A Comparative Study Between Spray-Drying and Fluidized Bed Coating Processes for the Preparation of Pramipexole Controlled-Release Microparticles for Orally Disintegrating Tablets

Abstract

In the present study, controlled-release microparticles for orally disintegrating tablets (ODT) were prepared using two different processes, spray drying and fluidized bed coating processes. Pramipexole dihydrochloride monohydrate (PRM), an anti-Parkinson's disease agent, was selected as a model drug. The in vitro release rate and morphology of microparticles were evaluated and compared. The size of microparticles prepared by spray drying (SD microparticles) and fluidized bed coating (FC microparticles) was around 10 and 200 lm, respectively. The latter size was defined by the size of an inert core bead. The release behavior of SD microparticles was characterized by a large initial burst release prior to slow release. In the case of FC microparticles, the initial burst release was smaller than that of SD microparticles and the compression process damaged the releasecontrolling layer, which led to a change in release rate. The results indicated the importance of carefully considering the manufacturing process for microparticles during the design of controlled-release ODT.

Micro- and nano-encapsulated metal and alloy-based phase-change materials for thermal energy storage

“…66 Typical physical techniques include spray drying, uid-bed coating, and electrostatic encapsulation. 61,[80][81][82] Among three methods for PCM encapsulation, polymerisation can provide uniform coating (in situ polymerisation), which is versatile in particle size and cost effective with good size control for PCMs. 66 The method has been applied for organic PCMs, which results in particle size of 1-4000 mm.…”

Formulation and in vitro evaluation of pramipexole orally disintegrating tablets for pediatric restless leg syndrome

“…It can help to minimize the difficulty of treatment on patients and caregivers due to its easy administration. It has been demonstrated in numerous studies that patients prefer ODTs to conventional tablets [19,20]. ODTs can be prepared by various methods as reported in the literature [15][16][17].…”

The Value of Bead Coating in the Manufacturing of Amorphous Solid Dispersions: A Comparative Evaluation with Spray Drying

“…Moreover, only a few studies have compared bead coating with other solid dispersion preparation techniques, which implies that its potential value within the ASD formulation platform is still unclear. For example, Kim et al made a comparative assessment between bead coating and spray drying for the preparation of controlled-release microparticles in orally disintegrating tablets, mainly directing in vitro drug dissolution [ 16 ]. Concerning ASDs, bead coating has been compared with hot melt extrusion by Verreck et al; however, the authors merely focused on drug release and bioavailability [ 17 ].…”