A comparative study of combined dermaroller and platelet-rich plasma versus dermaroller alone in acne scars and assessment of quality of life before and after treatment

Abstract

Background:Scarring due to acne is a frequently encountered problem in dermatological outpatient department. Microneedling has been a well-accepted modality for the treatment of atrophic acne scars. Platelet-rich plasma (PRP) is a newer option to investigate.Aims:The aims of this study were (1) to compare the efficacy of combined dermaroller and PRP therapy with dermaroller alone in facial acne scars and (2) to assess the psychosocial impact due to acne scars and its treatment.Methods:A total of 55 patients were included in the study and randomly divided into two groups, Group A: 28 and Group B: 27. Proper counseling was done, and detailed clinical findings were recorded. Patients in Group A were treated with dermaroller alone while Group B patients underwent treatment with a combination of dermaroller and intradermal PRP injections. A total of three sitting were done at monthly interval. Final response was assessed at 1 month after the last sitting. Criteria of evaluation included Goodman and Baron's quantitative scale, visual analog score, and dermatology life quality index scores. Side effects were noted. Results were analyzed using Chi-square test and t-test.Results:Significant percentage improvement was noted in both the groups. However, Group B treated with both modalities had better results when compared with that in the Group A.Conclusion:A combination approach using dermaroller and PRP was a safe and better option than using dermaroller alone in atrophic acne scars for clinical improvement as well as for improvement in dermatology life quality index score.

Platelet‐rich plasma in noninvasive procedures for atrophic acne scars: A systematic review and meta‐analysis

“…Although heterogeneity existed in the utilization of secondary outcomes, six of the eight trials used Goodman and Baron scores as the primary outcome. Two trials with an unclear risk of selective reporting used undocumented scales for primary outcome evaluation (Figure ) . While no studies reported a published protocol, there were no reporting discrepancies between methodology and results.…”

“…All included studies were either a comparative, simple randomized, noncontrolled study, 12,18,19 or a nonrandomized, controlled, beforeand-after study. 13,[20][21][22][23] The included study characteristics are summarized in Table 1.…”

“…Although heterogeneity existed in the utilization of (Figure 4). 19 While no studies reported a published protocol, there were no reporting discrepancies between methodology and results. Visual inspection of a funnel plot showed no signs of publication bias.…”

Inorganic Polyphosphates Are Important for Cell Survival and Motility of Human Skin Keratinocytes and Play a Role in Wound Healing

“…In recent years, PRP has gained traction in many different specialties including in dermatology where it is used to treat acne [102], scarring [103], and alopecia [104,105], in regenerative medicine where it is used to treat acute and chronic injuries to bone and cartilage [106,107], in orthopedics and sports medicine where it is used to treat rotator cuff tears, osteoarthritis of the knee, hamstring injuries, and Achilles tendinopathy [108][109][110], in dentistry where it is used during tooth extractions, periodontal surgery, and dental implant surgery [111,112], and more recently in wound healing to promote enhanced healing [113][114][115][116][117][118]. PRP is an autologous blood product generated from multiple rounds of centrifugation that serve to concentrate the number of platelets in plasma.…”

Platelet-rich plasma: The journey so far !

“…[ 35 ] In a study on 55 adult patients with atrophic acne scars, significantly better improvement and better dermatology life quality index (DLQI) scores were reported by the use of derma roller combined with PRP, compared with derma roller alone. [ 36 ]…”