A comparative study of continuous operation between a dynamic baffle crystallizer and a stirred tank crystallizer

Liu, Yiqing C.; Dunn, Davis; Lipari, Mary; Barton, Alastair; Firth, Paul; Speed, Jonathon; Wood, Dan; Nagy, Zoltán K.

doi:10.1016/j.cej.2019.02.129

Cited by 30 publications

(34 citation statements)

References 52 publications

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“…COBC. More recently, Liu et al [37] utilised in-situ Fourier transform infrared (FTIR) spectroscopy to characterise the RTD of a dynamic baffle OBR.…”

Section: Highermentioning

confidence: 99%

Solid-liquid axial dispersion performance of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions using a non-invasive dual backlit imaging technique

Onyemelukwe

Nagy

Rielly

2020

Chemical Engineering Journal

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A dual backlit imaging technique has been developed for liquid and solid phase residence time distribution (RTD) measurements in a mesoscale (millilitre) continuous oscillatory flow crystalliser with smooth periodic constrictions (herein known as the SPC mesoscale crystalliser). The pixel-based technique enables reliable determination and direct comparison of experimentally determined hydrodynamic parameters for the liquid and solid phase without concern for errors that may be introduced by utilising different measurement techniques for each phase. Additionally, the non-invasive technique offers benefits over traditional intrusive methods as demonstrated herein. Results of solid-liquid RTD experiments reveal that for a set of oscillatory flow conditions, particles do not experience the same degree of axial dispersion and mean residence time as the continuous liquid phase. The SPC mesoscale crystalliser, however, provides solid-liquid plug flow at low net flow rates. Findings in this work emphasise the importance of characterising solid phase axial dispersion for active pharmaceutical ingredient (API) systems during continuous crystallisation development to identify minimum dispersion operating conditions essential for solid-liquid plug flow crystallisation.

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“…COBC. More recently, Liu et al [37] utilised in-situ Fourier transform infrared (FTIR) spectroscopy to characterise the RTD of a dynamic baffle OBR.…”

Section: Highermentioning

confidence: 99%

Solid-liquid axial dispersion performance of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions using a non-invasive dual backlit imaging technique

Onyemelukwe

Nagy

Rielly

2020

Chemical Engineering Journal

Self Cite

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“…Continuous feed transfer between vessels can be done by pressure, 34 vacuum or pump. 20 Pump transfer was deliberately avoided in this setup to minimise any effect on solids due to the mechanical force exerted by the moving parts of the pump. Pressure transfer was implemented by maintaining the CMBOC under positive pressure of 0.02 to 0.05 bar.…”

Section: Development Of Continuous Crystallisation Platformmentioning

confidence: 99%

“…The feed transfer occurs from the top of each stage to the bottom of the next stage to avoid short-circuiting of the fluid between inlet and outlet. 20 There are also two ports available in the middle of each vessel to incorporate PAT probes or for sampling. Both ports are positioned in between two moving baffles.…”

Section: Development Of Continuous Crystallisation Platformmentioning

confidence: 99%

“…This has implications on the uniformity of growth, purification, attrition and agglomeration observed in the product. 8,19,20 PFRs are generally favoured for fast processes with short residence times and can achieve uniform mixing and heat transfer, which is often critical to achieve a well-controlled crystallisation process. For slower processes, such as crystallisation, a very long plug flow crystalliser is usually required to meet the longer residence time requirements and satisfy the flow rates required to achieve plug flow.…”

Section: Introductionmentioning

confidence: 99%

“…31 Yiging C. Liu et al showed that the MBOC has considerable potential in comparison to a traditional STC to produce narrow product particle size distributions in addition to offering stable and reliable cooling crystallisation operation in a single stage MSMPR in continuous mode. 20 The CMBOC has a number of potential benefits that include handling high solid loadings via control of oscillatory conditions. More uniform mixing is achieved compared with a stirred tank by distributing the moving baffles uniformly throughout each vessel.…”

Section: Introductionmentioning

confidence: 99%

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