A comparative study of conventional pap smear with liquid based cytology for early diagnosis of cervical cancer

Aboobacker, Kalathingal Kamarunisha; Shariff, Mariam

doi:10.18231/j.achr.2020.029

Cited by 4 publications

(1 citation statement)

References 21 publications

(36 reference statements)

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“…Чутливість виявлення патології, яка в подальшому підтверджувалась гістологічно, при рідинному Пап-тесті була вищою порівняно з традиційним (96,2% проти 92,0%), різниця в специфічності була незначною (97,8% проти 98,2%) [19]. Подібні результати були отримані і в пізніших дослідженнях [20][21][22].…”

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The cytological component of cervical cancer screening: causes of false negative and false positive results, and ways to avoid them

Бурка

Lygyrda

Kutsovol³

et al. 2021

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Cervical cancer (CC) screening is a major component of secondary prevention of CC and involves screening all women at risk of developing this disease, most of whom are asymptomatic. Cytology remains an important component of CC screening in the era of primary screening by genotyping the human papillomavirus. Papanikolaou staining is the method of choice for CC screening. This review highlights the causes of false negative results for various methods of Pap tests and how they can be prevented. A detailed analysis of conditions accompanied by a high probability of false positive abnormal results of the Pap test, an explanation of the pathophysiological basis of this phenomenon, clinical and cytological criteria for differential diagnosis is also presented.Pap test is a screening test. The aim of the cytological examination in CC screening is to assign the patient to a group with absent neoplastic changes in the cervical epithelium, a group with neoplastic changes in the cervical epithelium present, or a group when it is impossible to make an accurate differential diagnosis between benign reactive changes and neoplasia. The Bethesda Cytology Reporting System is used to unify and standardize these categories in most countries of the world. Benign conditions are a common cause of false positive reports of cellular atypia on cervical screening, as evidenced by a large number of studies. This fact should be taken into account both in the interpretation of the results and, if possible, in the planning of cervical screening. The most common conditions that are accompanied by reactive changes in the cervical epithelium, which can be incorrectly assessed as atypia, are: reactive and reparative inflammatory changes, atrophy, metaplasia, reactive changes caused by intrauterine devices. In this regard, when working with the cytological component of cervical screening, it is important for the clinician to understand the basic principles of assessing the cervical epithelium, which will allow using the descriptive part of the report to determine tactics if a false negative or false positive screening result is suspected.Thus, understanding the impact of common benign conditions on the cervical epithelium makes it possible to rationally plan cytological cervical screening and correctly interpret its results in order to achieve the best clinical results that are not limited to the detection of precancerous conditions.

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The cytological component of cervical cancer screening: causes of false negative and false positive results, and ways to avoid them

Бурка

Lygyrda

Kutsovol³

et al. 2021

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Should Liquid-Based Cytology (LBC) be Preferred than Conventional Pap Smear (CPS): A Comparative Analysis

Andola,

Andola

et al. 2024

J Obstet Gynecol India

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Comparing the Effectiveness of Liquid Based Cytology (Lbc) With Conventional Pap Smear: A Prospective Study

Saxena

Rai

Shrivastava

et al. 2022

PIJR

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Background: Cervical cancer is unique among human cancers which is mostly attributable to infection. Conventional PAP smear method is most effective for prevention and detection of cervical cancer but the accuracy of this method is low.This PAP smear now evolved to Liquid Based Cytology (LBC). Method:All the patients visiting Gynaecology OPD who fulfilled the inclusion Criteria in the duration starting from 1 January 2020 to 30 June 2021 in the Department of Pathology of Gajra raja Medical College, Gwalior (MP) were included in this study. 50 atypical smears by Conventional PAP test were then collected and these cases were subjected to Eziprep Liquid Based Cytology and Conventional PAP smear in private laboratory setup after taking history and clinical examination. The smears were studied by using 7 morphological parameters. Result: Smears were analysed for adequate cellularity, clean background, uniform distribution of cells,cellular overlapping,inflammation,distinct cell border,nuclear irregularity and then categorise by Bethesda reporting system.The results were significant only for clean background,uniform distribution of cells,cellular overlapping and inflammation. Conclusion: Results of cervical cytology smears by both methods showed that LBC provides more representative sample with reduced obscuring material,improved clarity allowing better morphological evaluation.

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A comparative study of conventional pap smear with liquid based cytology for early diagnosis of cervical cancer

Cited by 4 publications

References 21 publications

The cytological component of cervical cancer screening: causes of false negative and false positive results, and ways to avoid them

The cytological component of cervical cancer screening: causes of false negative and false positive results, and ways to avoid them

Should Liquid-Based Cytology (LBC) be Preferred than Conventional Pap Smear (CPS): A Comparative Analysis

Comparing the Effectiveness of Liquid Based Cytology (Lbc) With Conventional Pap Smear: A Prospective Study

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