A Comparative Study of GABA, Glutamate Contents, Acetylcholinesterase Inhibition and Antiradical Activity of the Methanolic Extracts from 10 Edible Plants

Abstract

In order to investigate the efficacies for cognitive function of edible plants, we measured the inhibitory effects of acetylcholinesterase(AChE) activity, radical scavenging activities, and the contents of GABA and glutamate in the plant extracts. Among the plant extracts, Schizandra chinensis contained the highest GABA 14.8 mg/g and the extracts of Cnidium officinale and Polygonum multiflorum also had a relatively high GABA. On the other hand, plant extracts except, Acorus gramineus, showed similar glutamate contents. S. chinensis, Hovenia dulcis, Thuja orientalis, and Eleutherococcus senticosus exhibited high inhibition against AChE activities at about 18-33% at 1 mg/mL. In addition, strong radical scavenging activities were also detected in those extracts which showed high AChE inhibition. Taken together, H. dulcis, T. orientalis, E. senticosus, and S. chinensis could be effective resources for enhancing cognitive function. Further, it was suggested that the AChE inhibitory activities of plant extracts might be related to antioxidative activity.

Wasabia koreana Nakai: A Preliminary Study on Nutrients and Chemical Compounds That May Impact Sensory Properties

“…It also contributes to the dispersion, transfer, differentiation, and extension of neurite and synapse formation, regulates the growth of embryonic stem cells and neural stem cells, and affects the growth of neurons through cerebral nerve stimulators. GABA contents in all three wasabi parts were quite high, indicating the potential use of wasabi as a GABA source [ 24 , 25 ]. In addition, the leaf and petiole had relatively high proportions of alanine (12.49 ± 0.43% and 19.55 ± 0.61%) and valine (8.81 ± 0.17% and 9.25 ± 0.31%).…”

Assessment of Physicochemical Quality, Antioxidant Content and Activity, and Inhibition of Cholinesterase between Unripe and Ripe Blueberry Fruit

“…The antioxidative effects of polyphenols in plants are expected to have a potential effect on the improvement of memory loss in AD [ 17 , 18 , 19 ]. In addition, studies on the cholinesterase inhibitory activity of fruits and vegetables grown in Korea are insufficient, and there is a lack of data of comparative analysis of the antioxidants in blueberries according to the cultivar and maturity stage at harvest.…”

Influence of ripening stage and cultivar on physicochemical properties, sugar and organic acid profiles, and antioxidant compositions of strawberries

“…Phenolic compounds contained in foods have an antioxidant effect, and as such, they are expected to have a significant impact on improving memory function compromised by AD; this potential has been suggested by the findings of several studies (Kim et al, 2005;Orhan et al, 2004). AChE and BChE have been performed by Korean research groups, including: comparative analysis of the AChE inhibitory activities of edible plant extracts, including Angelica gigas and Siberian ginger (Jung et al, 2012a;2012b); analysis of the AChE inhibitory effects of green, puer, oolong, and black teas sold in Korea (Jeong et al, 2009); analysis of the AChE inhibitory effects of ginger, turmeric, and garlic (Jung et al, 2012a;2012b). Although these studies analyzed the AChE inhibitory effects of edible plants, most studies have been limited to medicinal plants.…”