A Comparative Study of Intravenous Nalbuphine HCl and Tramadol HCl for PostOperative Pain Relief Following Orthopaedic Surgeries

Solanki, Rekha; Gosai, Nita D; Joshi, G. P.; Patel, Bipin; Modi, HN; Jain, Ragi

doi:10.21276/apjhs.2015.2.1.26

Cited by 11 publications

(13 citation statements)

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“…Delayed awakening or increase sedation score was found more associated with Nalbuphine than Tramadol and Fentanyl in our study but it was not significant. This is supported by the study done by Solanki et al 12 who also found more sedation scores in patients who received Nalbuphine as compared to Tramadol. Though, none of their patients had significant sedation as in our study.…”

Section: Ivdisscussionsupporting

confidence: 66%

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Randomized Comparison Of Tramadol, Nalbuphine And Fentanyl Used As Premedication In Attenuation Of Hemodynamic Response To Laryngoscopy And Postoperative Pain In Laparoscopic Cholecystecyomy

Sharma¹,

Audichya²,

Goyal³

et al. 2016

IJMSCI

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Section: Ivdisscussionsupporting

confidence: 66%

“…Tramadol is atypical weak synthetic opioid. It has low µ receptor affinity but also exerts GABAnergic, Noradrenergic and Serotonergic effects 12 . Potency is 10% that of Morphine.…”

Section: Ivdisscussionmentioning

confidence: 99%

Randomized Comparison Of Tramadol, Nalbuphine And Fentanyl Used As Premedication In Attenuation Of Hemodynamic Response To Laryngoscopy And Postoperative Pain In Laparoscopic Cholecystecyomy

Sharma¹,

Audichya²,

Goyal³

et al. 2016

IJMSCI

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“…Nalbuphine has been found to provide better pain relief and hemodynamic stability compared to tramadol in patients undergoing orthopedic surgeries. [10] Nalbuphine was found to have a significant reduction in pain for the first two hours compared to fentanyl in patients who underwent short elective surgeries. When compared to fentanyl, nalbuphine was found to have a longer duration of postoperative analgesia with minimal side-effects.…”

Section: Discussionmentioning

confidence: 95%

Intravenous Nalbuphine as a Sole Analgesic in Head and Neck Oncosurgeries.

Tandale

Kulkarni

Patil

et al. 2019

AAN

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Background: Aim: To assess the analgesic and hemodynamic stability of nalbuphine as a sole analgesic in head and neck oncosurgeris. Subjects and Methods: A prospective observational study was conducted to assess the effect of intravenous nalbuphine in adult patients undergoing head and neck oncology surgeries. A total of 101 ASA I to III patients were included in the study. Patients aged 18 to 80 years scheduled for head and neck oncology surgeries were included. Results: The average duration of analgesia was 223.63 minutes. The mean pulse rate preoperatively was 84.42±13.38 per minute. The duration of analgesia (360 minutes) was highest in 38 patients while only two patients had an analgesic effect for 120 minutes. Only one patient reported to have respiratory depression while one had nausea. Post-operative ventilator was required for one patient. Conclusion: Nalbuphine can be considered as an ideal analgesic considering its efficiency in maintaining hemodynamic stability and effect of analgesia for long-duration surgeries. The side-effect profile of nalbuphine was favorable making it an ideal component for balanced anesthesia.

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“…It has antagonistic activity at Mu receptors and an agonist at the Kappa and Delta receptors [10]. It is speculated that Nalbuphine is capable of altering the perception of pain as well as emotional response to it [11]. The use of Nalbuphine in veterinary practice has not been extensively reported, though the purpose of this study is to investigate Nalbuphine and compare it with Pentazocine for efficacy and adverse effects.…”

Section: Introductionmentioning

confidence: 99%

“…Both Nalbuphine and Pentazocine have been a staple part of postoperative analgesic management in human medicine for last few decades. Yet, its application in veterinary practices has faced skepticism and unilateral incoherence of research [11]. Consequently, our study focused on similarly placed analgesics on opioid scale suitable for instances where more potent opioids were either unavailable due to legal constraints or their cost was a limiting factor.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Nalbuphine and Pentazocine in Controlling Postoperative Pain in Dogs

Rabbani¹,

Hayat²,

Gardezi³

et al. 2018

Matrix sci. medica

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Surgical success in most cases is governed by the quality of post-operative pain management. In Pakistan, most veterinary surgeons face a dire predicament as they fail astutely in this regard. Owing to the controlled dispensing of potent narcotics and their potential misuse, an imperative need for effective post-operative analgesic management of pain exists in dogs. 32 dogs were randomly divided into two groups. Group A was injected Nalbuphine @ 0.5 mg/kg post-operatively while Group B was injected Pentazocine @ 3mg/kg. Subjective and objective analysis of pain was conducted by unbiased observers. Vital signs (Temperature, pulse, respiration) were analyzed along with supplementation of hepatic and renal function tests. Objective and subjective analysis of both groups yielded results in the favor of pentazocine. In group A, temperature, pulse and respiration averaged 101.86±0.58 o F, 83.46±2.75 per minute and 19.26±2.14 per minute respectively. Group 2 demonstrated temperature, pulse and respiration averages of 102.31±0.40 o F, 83.41±2.74 per minute and 19.54±2.14 per minute respectively. Values of hepatic and renal function were also observed to be significantly higher in Nalbuphine treated group. All the results indicate that pentazocine is not only a significantly better analgesic but also has lower hepatotoxic and renal toxic effects.

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A Comparative Study of Intravenous Nalbuphine HCl and Tramadol HCl for PostOperative Pain Relief Following Orthopaedic Surgeries

Cited by 11 publications

References 0 publications

Randomized Comparison Of Tramadol, Nalbuphine And Fentanyl Used As Premedication In Attenuation Of Hemodynamic Response To Laryngoscopy And Postoperative Pain In Laparoscopic Cholecystecyomy

Randomized Comparison Of Tramadol, Nalbuphine And Fentanyl Used As Premedication In Attenuation Of Hemodynamic Response To Laryngoscopy And Postoperative Pain In Laparoscopic Cholecystecyomy

Intravenous Nalbuphine as a Sole Analgesic in Head and Neck Oncosurgeries.

A Comparison of Nalbuphine and Pentazocine in Controlling Postoperative Pain in Dogs

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