A Comparative Study of Bone Marrow Squash and Wedge Aspiration Smears

Ahluwalia, Neeti Arora; Kakkar, Naveen; Kwatra, Kanwardeep Singh

doi:10.1007/s12288-020-01321-9

Cited by 1 publication

(2 citation statements)

References 13 publications

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“…One challenge is the significant heterogeneity between BMA slides based on the sample cellularity, presence/absence of bone marrow particles, and type of smear created (squash vs. wedge). 53,54 Intra-slide heterogeneity in cell composition within BMA slides also necessitates analyzing multiple regions of interest, requiring additional neural network models to identify such regions. 11 The bone marrow contains important cell types that are not often found in PB even in pathologic conditions, including early erythroid precursors, megakaryocytes, and plasma cells; BMA smear analyzers need to accurate classify these additional cell types, requiring more sophisticated machine learning models than those currently deployed for PB analysis.…”

Section: Challenges With Digital Bone Marrow Aspirate Assessmentmentioning

confidence: 99%

“…There are multiple additional challenges associated with digital BMA assessment compared to PB that have likely contributed to this absence of BMA smear instrumentation. One challenge is the significant heterogeneity between BMA slides based on the sample cellularity, presence/absence of bone marrow particles, and type of smear created (squash vs. wedge) 53,54 . Intra‐slide heterogeneity in cell composition within BMA slides also necessitates analyzing multiple regions of interest, requiring additional neural network models to identify such regions 11 .…”

Section: Digital Analysis Of Bone Marrow Aspirate Smearsmentioning

confidence: 99%

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Digital assessment of peripheral blood and bone marrow aspirate smears

Lewis

Pozdnyakova

2023

Int J Lab Hematology

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The diagnosis of benign and neoplastic hematologic disorders relies on analysis of peripheral blood and bone marrow aspirate smears. As demonstrated by the widespread laboratory adoption of hematology analyzers for automated assessment of peripheral blood, digital analysis of these samples provides many significant benefits compared to relying solely on manual review. Nonetheless, analogous instruments for digital bone marrow aspirate smear assessment have yet to be clinically implemented. In this review, we first provide a historical overview detailing the implementation of hematology analyzers for digital peripheral blood assessment in the clinical laboratory, including the improvements in accuracy, scope, and throughput of current instruments over prior generations. We also describe recent research in digital peripheral blood assessment, particularly in the development of advanced machine learning models that may soon be incorporated into commercial instruments. Next, we provide an overview of recent research in digital assessment of bone marrow aspirate smears and how these approaches could soon lead to development and clinical adoption of instrumentation for automated bone marrow aspirate smear analysis. Finally, we describe the relative advantages and provide our vision for the future of digital assessment of peripheral blood and bone marrow aspirate smears, including what improvements we can soon expect in the hematology laboratory.

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Section: Challenges With Digital Bone Marrow Aspirate Assessmentmentioning

confidence: 99%

Section: Digital Analysis Of Bone Marrow Aspirate Smearsmentioning

confidence: 99%