A comparative study of five plateletpheresis machines in a tertiary care center of India: <scp>AmiCORE</scp> vs <scp>COM</scp>.<scp>TEC</scp> vs Haemonetics <scp>MCS</scp>+ vs Spectra Optia vs Trima Accel

Arcot, Priyadarsini Jayachandran; Kumar, K. Sunil; Coshic, Poonam; Andriyas, Vijay; Mehta, Vikas

doi:10.1002/jca.21838

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Platelets can be processed from whole blood donation (whole blood derived platelets) or by apheresis technology (single donor apheresis platelets, SDAP). The Trima Accel apheresis machine (version 6.0; Terumo Penpol Pvt Ltd., Thiruvananthapuram, India) has been the preferred equipment for plateletpheresis because of claims of better platelet yield, collection efficiency, collection rate, and low adverse donor reaction compared to other available apheresis equipment [ 1 , 2 ]. Troubles during the plateletpheresis procedure, either due to equipment or donor-related factors, can lead to the termination of the procedure and wastage of this scarce resource, resulting in higher production costs.…”

Section: Introductionmentioning

confidence: 99%

A Vexing Problem of Air Trapping in the Trima Accel During Plateletpheresis Procedure: Reflecting Our Experience in Troubleshooting

Routray¹,

Tripathy²

2023

Cureus

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Troubleshooting for any fault of apheresis equipment or kit is hardly addressed. Here, we report a unique problem of air trapping in a kit at two different positions leading to failure of the plateletpheresis procedure. Two plateletpheresis procedures were aborted due to “Access pressure low”, though the needle position was absolutely perfect. In the third event, platelet yield was not increasing even after 30 minutes from the time of initiation. It was completed after stopping the centrifuge pump which could have displaced the air bubble from the collection port. The root cause for these events was analyzed in consultation with the apheresis technical expert and “air block” was found to be the cause. Air block can also result in a “low access pressure” alarm despite improper phlebotomy being the common cause. Perfect kit loading, checking of tubing defects prior to loading, and comparative analysis of troubleshooting to have adequate knowledge are essential tools for the smooth functioning of apheresis.

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Section: Introductionmentioning

confidence: 99%

A Vexing Problem of Air Trapping in the Trima Accel During Plateletpheresis Procedure: Reflecting Our Experience in Troubleshooting

Routray¹,

Tripathy²

2023

Cureus

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“…In comparison to random donor platelet concentrates separated of whole blood (WB) collections, SDPs have been observed to have certain advantages such as better platelet yield, lesser cellular contamination and transfusion reactions, as well as limited donor exposure, thereby reducing the risk of transfusion-transmitted infections and alloimmunization and have few disadvantages such as higher cost and increased time required for collection. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

Effect of donor parameters and cell separators on yield of apheresis platelet and their impact on corrected count increment in aplastic anemia patients

Yadav,

Srivastava,

Das

et al. 2023

Asian J Transfus Sci

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BACKGROUND: The new cell separators make it simple to collect single donor platelets (SDP), although the platelet yield may vary depending on the cell separator used and donor-related clinical and laboratory variables. AIMS: This study aims to study the factors affecting SDP yield and corrected count increment (CCI). MATERIALS AND METHODS: This retrospective study was carried out at a tertiary care facility in northern India, over 4 years (May 2017–April 2020), data were retrieved and analyzed. STATISTICAL ANALYSIS: Categorical variables were presented as proportions, while continuous variables were presented as mean with standard deviation, P < 0.05 was considered significant. RESULTS: We found a positive correlation between predonation platelet count and yield ( r = 0.243, P = 0.000). No such significant correlation was found with Hb concentration ( r = 0.025, P = 0.720), age ( r = 0.016, P = 0.820), sex ( r = −0.038, P = 0.584), and weight ( r = −0.025, P = 0.714). Maximum platelet yield and minimum time were seen with Trima. Only 39.3% (33/84) meet the 24 h CCI. The majority of patients did not meet the desired CCI could be due to the patients’ clinical condition. On logistic regression, we found a significant association of 24 h CCI with product yield (odds ratio [OR] = 0.168, P = 0.015) and posttransfusion platelet count (OR = 0.454, P < 0.05). CONCLUSION: The only donor-related factor that influences yield is predonation platelet count, whereas 24 h CCI may depend on the clinical status of the patient and yield.

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Quality validation of platelets obtained from the Haemonetics and Trima Accel automated blood-collection systems

Wang

Liao

Lin³

et al. 2021

Transfusion Clinique et Biologique

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Background: Platelet transfusion is required to treat haemo-oncology or trauma patients. Platelet apheresis (PPH) performed with apheresis equipment has increased rapidly in recent years. Leucocyte-reduced platelet apheresis (LRPH) can reduce the risk of platelet refractoriness and febrile nonhemolytic transfusion reactions (FNHTRs) for transfusion. Accordingly, this study aimed to investigate and compare the platelet metabolic and functional responses between PPH performed with Haemonetics and LRPH performed with Trima Accel cell separator. Methods: The qualities of platelets collected through PPH and LRPH were evaluated in terms of visual appearance, morphology, platelet-aggregation changes, metabolic activities, and bacterium-screening test during 5-day storage. Statistical analyses included two-sample t-test and generalised estimating equation(GEE) method. Results: During 5-day storage in LRPH, residual leucocytes were all <1.0×10 6 , and the parameters of platelet function were as follows: platelet aggregated to agonists such as adenosine 5′-diphosphate (ADP) and collagen, and the extent of shape change and pO 2 showed no statistically signi cant difference between PPH and LRPH. The hypotonic shock reaction (HSR) on days 0, 1, and 3 were signi cantly higher in LRPH than in PPH (71.78±6.92 vs. 64.10±7.42; p=0.002; 71.53±8.98 vs. 62.96±9.84; p=0.007; 68.05±7.28 vs. 57.76±6.80; p<0.0001, respectively). Values of mean platelet volume (MPV) were statistically larger in PPH than in LRPH on days 0, 1, and 3. On day 5, the swirling score was higher in LRPH than in PPH. The mean lactate levels had no statistically signi cant difference between PPH and LRPH. Moreover, no growth was observed through bacterium-screening test conducted on 40 samples. Conclusion: Comparison of LRPH and PPH products collected from the Trima Accel and Haemonetics automated blood-collection systems, respectively, revealed that both products possessed good platelet qualities even though additional processes are needed to reduce leucocytes. Furthermore, investigating the outcomes of other apheresis instruments with focus on the safety of donors, products, and recipients is necessary.

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A comparative study of five plateletpheresis machines in a tertiary care center of India: AmiCORE vs COM.TEC vs Haemonetics MCS+ vs Spectra Optia vs Trima Accel

Cited by 4 publications

References 22 publications

A Vexing Problem of Air Trapping in the Trima Accel During Plateletpheresis Procedure: Reflecting Our Experience in Troubleshooting

A Vexing Problem of Air Trapping in the Trima Accel During Plateletpheresis Procedure: Reflecting Our Experience in Troubleshooting

Effect of donor parameters and cell separators on yield of apheresis platelet and their impact on corrected count increment in aplastic anemia patients

Quality validation of platelets obtained from the Haemonetics and Trima Accel automated blood-collection systems

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