1994
DOI: 10.1111/j.1398-9995.1994.tb02660.x
|View full text |Cite
|
Sign up to set email alerts
|

A comparative study of IgG subclass antibodies in patients allergic to wasp or bee venom

Abstract: IgG1 and IgG4 antivenom antibody responses were compared in groups of patients who had experienced systemic reactions to wasp (Vespula spp.) or bee stings. Pretreatment serum IgG4 antibody levels were low in both groups, but IgG1 antibodies were significantly raised in bee-allergic patients (P < 0.002), probably reflecting their greater exposure to stings than wasp-reactive patients. No direct or indirect relationships were found, in untreated bee or wasp patients, between IgG1, IgG4, or IgE antibody levels an… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

2
16
0
1

Year Published

1996
1996
2017
2017

Publication Types

Select...
7
2
1

Relationship

1
9

Authors

Journals

citations
Cited by 38 publications
(19 citation statements)
references
References 29 publications
(12 reference statements)
2
16
0
1
Order By: Relevance
“…The IgG3 and IgG4 antibody levels were low at the start of VIT, but later the venom-specific IgG4 increased dramatically, which is typical of successful VIT treatments [10,31] . No major changes were generally ob-served for the other IgG subclasses, but an increase in specific IgG1 was observed in some patients, as reported by others [32] . Only minor changes in specific IgE were seen in some of the patients.…”
Section: Discussionsupporting
confidence: 61%
“…The IgG3 and IgG4 antibody levels were low at the start of VIT, but later the venom-specific IgG4 increased dramatically, which is typical of successful VIT treatments [10,31] . No major changes were generally ob-served for the other IgG subclasses, but an increase in specific IgG1 was observed in some patients, as reported by others [32] . Only minor changes in specific IgE were seen in some of the patients.…”
Section: Discussionsupporting
confidence: 61%
“…The level of IgE to venom does not reliably reflect the severity of the last reaction [3,23,27,28] and this is confirmed in our study of double-positive patients, where the same proportion (50%) of vespula-allergic patients with specific IgE of class 2 and below, or class 3 and above, were candidates for desensitization therapy. Whether the level of venom-specific IgE or IgG is a predictor of subsequent reactivity is still controversial [1,3,[29][30][31][32][33][34], but there is little evidence in this cohort of frequent clinical sensitivity to both venoms in double-positive patients.…”
Section: Discussionmentioning
confidence: 99%
“…The precise role of the antibodies is controversial; they are proposed to bind to the allergen and prevent its causing mast cell degranulation via IgE binding. Levels of allergen-specific IgG (total IgG or IgG4) do not predict or correlate with a clinical response to immunotherapy [74][75][76][77].…”
Section: Example 7 Carboplatin Desensitization [96]mentioning
confidence: 99%