A Comparative Study between C-Reactive Protein and Procalcitonin in Iraqi Burn Patients

Abstract

Association between Procalcitonin (PCT) and C-reactive protein (CRP) and burn injury was evaluated in 80 burned patients from Al-Kindy and Imam Ali hospitals in Baghdad-Iraq. Patients were divided into two groups, survivor group 56 (70%) and non-survivor group 24 (30%). PCT was estimated using (Human Procalcitonin ELISA kit) provided by RayBio/USA while CRP was performed using a latex agglutination kit from Chromatest (Spain). Our results declared that the mean of Total Body Surface Area (TBSA %) affected were 63.5% range (36% 95%) in non-survivor patients, while 26.5% range (10% 70%) in survivor patients. There is a significant difference between the two groups (P = 0.00), the higher mean percentage of TBSA has a significant association with mortality. Serum PCT and CRP were measured at the three times of sampling (within the first 48hr following admission, after 5 th days and after 10 th days). The mean of PCT serum concentrations in non-survivor group (2638 ± 3013pg/ml) were higher than that of survivor group (588 ± 364pg/ml). Significantly high levels of CRP were found between the survivor and non-survivor groups especially in the 10 th day of admission P=0.000, present study show that significant differences is found within the non-survivor group through the three times P= 0.01, while results were near to significant differences within survivor group through the three times (P= 0.05).

The effectiveness of the psychosocial empowerment program in early adjustment among adult burn survivors

“…The sample size of 40 participants per group was determined based on a power analysis, which indicated that this number was sufficient to detect significant effects given the specific parameters and expected effect size of our research. Although this sample size is slightly smaller than the 45 to 50 participants utilized in related studies [ 45 , 46 ], it aligns with the general scale of previous research in this area. This clarification ensures a more accurate representation of our methodological approach and its alignment with established research standards in the field.…”

Association of inflammatory biomarkers with overall survival in burn patients: a systematic review and meta-analysis

“…Among the 24 included studies [ 43 – 66 ], 16 had retrospective designs [ 43 – 46 , 48 – 50 , 53 , 56 , 59 , 60 , 62 – 66 ]. Studies were conducted in Turkey( n = 5) [ 45 , 49 , 50 , 62 , 64 ], South Korea( n = 2) [ 58 , 60 ], Portugal( n = 1) [ 53 ], Iraq( n = 2) [ 52 , 57 ] Uruguay( n = 1) [ 43 ], India( n = 2) [ 44 , 63 ], Indonesia( n = 1) [ 47 ], China( n = 5) [ 46 , 56 , 59 , 65 , 66 ], USA ( n = 1) [ 55 ], France( n = 1) [ 54 ], Italy ( n = 1) [ 61 ], Germany ( n = 1) [ 51 ], and Sweden( n = 1) [ 48 ]. Ten studies reported in-hospital mortality [ 43 – 45 , 47 , 51 , 54 , 59 , 62 – 64 ], three reported 90- day mortality [ 46 , 56 , 60 ], one reported 51-day mortality [ 65 ] and one reported 28-day mortality [ 66 ].…”

“…Five studies assessed PCT level of patients at time of admission to the hospital [ 53 , 57 , 63 , 65 , 66 ], one study assessed it after informed consent [ 54 ], one reported it on Day 3 [ 51 ], one in the first 48 h after admission [ 62 ], one within 48 h after injury [ 59 ], one in less than 6 h after admission [ 52 ], and one study did not report this data [ 58 ] (Tables 1 and 2 ).…”