A comparative study of dexmedetomidine and diltiazem for attenuating pressor responses to laryngoscopy and endotracheal intubation: A double-blind, randomized study

Abstract

Context:Endotracheal intubation has been suggested to be one of the most invasive stimuli in anesthesia, particularly during induction and after tracheal intubation. The present study aims to evaluate the efficacy of dexmedetomidine as compared to diltiazem on hemodynamic response to laryngoscopy and intubation.Aims:To assess and compare the hemodynamic response of dexmedetomidine as compared to diltiazem in patients undergoing laryngoscopy and intubation and rate and type of side effects of the drugs if any.Settings and Design:This study design was a prospective, randomized, and double-blind trial.Subjects and Methods:The patients were randomly allocated into three groups: Group I (control), Group II (dexmedetomidine), and Group III (diltiazem) of 45 patients each. Group I (n = 45): 0.9% NaCl 10 ml was given to the patients over 10 min before intubation in Group I (control). Group II (n = 45): injection dexmedetomidine (0.5 μg/kg) in 10 ml normal saline was given to the patients over 10 min before intubation. Group III (n = 45): injection diltiazem (0.3 mg/kg) in 10 ml normal saline was given to the patients over 10 min before intubation.Statistical Analysis Used:The data so collected were subjected to statistical analysis using Statistical Package for the Social Sciences version 15.0.Results:Mean percentage increase in systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) following intubation was 17.90%, 19.96%, and 19.04%, respectively, in control group, 9.04%, 6.32%, and 7.53%, respectively, in dexmedetomidine group, and 12.30%, 10.32%, and 11.14%, respectively, in diltiazem groups. Statistically, there was a significant difference in postintubation SBP, DBP, and MAP of the three groups (P < 0.001). Dexmedetomidine at a dose of 0.5 μg/kg showed to have a better attenuation of pressor response as compared to diltiazem at a dose of 0.3 μg/kg.Conclusions:Both dexmedetomidine and diltiazem were safe and effective in attenuating the hemodynamic response following laryngoscopy and endotracheal intubation; however, between two trial drugs, dexmedetomidine had a better response.

Efficacy of combination of esmolol and diltiazem for attenuating hemodynamic response to laryngoscopy and intubation: A prospective randomized study

“…found that diltiazem (0.3 mg/kg) did not attenuate the increase in HR, when administered alone. [ 15 16 ] This was in contrast to a study by Sarkar et al . which showed that attenuation in HR response after laryngoscopy was comparable between diltiazem and esmolol.…”

Effect of Remifentanil Bolus vs Fentanyl in Attenuating Hemodynamic Response in Videolaryngoscopic Endotracheal Intubation

“…Loss of airway patency, loss of protective airway reflexes, hypoventilation, and apnea are all possible impact of general anesthesia on respiratory system, therefore one of the fundamental aim of a safe anesthesia technique is maintaining a secure airway (1) . Although endotracheal tube remain the gold standard airway device, but its placement is known to elicit stress response (2) .…”

Retraction: A comparative study of dexmedetomidine and diltiazem for attenuating pressor responses to laryngoscopy and endotracheal intubation: A double-blind, randomized study

“…The original article titled “A Comparative Study of Dexmedetomidine and Diltiazem for Attenuating Pressor Responses to Laryngoscopy and Endotracheal Intubation: A Double-blind, Randomized Study” published in Anesthesia Essays and Researches, on pages 921-929, Issue 4, Volume 11, 2017[ 1 ], is being retracted due to author conflict. This has been brought to notice of the Editor-in-Chief, by the authors.…”