A Comparative Study of Blood Volume in Dogs

Simultaneous Distribution of T-1824 and I131-Labelled Human Serum Albumin in Man 1

“…Recently, such an interpretation of the "T-1824 space" has been questioned. The challenges are based largely upon discordant volumes of distribution obtained after the simultaneous administration of T-1824 and labelled red blood cells (7)(8)(9)(10)(11)(12)(13)(14), or T-1824 and radioactive plasma proteins (15)(16)(17)(18). Although others have been unable to confirm these differences (19)(20)(21)(22), the reported divergences are in agreement, both in direction and magnitude.…”

“…First, there might be early abstraction of T-1824 by phagocytosis or staining of tissues (15,24,25). Secondly, a disproportionate loss of T-1824 might occur during mixing by penetration into erythrocytepoor (7-14, 25, 28) or even extravascular channels (16,17,(25)(26)(27)(28)(29). The first explanation rejects T-1824 as an adequate protein label; the second explanation questions the immediate distribution of the T-1824-albumin complex.…”

The Influence of Ionizing Radiation on the Body Fluid Compartments of Patients With Malignant Lymphoma 12

“…Therefore, in the studies here described all determinations were carried out simultaneously, and were repeated serially at given intervals. Furthermore, the reliability of the substances used in this study to measure the various fluid compartments, viz., deuterium oxide, inulin and I1,1-tagged human serum albumin has been confirmed by many workers (13,15,16,(23)(24)(25)(26)(27)(28)(29). The use of the volume of distribution of the thiosulfate ion as a measure of extracellular fluid volume has been suggested by Cardoza and Edelman (19) and in the present study there was excellent experimental agreement between the thiosulfate and inulin spaces whenever these two measurements were carried out simultaneously.…”

The Use of K42 or P32 Labeled Erythrocytes and I131 Tagged Human Serum Albumin in Simultaneous Blood Volume Determinations 1

“…The most commonly employed plasma soluble substance has been Evans blue dye, T-1824 (9), its successful usefulness depending on its presumed rapid and complete binding to the circulating albumin (10). Recently plasma proteins tagged with I'll have been used in the determination of blood volume (11)(12)(13).…”