A Comparative Study of Effect of Ormeloxifene and Evening Primrose Oil in Treatment of Mastalgia

Nigam, Anjana; Goenka, Ashish; Shrivastava, Nikita

doi:10.1007/s12262-018-1793-5

Cited by 5 publications

(7 citation statements)

References 14 publications

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“…Ormeloxifene is more effective than evening primrose oil in long term in the treatment of mastalgia. 4 There was significant relief of mastalgia in both groups in our study. Patients in centchroman group experienced early alleviation of mastalgia as compared to patients in evening primrose oil group.…”

Section: Discussionsupporting

confidence: 56%

“…Pain may arise from myofascial pain syndromes, bonylesions. 4 Other cause of non-cyclical breast pain include alcoholism with liver damage (likely due to abnormal steroid metabolism), mastitis and drugs such as estrogen, progesterone, oral contraceptive, digitalis, methyldopa (an antihypertensive), spironolactone, diuretics, oxymetholone (an anabolic steroid), ketoconazole, metronidazole, cimetidine, cyclosporine and chlorpromazine (a typical antipsychotic). Also, shingles can cause painful blistering rash on the skin of the breasts.…”

Section: Introductionmentioning

confidence: 99%

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A comparative study of centchroman versus evening primrose oil in treatment of mastalgia

2020

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Background: Breast pain or mastalgia is one of the most common symptoms presenting to general surgeons. Approximately 60-70% of the women experience some type of breast pain at some point of their lives. Mastalgia may be classified as cyclical and non-cyclical. In cyclical mastalgia the pain intensity is changing during the menstrual cycle. In non-cyclical mastalgia there is no other obvious cause present, the pain is considered to be originating from the breast and the pain remains unchanged during the menstrual cycle. If the pain persists there are a variety of pharmacological agents for treatment of mastalgia. These include 3-6 months course of low dose tamoxifen (10 mg) or evening primrose oil. Other agents include bromocriptine and danazol but are obsolete now days. Newer treatments include centchroman and topical non-steroidal anti-inflammatory preparations. In pursuit of finding an effective safe and economical agent to treat it, plan to compare centchroman to evening primrose oil as treatment of mastalgia.Methods: In this study, two groups with 40 patients each will be taken and treatment will be given for 12 weeks and follow up to 24 weeks will be done without medication to assess sustained response or recurrence of mastalgia.Results: Centchroman is a non-steroidal drug found to be effective in the treatment of mastalgia with early and better relief in a time period of 3 months with minimal side effects as compared to evening primrose oil.Conclusions: This study has demonstrated that Centchroman therapy offers safe, effective and economical alternative to Evening Primrose oil for treatment of mastalgia.

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

A comparative study of centchroman versus evening primrose oil in treatment of mastalgia

2020

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“…in their study reported that Centchroman was used for treating benign breast diseases, fibroadenoma, mastalgia, and nodularity. [ 16 ]…”

Section: Discussionmentioning

confidence: 99%

A Study Comparing Centchroman and Evening Primrose Oil in the Treatment of Benign Breast Disease

Sinha,

Tajdar,

Pankaj

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Introduction: Females seeking medical attention at breast clinics commonly present with nonmalignant breast conditions, including nonspecific breast pain or distinct masses like fibroadenomas. Due to its variability, it may be difficult to quantify breast pain. The purpose of the research was to compare centchroman and evening primrose oil to identify a cost-effective, secure, and efficient treatment for benign breast disease. Material and Methods: In this prospective hospital-based observational study, 100 breast diseases with or without lumpiness for 1 year were included and divided into two groups with 50 cases each, Group-A (Centchroman) and Group-B (Evening primrose oil). Results: Centchroman exhibited a significantly greater treatment response for alleviating pain-free mastalgia compared to evening primrose oil. Additionally, centchroman showed an excellent response (P < .05). Among participants with mastalgia, centchroman significantly reduced the number of mastalgia patients with tender nodularity post-treatment (P = .035) than evening primrose oil. On the basis of fibroadenoma, partial and complete response was significantly seen in higher number of cases in the centchroman group (P = .007). Conclusion: Centchroman therapy demonstrates that the treatment for benign breast disease is safe, effective, and economical.

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“…7 Similarly, Nigam et al, in a prospective comparative study of 90 consecutive patients of mastalgia, found ormeloxifene to be more effective than evening primrose oil in the treatment of mastalgia in the long term. 8 Uma et al, in 2004, noted in a small number of patients labeled as refractory mastalgia, where >94% turned out to respond with dietary modifications coupled with reassurance. 9 In a large (n=1000) observational study in Pondicherry, India, Janaki et al, in 2016, showed that self-breast examination to be poorly understood and clinical breast examination is still the gold standard and more fruitful in combination with USG and FNAC.…”

Section: Discussionmentioning

confidence: 99%

An observational study comparing ormeloxifene with evening primrose oil for benign breast diseases

2023

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Background: Fibroadenosis, popularly termed aberrations of normal development and involution (ANDI), is by far the most common female breast presentation to a surgeon. ANDI accounts for the most common breast lumps in women <30 years of age. Mastalgia, a significant spectrum of ANDI, is usually classified as (1) cyclical mastalgia (more common) and (2) non-cyclical mastalgia. Breast nodularity, the other spectrum of ANDI may either present as a predominant feature or coexist with mastalgia. Aims and Objectives: The aims of this study were to comparatively study ormeloxifene and evening primrose oil with respect to regression of fibroadenosis and mastalgia and evaluate their side effects. Materials and Methods: This prospective study was conducted in the Department of General Surgery of Calcutta National Medical College and Hospital, Kolkata from February 15th, 2021 to February 14th, 2022, after obtaining prior Institutional Ethical Committee Clearance. Two hundred and eighty patients were equally divided into two groups of 140 in each and screened for inclusion in this study. Results: At the start of treatment, Group A (Ormeloxifene) presented with a mean visual analog scale (VAS) score value of 5.71, while patients of Group B presented with a similar mean VAS score value of 5. Group B recorded a VAS score of 4.50 at the end of the 6th month, while Group A recorded a significant downhill slope of negligible mean VAS score value of 0.80 at the of the 6th month. In breast nodularity gradings too, Group A showed significant down staging of grades returning, 95% confidence interval at the end of 6th month as 1.144, while 2.280 was recorded for Group B. Conclusion: Benign breast disease is a common presenting problem in females of reproductive age. Ormeloxifene can be a better alternative to evening primrose oil in both cyclical and non-cyclical types of mastalgia. Larger trials are however required, to finally conclude on.

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A Comparative Study of Effect of Ormeloxifene and Evening Primrose Oil in Treatment of Mastalgia

Cited by 5 publications

References 14 publications

A comparative study of centchroman versus evening primrose oil in treatment of mastalgia

A comparative study of centchroman versus evening primrose oil in treatment of mastalgia

A Study Comparing Centchroman and Evening Primrose Oil in the Treatment of Benign Breast Disease

An observational study comparing ormeloxifene with evening primrose oil for benign breast diseases

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