A comparative study of antimicrobial activity of differently-synthesized chitosan nanoparticles against bovine mastitis pathogens

Orellano, María Soledad; Bohl, Luciana Paola; Breser, María Laura; Isaac, Paula; Falcone, R. Darío; Porporatto, Carina

doi:10.1039/d0sm01179g

Cited by 15 publications

(7 citation statements)

References 64 publications

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“…According to the literature data, nanoparticles such as silver [ 72 , 75 ], copper nanoparticles [ 72 , 75 ], zinc oxide nanoparticles [ 76 ], nanogels [ 4 ], and chitosan nanoparticles [ 77 , 78 ] have been reported to show positive results in bovine mastitis management. Such therapeutic techniques are gaining popularity as tools for managing S. aureus mastitis due to the antimicrobial activity, including antibiotic-resistant strains and antibiofim activity [ 4 ].…”

Section: Alternative Strategies—potential Solutionsmentioning

confidence: 99%

Alternatives to Antimicrobial Treatment in Bovine Mastitis Therapy: A Review

2023

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Despite preventive and therapeutic measures, mastitis continues to be the most prevalent health problem in dairy herds. Considering the risks associated with antibiotic therapy, such as compromised effectiveness due to the emergence of resistant bacteria, food safety issues, and environmental impact, an increasing number of scientific studies have referred to the new therapeutic procedures that could serve as alternatives to conventional therapy. Therefore, the aim of this review was to provide insight into the currently available literature data in the investigation of non-antibiotic alternative approaches. In general, a vast number of in vitro and in vivo available data offer the comprehension of novel, effective, and safe agents with the potential to reduce the current use of antibiotics and increase animal productivity and environmental protection. Constant progress in this field could overcome treatment difficulties associated with bovine mastitis and considerable global pressure being applied on reducing antimicrobial therapy in animals.

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Section: Alternative Strategies—potential Solutionsmentioning

confidence: 99%

Alternatives to Antimicrobial Treatment in Bovine Mastitis Therapy: A Review

2023

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“…isolated from milk from cows with clinical mastitis and found that the antimicrobial capacity of the formulation was equal to or greater than conventional antibiotics [ 18 ]. Furthermore, in another study, it was proven that smaller particles of Qo NPs have better antimicrobial activity on the development of S. aureus and S. xylosus strains [ 19 ].…”

Section: Relevant Sectionsmentioning

confidence: 99%

The Antimicrobial Applications of Nanoparticles in Veterinary Medicine: A Comprehensive Review

et al. 2023

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Nanoparticles (NPs) are nanoscaled particles sized from 1–100 nm, which can be composed of inorganic or organic compounds. NPs have distinctive morphology, size, structure, and surface features, which give them specific properties. These particular attributes make them interesting for biological and medical applications. Due to these characteristics, researchers are studying the possible aptness of numerous nanoparticles in veterinary medicine, such as the capacity to act as a drug delivery system. The use of these NPs as a possible bactericidal or bacteriostatic medication has been studied against different bacteria, especially multiresistant strains and the ones that cause mastitis disease. The antibiofilm property of these nanostructures has also already been proved. The antiviral activity has also been shown for some important viral animal diseases; the antifungal activity had been demonstrated against both pathogenic and mycotoxigenic species. Therefore, this review aimed to elucidate the main clinical and preventive veterinary applications of inorganic and organic nanoparticles.

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“…The present situation in the field of bacterial infection inhibition calls for nanotechnology and nanoscience with antibacterial characteristics [6,7] . Primarily it has been observed that the effectiveness of antibacterial agents is greatly determined by their size [8,9] . The significant specific surface area of nanomaterials enables them to grab microbes and increases interaction with microbial membranes, which enhances the antibacterial characteristics of nanomaterials [10] .…”

Section: Introductionmentioning

confidence: 99%

“…[6,7] Primarily it has been observed that the effectiveness of antibacterial agents is greatly determined by their size. [8,9] The significant specific surface area of nanomaterials enables them to grab microbes and increases interaction with microbial membranes, which enhances the antibacterial characteristics of nanomaterials. [10] Additionally, nanomaterials have distinct physicochemical properties that can either completely deactivate microbes through interaction with the nanomaterials or through their catalytic processes which destroy the microbe.…”

Section: Introductionmentioning

confidence: 99%

Effect of Zn Doping on Antibacterial Efficacy of CuO Nanostructures

Bhosale,

Moyo

et al. 2023

ChemistrySelect

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Bacterial diseases are causing major health issues across the world. Recent research has revealed that the metal ion discharge of nanomaterials is extremely effective at eradicating bacterial outbreaks and resistance. Reactive oxygen species (ROS) for antibacterial functions have been produced using nanomaterials with high specific surface area, complex structural framework, and spectral properties. In this study, we thoroughly investigated the impact of Zn dopants on copper oxide (CuO) nanostructures and their nanomaterial‐based antibacterial processes. The method of production includes the formation of CuO and Zn‐doped CuO nanostructures via chemical coprecipitation. By using several characterization techniques, the as‐synthesized nanostructures were confirmed. Based on their specific surface area and surface‐active site, the different antibacterial activities of these dopants vary the antibacterial action. The antibacterial activity was evaluated using the agar well diffusion method. A significant antibacterial action was observed in the samples. In the pharmaceutical and food sectors, this CuO and its combined dopants can be a substitute for synthetic antibacterial agents.

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A comparative study of antimicrobial activity of differently-synthesized chitosan nanoparticles against bovine mastitis pathogens

Abstract: The greatest concern in dairy farming nowadays is bovine mastitis (BM), which results mainly from bacterial colonization of the mammary gland. Antibiotics are the most widely used strategy for its...

Cited by 15 publications

References 64 publications

Alternatives to Antimicrobial Treatment in Bovine Mastitis Therapy: A Review

Alternatives to Antimicrobial Treatment in Bovine Mastitis Therapy: A Review

The Antimicrobial Applications of Nanoparticles in Veterinary Medicine: A Comprehensive Review

Effect of Zn Doping on Antibacterial Efficacy of CuO Nanostructures

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