A comparative study between olive oil and corn oil on oxidative metabolism

Drehmer, Eraci; Navarro-Moreno, Mari Ángeles; Carrera-Juliá, Sandra; Sancho, Mari Luz Moreno

doi:10.1039/d2fo00919f

Cited by 5 publications

(3 citation statements)

References 78 publications

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“…Meantime, vegetable oils like coconut oil possess 90% of medium chain saturated fats (like, lauric acid), which differ from animal saturated fats; they are easily absorbed in small intestine and do not undergo degradation or re-esterification [ 25 ]. Olive oil and corn oil possess a lipid source respectively of monounsaturated and polyunsaturated fatty acids [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of various dietary lipids on amelioration of biomarkers linked to metabolic syndrome in both healthy and diabetic Wistar rats

Abudigin,

Bajaber,

Subash-Babu

2024

BMC Nutr

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Background The present study was designed to investigate the influence of different dietary lipids (sheep’s fat, olive oil, coconut oil, and corn oil) on specific biomarkers associated with metabolic syndrome in both healthy and diabetic rats. Methods The study designed for 45 days, utilized a male diabetic wistar rat (body weight, 180–220 g) model induced by streptozotocin (45 mg/kg bw). The rats were divided into two sections: five non-diabetic and five diabetic groups, each containing six rats. The first group in each section serving as the control, received a standard diet. Both non-diabetic or diabetic groups, were provided with a standard diet enriched with 15% sheep fat, 15% coconut oil, 15% olive oil, and 15% corn oil, respectively for a duration of 45 days. Results Post-supplementation, both healthy and diabetic control rats exhibited a higher food intake compared to rats supplemented with lipid diet; notably food intake was higher in diabetic control than healthy control. However, rats fed with coconut oil, olive oil and sheep fat showed weight gain at the end of the experiment, in both healthy and diabetic groups. Coconut oil supplementation significantly (p ≤ 0.05) increased HDL-C and total cholesterol level in diabetic groups compared to healthy group, it was confirmed by an increased PPAR-α and ABCA-1 protein level. Olive oil significantly decreased triglyceride, total cholesterol, and LDL-C levels in diabetic rats when compared to sheep fat or coconut oil. Corn oil significantly decreased fasting glucose, total cholesterol and LDL-C levels compared to all other groups. Corn and olive oil supplemented normal groups, found with significant increase in hepatic glucose-lipid oxidative metabolism associated protein, like FGF-21, MSH, ABCA-1, PPAR-γ and decreased lipogenesis proteins like, SREBP and PPAR-α levels. In contrast, sheep grease and coconut oil increased SREBP and PPAR-α expression in both normal and diabetic groups. Most notably, normal and diabetic groups pretreated with sheep grease resulted in increased inflammatory (MCP-1, IL-1β, TLR-4, TNF-α), and oxidative stress markers (LPO, GSH, GPx, SOD and CAT) linked with metabolic complications. Conclusion The combination or alternative use of olive oil and corn oil in daily diet may play a significant role in preventing proinflammatory condition associated with insulin resistance and cardiovascular diseases.

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Section: Discussionmentioning

confidence: 99%

Impact of various dietary lipids on amelioration of biomarkers linked to metabolic syndrome in both healthy and diabetic Wistar rats

Abudigin,

Bajaber,

Subash-Babu

2024

BMC Nutr

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“…Epidemiological studies have demonstrated that olive oil is rich in antioxidants, which can help prevent oxidative stress, which contributes to the development of diseases such as CVD, cancer, and neurodegenerative diseases [57,74,75]. Olive oil phenols are potent antioxidants because of their capacity to scavenge ROS produced by oxidative stress and stimulate the activity and synthesis of antioxidant enzymes.…”

Section: Olive Oil and The Animal Studies On Its Antioxidant Propertiesmentioning

confidence: 99%

Zebrafish Model Insights into Mediterranean Diet Liquids: Olive Oil and Wine

Silva,

Rodríguez-Pérez,

Burgos-Ramos

2023

Antioxidants

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In this review, we explored the potential of a zebrafish model to investigate the antioxidant effects of key components of the Mediterranean diet, namely, olive oil and wine, in the context of preventing age-related diseases, particularly cardiovascular conditions. This paper explores the spectrum of observational studies to preclinical investigations and ultimately converges toward potential translational insights derived from animal experimentation. This review highlights the potential and underutilization of zebrafish as an experimental model in this domain. We highlighted the genetic proximity of zebrafish to humans, offering a unique opportunity for translational insights into the health benefits of olive oil and wine. Indeed, we wanted to focus on the potential of zebrafish to elucidate the health benefits of olive oil and wine while calling for continued exploration to unlock its full potential to advance our knowledge of age-related disease prevention within the Mediterranean diet framework.

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“…In other words, it does not exert undesirable effects on the body, but it may mask the toxic effects of the compound. Corn oil is also a vegetable oil, and comparisons with olive oil have frequently been reported (Gao et al, 2019;Drehmer et al, 2022). Corn oil does not exhibit antioxidant properties and has not been shown to differ from olive oil as a subcutaneously administered vehicle (Wu et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

Toxicological effects of repeated subcutaneous administration of corn oil for 4 weeks in rats

Moroki

Akizawa

Kondo

et al. 2023

Fundam. Toxicol. Sci.

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In toxicity studies, it is important to select a vehicle that does not affect the toxicity assessment of the test substance. To obtain toxicity information on corn oil as a Vehicle for subcutaneous toxicity studies of non-aqueous test substances, Crl:CD (SD) rats (6 animals/sex/group) were repeatedly dosed with corn oil at 0 (negative control; saline), 1, 2 and 5 mL/kg/day for 4 weeks. High body weight due to retention of the administered substance were found in corn oil groups in both sexes at 2 mL/kg/day or higher. Some relative organ weights at 2 mL/kg/day or higher were decreased due to high body weight or body weight gain. Subcutaneous retention of the administered substance found in all corn oil-treated groups at necropsy was observed on histopathological analysis as accumulation of the administered substance and granulation tissue. Accumulation of the administered substance in inguinal skin, the axillary lymph node, and alveolus of the lung and bronchus was observed. Multiple white nodules in the abdominal cavity and liver observed in a female at 5 mL/kg/day at necropsy were considered to be related to lipogranuloma at the peritoneum and hepatic capsule. In hematology, RBC was lower in females at the 5 mL/kg/day than in the control group.. In conclusion, since the effects of corn oil administration were found in groups at all volumes, it is necessary to take into account that corn oil induces these changes when used as a vehicle of a test substance in toxicity studies.

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A comparative study between olive oil and corn oil on oxidative metabolism

Abstract: Fats are an important part of diet, but not all lipids have the same structure and chemical properties.

Cited by 5 publications

References 78 publications

Impact of various dietary lipids on amelioration of biomarkers linked to metabolic syndrome in both healthy and diabetic Wistar rats

Impact of various dietary lipids on amelioration of biomarkers linked to metabolic syndrome in both healthy and diabetic Wistar rats

Zebrafish Model Insights into Mediterranean Diet Liquids: Olive Oil and Wine

Toxicological effects of repeated subcutaneous administration of corn oil for 4 weeks in rats

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