A comparative study of effect on reducing pain, inflammation and side effect of combination of enzymes (bacterial proteases, papain, bromelain, vitamin C and rutin) versus conventional non-steroidal anti-inflammatory drugs (diclofenac) in patients of closed fracture lower end radius coming at orthopaedic department of a tertiary care hospital

Acharya, Tejas; Trivedi, Madhav; Mehta, Dimple S.; Chhaiya, Sunita B.; Gandhi, Shreyas

doi:10.18203/2319-2003.ijbcp20161562

Cited by 2 publications

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The combination was reported to be safer than diclofenac. 9 A pooled re-analysis of data from 6 trials in 774 knee OA patients, confirmed these results, but also identified that although enzyme therapy did not lead to laboratory value derangements, diclofenac treatment led to changes in key hepatic enzymes in ~72.6% and red blood parameters in ~86.3% of patients. 10 This is further supported by compiled data from multiple studies that indicate that the enzyme-flavonoid combination is safer than NSAIDs.…”

Section: Discussionmentioning

confidence: 81%

Oral enzyme therapy using trypsin-bromelain-rutoside combination to counter pain and swelling in orthopaedic conditions: a single-centre experience

Dhadiwal

Khemnar²,

John³

2022

Int J Res Orthop

View full text Add to dashboard Cite

Background: Various orthopaedic conditions end up being painful, chronic and progressive, and are associated with persistent inflammation. The present study aimed to evaluate the efficacy and safety of an enzyme-bioflavonoid combination of trypsin-bromelain-rutoside in managing the chronic pain and swelling in out-patients with various orthopaedic conditions.Methods: The study was a prospective, observational study, conducted in 100 patients attending the orthopaedics department at a multi-speciality hospital located in Nashik, Maharashtra, India. Verbal rating scales were used for grading the pain intensity and extent of swelling at baseline and on days 3 and 8, after being prescribed oral tablets of trypsin-bromelain-rutoside combination. Scores were analysed using paired t test. A 5-point Likert scale was used to evaluate patient- and investigator-reported global assessment of improvement in pain and swelling at days 3 and 8.Results: At baseline, 68 patients reported moderate-severe pain, while 74 patients had moderate swelling. The mean scores for pain and swelling showed statistically significant reduction at both day 3 (p<0.0001) and day 8 (p<0001). By day 8, 98 patients reported good-excellent improvement and the investigator reported good-excellent improvement in 97 patients. No adverse event was reported by any patient.Conclusions: The results indicate that this therapy led to significant improvement in the pain and swelling as early as day 3 and further improvement with continued therapy, and can, thus, provide a safe alternative in patients with various orthopaedic conditions and reduce the need for other analgesic and anti-inflammatory drugs.

show abstract

Section: Discussionmentioning

confidence: 81%