A comparative study of histone acetylation in neuronal and glial nuclei enriched rat brain fractions

Hi, Sarkander; Fleischer-Lambropoulos, H; Wp, Brade

doi:10.1016/0014-5793(75)80633-8

Cited by 23 publications

(5 citation statements)

References 16 publications

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“…The role of HDACi in the treatment of multiple sclerosis (MS) was identified by early studies indicating that neuronal traits may be modulated by histone acetylation of neuronal genes [77]. The specific repressor protein, repressor element 1 silencing transcription factor (REST), is important since dysregulated REST contributes to neuronal loss [78].…”

Section: Histone Deacetylase Inhibitors and Immune-mediated Diseasementioning

confidence: 99%

Regulation of Immune Responses by Histone Deacetylase Inhibitors

Licciardi

Karagiannis

2012

ISRN Hematology

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Both genetic and epigenetic factors are important regulators of the immune system. There is an increasing body of evidence attesting to epigenetic modifications that influence the development of distinct innate and adaptive immune response cells. Chromatin remodelling via acetylation, methylation, phosphorylation, and ubiquitination of histone proteins as well as DNA, methylation is epigenetic mechanisms by which immune gene expression can be controlled. In this paper, we will discuss the role of epigenetics in the regulation of host immunity, with particular emphasis on histone deacetylase inhibitors. In particular, the role of HDAC inhibitors as a new class of immunomodulatory therapeutics will also be reviewed.

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Section: Histone Deacetylase Inhibitors and Immune-mediated Diseasementioning

confidence: 99%

Regulation of Immune Responses by Histone Deacetylase Inhibitors

Licciardi

Karagiannis

2012

ISRN Hematology

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“…Indeed, acetylation of histones in brain neuronal fractions was observed as early as 1975 (Sarkander et al 1975), and it has now been demonstrated that HDACs play important roles in both neuron differentiation (Liu et al 2008), expression of neuron-specific genes (Lakowski et al 2006) and the regulation of diverse cues such as maternal grooming (Weaver et al 2004) and addiction (Renthal et al 2007). Class II and class III histone deacetylases play pivotal roles in both neuronal proliferation and differentiation (Horio et al 2003; Kyrylenko et al 2003; Ajamian et al 2003; Hoshino et al 2003).…”

Section: Consequences Of Mutant Htt and Aberrant Ptms In Hdmentioning

confidence: 99%

Targeting Huntington’s disease through histone deacetylases

Gray

2011

Clin Epigenet

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Huntington’s disease (HD) is a debilitating neurodegenerative condition with significant burdens on both patient and healthcare costs. Despite extensive research, treatment options for patients with this condition remain limited. Aberrant post-translational modification (PTM) of proteins is emerging as an important element in the pathogenesis of HD. These PTMs include acetylation, phosphorylation, methylation, sumoylation and ubiquitination. Several families of proteins are involved with the regulation of these PTMs. In this review, I discuss the current evidence linking aberrant PTMs and/or aberrant regulation of the cellular machinery regulating these PTMs to HD pathogenesis. Finally, I discuss the evidence suggesting that pharmacologically targeting one of these protein families the histone deacetylases may be of potential therapeutic benefit in the treatment of HD.

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“…A study carried out in 1975 examined the acetylation status of histones in neuronal fractions [206]. Most recently it has now been demonstrated that HDACs play important roles in both neuron differentiation [207], expression of neuron‐specific genes [208], and indeed regulate diverse cues such as maternal grooming [209], and addiction [210].…”

Section: The Potential Role Of Histone Deacetylase Inhibitors In the mentioning

confidence: 99%

Targeting histone deacetylases for the treatment of disease

Lawless

Norris

O’Byrne

et al. 2009

J Cellular Molecular Medi

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The ‘histone code’ is a well-established hypothesis describing the idea that specific patterns of post-translational modifications to histones act like a molecular ‘code’ recognized and used by non-histone proteins to regulate specific chromatin functions. One modification, which has received significant attention, is that of histone acetylation. The enzymes that regulate this modification are described as lysine acetyltransferases or KATs, and histone deacetylases or HDACs. Due to their conserved catalytic domain HDACs have been actively targeted as a therapeutic target. The pro-inflammatory environment is increasingly being recognized as a critical element for both degenerative diseases and cancer. The present review will discuss the current knowledge surrounding the clinical potential and current development of histone deacetylases for the treatment of diseases for which a pro-inflammatory environment plays important roles, and the molecular mechanisms by which such inhibitors may play important functions in modulating the pro-inflammatory environment.

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A comparative study of histone acetylation in neuronal and glial nuclei enriched rat brain fractions

Cited by 23 publications

References 16 publications

Regulation of Immune Responses by Histone Deacetylase Inhibitors

Regulation of Immune Responses by Histone Deacetylase Inhibitors

Targeting Huntington’s disease through histone deacetylases

Targeting histone deacetylases for the treatment of disease

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