Abstract:where the costimulatory signal is provided in trans on accessory proteins that associate with the antigen binding chain via transmembrane interactions. Methods: Several CD3f-containing CAR chains were designed using the transmembrane and cytoplasmic domains of NKG2D or NKp44, associating with DAP10 and DAP12 respectively. Each CAR contained a B7H6-targeting scFv and was co-expressed with corresponding accessory protein using a 2A site. Primary human T cells engineered with the diverse constructs were screened … Show more
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