A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

Kim, Hong Kee; Lee, Soo Hyun; Lee, Boo Yong; Kim, Sung Jin; Sung, Chang Yub; Jang, Na Keum; Kim, Jung Dong; Jeong, Do Hyeon; Ryu, Hyeon Yeol; Lee, Somin

doi:10.1039/c8bm00768c

Cited by 34 publications

(13 citation statements)

References 33 publications

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“…Our data show that the penetration efficiency of dMNAs in the skin increased by mixing pullulan with trehalose, irrespective of the percentage of pullulan. Various polymers such as polyvinyl alcohol 36 , hyaluronic acid 37 , or polyvinylpyrrolidone 38 can also be mixed with trehalose to increase the mechanical strength of microneedles. However, the advantage of using pullulan over these polymers is that the trehalose/pullulan mixture has high antigen stabilizing properties 19 .…”

Section: Discussionmentioning

confidence: 99%

Intradermal Administration of Influenza Vaccine with Trehalose and Pullulan-Based Dissolving Microneedle Arrays

Tian

Lee

Maaden

et al. 2022

Journal of Pharmaceutical Sciences

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Section: Discussionmentioning

confidence: 99%

Intradermal Administration of Influenza Vaccine with Trehalose and Pullulan-Based Dissolving Microneedle Arrays

Tian

Lee

Maaden

et al. 2022

Journal of Pharmaceutical Sciences

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“…Hyaluronic acid (HA) is a kind of macromolecular anionic polymer existing in the biological body, which is widely used in medicine, the cosmetics industry, and other biomedical applications [ 1 ]. It is endogenous, biocompatible, hydrophilic, viscoelastic, well tolerated, and therapeutic.…”

Section: Introductionmentioning

confidence: 99%

Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery

Huang

Yang

2022

International Journal of Analytical Chemistry

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The common feature of non-cross-linked hyaluronic acid nano-needles is that they penetrate the skin and dissolve rapidly, and the non-cross-linked hyaluronic acid will migrate under the skin, so it is difficult to maintain the long-term expansion effect in a fixed position. In order to achieve the relatively long-term antiwrinkle effect, a kind of cross-linked and non-cross-linked compound hyaluronic acid microne was prepared. By inserting the microne under the skin, dissolving the non-cross-linked part under the skin and introducing the cross-linked gel particles under the skin, the effect of extending the microne was achieved. The mechanical properties, permeability, and degradation rate of cross-linked and non-cross-linked hyaluronic acid composite nano-needles were studied in detail. Experimental results show that the higher the content of CHA, the slower the degradation rate of the microneedle, and the skin swelling of the HA_CHA (1 : 1) microneedle is the most lasting. With the increase of CHA content in microneedle matrix materials, the degree of epidermal expansion decreased. The preparation of cross-linked and non-cross-linked hyaluronic acid microneedles has the potential to be effectively used as dermal fillers in cosmetics or antiaging treatments.

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“…The dissolution rate of F1 formulation, which contained no trehalose, was relatively slow during in vitro drug release study, because trehalose accelerates drug release from DMNs [35]. Since the mechanical properties of DMN are improved upon the incorporation of trehalose [36], it is reasonable to exclude F1 in terms of microneedle fabrication and skin application. Because of its high water absorption capacity, PVP promotes rapid DMN dissolution and can, thus, improve drug bioavailability [37].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, this DMN formulation was adopted as the final formulation. Accelerating the drug release from DMNs is an essential strategy to improve drug bioavailability [36].…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Evaluation of a Novel Donepezil-Loaded Dissolving Microneedle Patch in Rats

et al. 2021

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Research on the development of dissolving microneedles (DMNs) has focused on bolus drug delivery, with little attention on sustained release. Here, we evaluated the sustained release, absorption pattern, and effective drug permeation of a novel donepezil-loaded DMN patch through an in vivo investigation on rats. The applications of DMN patches to the shaved skin of rats for 1 week and 1 h were compared with oral donepezil administration to assess their sustained release capabilities. We used a validated liquid chromatography–tandem mass spectrometry method to quantify donepezil in the plasma. We found that the microneedle arrays effectively delivered donepezil across the skin, with dissolution observed within 1 h of application. Furthermore, skin irritation test showed that the patches produced no irritation response. The DMN arrays also effectively increased drug permeation and demonstrated sustained release and absorption of donepezil from DMN patches. These patches allow extended dosing intervals, reduced gastrointestinal adverse effects, and convenient self-administration to mitigate poor drug compliance, making them beneficial for the treatment of elderly patients with Alzheimer’s disease.

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A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

Cited by 34 publications

References 33 publications

Intradermal Administration of Influenza Vaccine with Trehalose and Pullulan-Based Dissolving Microneedle Arrays

Intradermal Administration of Influenza Vaccine with Trehalose and Pullulan-Based Dissolving Microneedle Arrays

Application of Cross-Linked and Non-Cross-Linked Hyaluronic Acid Nano-Needles in Cosmetic Surgery

Pharmacokinetic Evaluation of a Novel Donepezil-Loaded Dissolving Microneedle Patch in Rats

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