labat & Meunier, 1989) or chloroperoxidase (Labat & Meunier, 1990), and as biomimetic catalysts for the oxidation of pollutants or drugs (Bernadou et al, 1991;Vidal et al, 1993;Gaggero et al, 1994). The manganese complex of meso-tetrasulphonatophenylporphyrin (l-Mn; Table 1) has also been studied by several groups as a contrastenhancing agent for tumour imaging by nuclear magnetic resonance (NMR) imaging (Megnin et al, 1987;Fiel et al, 1990). No toxicity of l-Mn was observed to the human breast cancer cell line MCF-7 at 0.1 mg mL-l (Megnin et al,1987).…”

Section: Introductionmentioning

confidence: 99%

Anti-HIV Activities of Anionic Metalloporphyrins and Related Compounds

Song

Witvrouw

Schols

et al. 1997

Antivir Chem Chemother

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SummaryVarious water-soluble polysulphonated and polycarboxylated porphyrins and some of their metallated derivatives have been prepared and their antiviral properties against human immunodeficiency virus (HIV-1, HIV-2), simian immunodeficiency virus and other viruses are reported. Besides these polyanionic compounds, two new series of porphyrins were included and studied from the perspective of bio-availability modulation: (i) acetylsulphonamido derivatives endowed with weak acidity properties (deprotonation gives the corresponding anionic derivatives in a pH range 4.5-8.5) and (ii) compounds with the anionic charge transiently masked by esterification (acetoxymethyl-and pivaloyloxymethylesters). Among the more active compounds in inhibiting HIV-induced cytopathic effects, the sulphonated and carboxylated porphyrin complexes were found to interact directly with the HIV protein gp 120 and not with the CD4 cellular receptor.

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Section: Introductionmentioning

confidence: 99%

Anti-HIV Activities of Anionic Metalloporphyrins and Related Compounds

Song

Witvrouw

Schols

et al. 1997

Antivir Chem Chemother

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“…The rationales governing porphyrin-mediated cancer photodynamic therapy are based on ''tumor-localizing'' and photosensitizing properties of the agents. By analogy, the tumor ''preferential uptake'' of porphyrins has also been exploited for developing paramagnetic metalloporphyrins as ''tumor-seeking'' MRI contrast agents (Chen et al 1984;Ogan et al 1987;Furmanski and Longley 1988;Bockhorst et al 1990;Fiel et al 1990;Van Zijl et al 1990;Nelson and Schmiedl 1991;Ebert et al 1992;Place et al 1992;Hindre et al 1993;Young et al 1994;Saini et al 1995).…”

Section: 4mentioning

confidence: 97%

MR Contrast Agents for Cardiac Imaging

2011

Clinical Cardiac MRI

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“…Mn-porphyrins show high stability compared to other metalloporphyrins, usually having much higher longitudinal relaxivities [20]. In addition, Mn-porphyrins are intended to be used as targeted MRI agents because of their tumorous ''preferential uptake'' property [20,21]. Compared with SPIO NPs, small molecule paramagnetic metal complexes have more advantages due to high contrast ability and easy urinary excretion [1].…”

Section: Introductionmentioning

confidence: 98%