A comparative study of different crude extracts of<i> Ocimum sanctum</i> on noise stress

Archana, R; Ambalavanan, Namasivayam

doi:10.1002/ptr.1018

Cited by 9 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, experimental studies have shown that tulsi helps reduce the effects of acute and chronic noise-induced stress in experimental animals, with enhancement of neurotransmitter and oxidative stress levels in discrete brain regions along with improved immune, ECG and corticosteroid responses. [ 42 43 44 45 ]…”

Section: Introductionmentioning

confidence: 99%

Tulsi - Ocimum sanctum: A herb for all reasons

Cohen

2014

J Ayurveda Integr Med

329

183

View full text Add to dashboard Cite

The predominant cause of global morbidity and mortality is lifestyle-related chronic diseases, many of which can be addressed through Ayurveda with its focus on healthy lifestyle practices and regular consumption of adaptogenic herbs. Of all the herbs used within Ayurveda, tulsi (Ocimum sanctum Linn) is preeminent, and scientific research is now confirming its beneficial effects. There is mounting evidence that tulsi can address physical, chemical, metabolic and psychological stress through a unique combination of pharmacological actions. Tulsi has been found to protect organs and tissues against chemical stress from industrial pollutants and heavy metals, and physical stress from prolonged physical exertion, ischemia, physical restraint and exposure to cold and excessive noise. Tulsi has also been shown to counter metabolic stress through normalization of blood glucose, blood pressure and lipid levels, and psychological stress through positive effects on memory and cognitive function and through its anxiolytic and anti-depressant properties. Tulsi's broad-spectrum antimicrobial activity, which includes activity against a range of human and animal pathogens, suggests it can be used as a hand sanitizer, mouthwash and water purifier as well as in animal rearing, wound healing, the preservation of food stuffs and herbal raw materials and traveler's health. Cultivation of tulsi plants has both spiritual and practical significance that connects the grower to the creative powers of nature, and organic cultivation offers solutions for food security, rural poverty, hunger, environmental degradation and climate change. The use of tulsi in daily rituals is a testament to Ayurvedic wisdom and provides an example of ancient knowledge offering solutions to modern problems.

show abstract

Section: Introductionmentioning

confidence: 99%

Tulsi - Ocimum sanctum: A herb for all reasons

Cohen

2014

J Ayurveda Integr Med

329

183

View full text Add to dashboard Cite

show abstract

“…It reacts within split seconds to help the body adjust to this stressful situation by releasing hormones [2]. Researchers demonstrated that noise exposure is a potent stressor that increases the levels of the stress hormone, corticosterone [6]. Noise stress effects are not sudden and catastrophic but gradual and insidious [2].…”

Section: Introductionmentioning

confidence: 99%

Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats

Haider

Naqvi²,

Batool³

et al. 2012

Sci. Pharm.

View full text Add to dashboard Cite

Mankind is exposed to a number of stressors, and among them noise is one which can cause intense stress. High levels of background noise can severely impair one’s ability to concentrate. The present study was aimed to investigate the effect of sub-chronic noise stress on cognitive behavior and hippocampal monoamine levels in male rats. The study was performed on 12 male Wistar rats, divided into two groups; the control and noise-exposed. The rats in the test group were subjected to noise stress, 4h daily for 15 days. Cognitive testing was performed by the Elevated Plus Maze test (EPM) and Novel Object Recognition test (NOR). HPLC-EC was used to determine hippocampal monoamine levels and their metabolites. The data obtained revealed a significant decrease in hippocampal serotonin (5-hydroxytryptamine; 5-HT) and dopamine (DA) levels, whereas turnover ratios of 5-HT and DA were significantly increased compared to the controls. Rats exposed to noise exhibited a significant decrement in spatial memory. A significantly decreased recognition index of rats exposed to noise as compared to the control was also observed in the NOR test. Results of the present findings suggest the role of decreased hippocampal 5-HT and DA in the impairment of cognitive function following noise exposure.

show abstract

“…Only the freshly prepared extract was used for the study. 8 Drugs: Following drugs and chemicals were used: indomethacin (Indocap, Jagsonpal Pharmaceuticals, India), phenytoin (M-Toin, Medopharm, India), sodium valporate (Encorate, Sun Pharmaceuticals, India), diazepam (Valium, Piramal Healthcare, India), pentylenetetrazole (Sigma Chemicals, USA), pentobarbitone sodium (LobaChemie, India), morphine (Martindale Pharmaceuticals, UK) and acetic acid (Qualigens fine chemical, India).…”

Section: Extract Preparation: Og Was Collected From Thickmentioning

confidence: 99%

“…The dose of the test drug was chosen according to the study done Archana et al and Volume Guidelines for Compound Administration. 8,9 All standard drugs were administered to the animals through oral route 45 minutes before the experiments. The experiment was conducted on 7th day, 45 minutes after the last test drug administration.…”

Section: Experimental Designmentioning

confidence: 99%

Effect of leaf extract of ocimum gratissimum on central nervous system in mice and rats

2014

View full text Add to dashboard Cite

Background: Ocimum gratissimum, known as “Ram Tulsi”, is one of medicinal herbs used in traditional medicinal practice in our country. Objective: To observe and evaluate various central nervous system activities of cold homogenized leaf extract of Ocimum gratissimum (OGE) in mice and rats. Methods: OGE was given to albino mice (n=240) and Wistar rats (n=30) in three doses 5, 10 and 15 ml/kg for seven days and evaluated for antinociceptive, anticonvulsant, motor coordination, hypnotic and anxiolytic effect using respective experimental procedures. Distilled water was used as vehicle control and various drugs as standard control for comparison. Results: OGE showed significant (p<0.05) analgesic effect as compared to vehicle treatment in hot plate test. Pentobarbital-induced sleeping time was significantly (p<0.05) potentiated by OGE in rats. OGE significantly decreased duration of tonic hind limb extension at doses of 5 and 15ml/kg in MES test and increased latency to convulsion at dose of 15 ml/kg in PTZ-induced seizure test. OGE at dose of 5 and 10 ml/kg induced significant muscle relaxation. Time spent in central square and number of rearing increased in mice pretreated with OGE at 10 and 15 ml/kg. Conclusion: OGE possess antinociceptive, hypnotic-sedative potentiating, anxiolytic and muscle relaxant properties with probable anticonvulsant properties. DOI: http://dx.doi.org/10.3126/hren.v11i3.9632 Health Renaissance 2013;11(3):198-204

show abstract

A comparative study of different crude extracts of Ocimum sanctum on noise stress

Cited by 9 publications

References 4 publications

Tulsi - Ocimum sanctum: A herb for all reasons

Tulsi - Ocimum sanctum: A herb for all reasons

Decreased Hippocampal 5-HT and DA Levels Following Sub-Chronic Exposure to Noise Stress: Impairment in both Spatial and Recognition Memory in Male Rats

Effect of leaf extract of ocimum gratissimum on central nervous system in mice and rats

Contact Info

Product

Resources

About