Abstract:Cholera toxin, encoded by the ctx gene, is a key virulence factor in toxigenic Vibrio cholerae (ctx+) strains. However, some non-toxigenic V. cholerae (ctx-) strains are also pathogenic to humans and the mechanism involved in low-pH tolerance and pathogenicity in these strains remains unclear. To address this, we profiled the growth and chitinase activity in different pH of two clinical isolates of V. cholerae: VC20, a ctx+ strain, and WO5, a ctx- strain. We also compared the expression level of key genes invo… Show more
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