A Comparative study of IV Labetalol and IV Hydralazine on mean arterial blood pressure changes in pregnant women with hypertensive emergency

Abstract

Abstract:The study was undertaken to compare lowering of blood pressure in pregnant women with hypertensive emergency by IV Labetalol and IV Hydralazine and to find out which drug produces better effect. This prospective type of interventional study was conducted in SMS Medical College, Jaipur among 226 women admitted with SBP ≥ 160 or DBP ≥ 110 mmHg or both. Women divided in 2 groups (113 each) devided randomly: Labetalol (Group-A), Hydralazine (Group-B).We measured the difference between pretreatment and after treatment mean arterial blood pressure. Pretreatment mean arterial blood pressure was 127.40±40 and 126.61±6.475 mmHg in labetalol and Hydralazine group respectively. After treatment mean arterial blood pressure was 112.25±5.821 and 109.27±14.30 mmHg in labetalol and Hydralazine group respectively. Mean arterial blood pressure change was 15.14 ± 8.02 mmHg in labetalol group and 17.34 ± 13.42 mmHg in hydralazine group. (p=0.136, Not significant). Labetalol and Hydralazine both drugs are first line drugs in severe hypertension in pregnancy as in our study both drugs control blood pressure in similar way.

Comparison of Hydralazine and Labetalol to lower severe hypertension in pregnancy

“…in their comparative study on Labetalol and Hydrallazine found both drugs as effective and quick acting antihypertensive agents in severe pre eclampsia. 15 Numba in his study demonstrated Labetalol and Hydralazine effective and rapid anti-hypertensive agent in hypertension crises. 9 The time taken to lower blood pressure and number of doses of Hydralazine and Labetalol were similar in Numba study.…”

Comparison of Efficacy and Safety of Intravenous Labetalol Versus Hydralazine for Management of Severe Hypertension in Pregnancy

“…A comparative study of IV Labetalol and IV Hydralazine on mean arterial blood pressure changes in pregnant women with hypertensive emergency by Swati et al [9] showed no significant difference between the changes in the mean arterial blood pressure after giving drugs; concluding that both the drugs were equally effective in management of severe hypertension in pregnancy.…”

Drugs for treating severe hypertension in pregnancy: a network meta‐analysis and trial sequential analysis of randomized clinical trials

“…A total of 320 articles were retrieved, of which 51 were included in the systematic review and 46 in the meta‐analysis. The PRISMA flow chart is depicted in Figure .…”