A Comparative Study of Antimicrobial and Pharmacological Properties of Argemone  mexicana, Solanum xanthocarpum and Thevetia peruviana

Jaiswal, Jyotsna; Sharma, Bechan

doi:10.31080/asmi.2020.03.0524

Cited by 7 publications

(6 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although some studies have been conducted to better understand these compounds and the biological activities of A . mexicana (reviewed in [ 31 , 32 ]), the phytochemicals possessing many of these biological activities have not yet been identified. Thus, this plant possesses great potential for the discovery of novel antibiotic and anticancer compounds.…”

Section: Introductionmentioning

confidence: 99%

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

et al. 2021

View full text Add to dashboard Cite

Commonly called the Mexican prickly poppy, Argemone mexicana is a stress-resistant member of the Papaveraceae family of plants that has been used in traditional medicine for centuries by indigenous communities in Mexico and Western parts of the United States. This plant has been exploited to treat a wide variety of ailments, with reported antimicrobial and antioxidant properties, as well as cytotoxic effects against some human cancer cell lines. Due to its various therapeutic uses and its abundance of secondary metabolites, A. mexicana has great potential as a drug discovery candidate. Herein, the germination conditions of A. mexicana are described and the cytotoxic activities of different parts (seeds, leaves, inner vs. outer roots) of the plant from methanol or hexane extracts are preliminarily characterized against cells of seven unique organisms. When comparing 1 mg of each sample normalized to background solvent alone, A. mexicana methanol outer root and leaf extracts possessed the strongest antimicrobial activity, with greatest effects against the Gram-positive bacteria tested, and less activity against the Gram-negative bacteria and fungi tested. Additionally, using the MTT colorimetric assay, the outer root methanol and seed hexane extracts displayed pronounced inhibitory effects against human colon cancer cells. Quantification of c-MYC (oncogene) and APC (tumor suppressor) mRNA levels help elucidate how the A. mexicana root methanol extract may be affecting colon cancer cells. After ultra-performance liquid chromatography coupled with mass spectrometry and subsequent nuclear magnetic resonance analysis of the root and leaf methanol fractions, two main antibacterial compounds, chelerythrine and berberine, have been identified. The roots were found to possess both phytocompounds, while the leaf lacked chelerythrine. These data highlight the importance of plants as an invaluable pharmaceutical resource at a time when antimicrobial and anticancer drug discovery has plateaued.

show abstract

Section: Introductionmentioning

confidence: 99%

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

et al. 2021

View full text Add to dashboard Cite

show abstract

“…These phytochemicals consist of alkaloids, flavonoids, saponins, and tannins. The alkaloids of S. xanthocarpumare divided into two groups -the tropane alkaloids and the steroidal alkaloids 139 . The tropane alkaloids are the most abundant and include scopolamine (Figure 25), hyoscyamine (Figure 26), and atropine.…”

Section: Phytochemical Constituents and Its Medicinal Propertiesmentioning

confidence: 99%

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

T. Dhanya,

Kavinila,

David Paul Raj

2024

JNR

View full text Add to dashboard Cite

Snakebite is a significant public health concern in many parts of the world, particularly in regions where venomous snakes are prevalent. Snakebites can range from mild to life-threatening, depending on the species of snake, the amount of venom injected, and the location of the bite. Globally, an estimated 5 million people are affected by snake bites each year, according to recent statistics. Since ancient times, traditional medicinal plants have been used to cure a wide range of illnesses, including snake bites. Secondary metabolites contained in plants were efficient in reducing the effects of snake venom. Snake venom is a potent toxin that can cause severe damage to the human body, affecting the nervous system, cardiovascular system, or both. Symptoms can range from mild swelling to life-threatening paralysis, respiratory failure, and hemorrhage. Enzyme activity is inhibited by flavonoids, alkaloids, and tannins, which additionally hinder blood from clotting and lessen inflammation. Treatments for snake bites that are more beneficial and less hazardous could result from the isolation and synthesis of natural drugs. With the use of cutting-edge scientific methods, we can maximize their potential and use their secondary metabolites to develop novel medications and therapies. The study of these plants and their potential uses in contemporary medicine requires more funding and investigation. This will advance our knowledge of these plants and help us create cures for some of the most lethal diseases.

show abstract

“…Every part of Argemone Mexicana L. possesses so many medicinal properties, either in small or large proportion. However, different parts of the plant contain same or different active ingredients (Chopra et al, 1956, Jaiswal & Sharma, 2020; Alagesaboopathy & Kalaiselvi, 2012). Most of the bioactive compounds are quite harmless whereas toxicity has been evaluated in Argemone oil (Upreti et al, 1989).…”

Section: Medicinal and Pharmacological Applicationsmentioning

confidence: 99%

The Study of Phytochemical Constituents and Medicinal Applications of Argemone Mexicana L

2024

IJFMR

View full text Add to dashboard Cite

Many plants are considered wild or weed with no economical value, Argemone Mexicana L. is one such widely growing neglected weed in almost all the regions of India. Argemone Mexicana L. belongs to the family papaveraceae, also known as the poppy family, including 44 genera and approximately 460 species of flowering plants. Argemone Mexicana L. (Mexican poppy), commonly known as “Satyanasi” in India, is a valuable medicinal plant and considered to have miraculous therapeutic potential. It is used to cure several diseases in the Indian traditional medicine system of Ayurveda for over 5000 years. The leaves, stem, latex, roots and seeds of Argemone Mexicana L. have several pharmacological activities. Many of the phytochemical compounds obtained from the Argemone seeds are especially effective in the treatment of chronic diarrhea, dysentery, peptic ulcers, as well as respiratory infections. . In this study, many medicinal applications, phytochemical constituents and some hazardous effects of this plant has been highlighted.

show abstract

A Comparative Study of Antimicrobial and Pharmacological Properties of Argemone mexicana, Solanum xanthocarpum and Thevetia peruviana

Cited by 7 publications

References 3 publications

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

Characterizing the cytotoxic effects and several antimicrobial phytocompounds of Argemone mexicana

Venom Vanquish: A Comprehensive Review on Ethnobotany and Phytochemistry of Significant Traditional Medicinal Plants

The Study of Phytochemical Constituents and Medicinal Applications of Argemone Mexicana L

Contact Info

Product

Resources

About