A Comparative Study of Loratadine Syrup and Cyproheptadine HCL Solution for Treating Perennial Allergic Rhinitis in Taiwanese Children Aged 2–12 Years

Abstract

We assessed the efficacy of loratadine syrup compared with cyproheptadine HCl solution for treating children aged from 2 to 12 years with perennial allergic rhinitis (PAR) in Taiwan. Sixty children with mite-induced PAR were enrolled and randomly placed into two treatment groups: loratadine syrup or cyproheptadine HCl solution. Treatment efficacy and symptom changes from baseline to post-treatment were evaluated by total symptom scores and visual analogue scales (VAS) during a 2-week period. There were no differences in age, gender, height, or weight between the two groups. After 2 weeks of treatment, there was a significantly greater reduction in symptom scores in the loratadine group than in the cyproheptadine group ( p<0.001). Clinical and subjective VAS showed significant differences in percentage changes from baseline between the loratadine and cyproheptadine groups at all time points (all p<0.001, in favor of loratadine). Clinical VAS change at week 1: 95.1 vs 11.3; subjective VAS change at week 1: 88.6 vs 13.6; clinical VAS change at week 2: 125.5 vs 18.3; subjective VAS change at week 2: 101.4 vs 7.1. Thus, loratadine was superior to cyproheptadine for alleviating both nasal and non-nasal symptoms of perennial allergic rhinitis in Taiwanese children aged 2–12 years.

Synthesis, Characterization and Toxicity Evaluation of Cu(II), Mn(II), Co(II), Ni(II), Pd(II) Complexes with Ligand Derived from Hydrazinecarbothioamide

“…Thermal analyses data reveal that compounds 1-6 and 8 are hydrated, having a weight loss between 100 and 211 o C which corresponds to one molecule (1,3,4,6,8) or two molecules (2, 5) of water respectively directly bonded to the metal center. The second weight loss steps correspond to the release of small coordinated anions: OAc -, Cl -, ClO 4 -.…”

“…The tricyclic framework of 5H-dibenzo[a,d] [7]annulene constitutes an integral part of the structure of molecules that are known to be effective for the treatment of depressive disorders [1,2]. Analogs of 5H-dibenzo[a,d] [7]annulene, such as Protriptyline and Demexiptyline, are well known tricyclic antidepressants [3]. Dibenzo [a,d] [7]annulene derivatives exhibit antidiabetic, antiparasitic, metalloprotease inhibitors, antihypertensive, orexygenic and antimicrobial activity [4,5].…”

Are antihistamines effective in children? A review of the evidence

“…Small prospective studies evaluated cyproheptadine in children with allergic conditions, including primary acquired cold urticaria26 and mite-induced allergic rhinitis 27. In each of these trials, the active comparator (ketotifen and loratadine, respectively) showed similar or better results when compared with cyproheptadine (table 3).…”

Histamine, histamine receptors, and anti-histamines in the context of allergic responses

“…Up to 30-fold overdoses of loratadine have not been causally associated with serious adverse events or fatality. A study by Wu et al (2012) comparing the efficacy of treatment for persistent allergic rhinitis (PAR) in children 2-12 years old of loratadine syrup formulation and cyproheptadine solution described a significantly reduced total symptom score with an improvement in side effects involving the central nervous system in the loratadine group. In the Preventia I study, well tolerated long term safety effects were described in the 12-30 months of age group during Phase I studies.…”