A comparative split-face study of photodynamic therapy with indocyanine green and indole-3-acetic acid for the treatment of acne vulgaris

Jang, Min Soo; Doh, Ki-Seung; Kang, Jin Seuk; Jeon, Young Seung; Suh, Kee Suck; Kim, S.T.

doi:10.1111/j.1365-2133.2011.10472.x

Cited by 49 publications

(24 citation statements)

References 42 publications

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“…This study made a good effect, and only produced slight erythema (634) and pruritus (834) after each irradiation, which was relieved within a few hours. 21 …”

Section: Discussionmentioning

confidence: 99%

A new optical intra-tissue fiber irradiation ALA-PDT in the treatment of acne vulgaris in rabbit model: improved safety and tolerability

Wang

Jiang

Liu

et al. 2017

An. Bras. Dermatol.

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BackgroundPhotodynamic therapy with topical aminolevulinic acid (ALA-PDT) has been suggested to be effective in treatment of acne vulgaris. However, adverse events occur during and after treatment.ObjectivesTo compare the efficacy and tolerability of optical intra-tissue fiber irradiation (OFI) ALA-PDT versus traditional ALA-PDT in treatment of acne vulgaris in rabbit models.MethodsTwenty-five rabbits of clean grade were used. Twenty rabbits were randomly selected to establish acne model and the other five were used as control. Rabbits in model group (40 ears) were further divided into four groups (10 ears/group): I, OFI-ALA-PDT with the head of optical fiber inserted into the target lesion (intra-tissue); II, traditional ALA-PDT group; III, OFI group; IV, blank control group without any treatment. Uncomfortable symptoms, adverse events, and effectiveness rates were recorded on post-treatment day 14, 30, and 45.ResultsOn post-treatment day 14, the effectiveness rate in OFI-ALA-PDT group was obviously higher than that of the other three groups (P<0.05). However, no improved effects were observed in OFI-ALA-PDT group on day 30 and 45. During the period of treatment, the frequencies of uncomfortable symptoms in ALA-PDT group were obviously higher than those in the other three groups (P<0.05). The adverse event rate in OFI-ALA-PDT group was obviously lower than that of the ALA-PDT group (P<0.05).Study limitationsThe unblindness of the study and temporary animal models of acne induced may hamper the assessment and monitoring of the results, and future studies are still needed to clarify it further.ConclusionThe OFI-ALA-PDT group (intra-tissue irradiation) showed no improved efficacy on treating rabbit ear acne but had higher safety and better tolerability.

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“…This study made a good effect, and only produced slight erythema (634) and pruritus (834) after each irradiation, which was relieved within a few hours. 21 …”

Section: Discussionmentioning

confidence: 99%

A new optical intra-tissue fiber irradiation ALA-PDT in the treatment of acne vulgaris in rabbit model: improved safety and tolerability

Wang

Jiang

Liu

et al. 2017

An. Bras. Dermatol.

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“…Other topical photosensitizers, which have been studied less extensively, include indocyanine green (or methylene blue) and indole-3-acetic acid 32,33,108–113. Indole-3-acetic acid in particular may have an important role in clinical practice, primarily because patients receiving indole-3-acetic acid for acne experience less pain.…”

Section: Pdt In Inflammatory Diseasesmentioning

confidence: 99%

Current evidence and applications of photodynamic therapy in dermatology

Wan¹,

Lin²

2014

CCID

114

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In photodynamic therapy (PDT) a photosensitizer – a molecule that is activated by light – is administered and exposed to a light source. This leads both to destruction of cells targeted by the particular type of photosensitizer, and immunomodulation. Given the ease with which photosensitizers and light can be delivered to the skin, it should come as no surprise that PDT is an increasingly utilized therapeutic in dermatology. PDT is used commonly to treat precancerous cells, sun-damaged skin, and acne. It has reportedly also been used to treat other conditions including inflammatory disorders and cutaneous infections. This review discusses the principles behind how PDT is used in dermatology, as well as evidence for current applications of PDT.

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“…Here, the reaction of this probe is exploited in a novel way to provide a simple, inexpensive, and convenient measurement of 1 O2 generation from the surface of porphyrin-incorporated photosensitising hydrogels, with the ability to account for effects due to hydrogel porosity. Ingress of the probe into the materials was observed, with rates of up to 3.83 x 10 The high reactivity of photosensitiser-generated singlet oxygen ( 1 O2) has led to its exploitation for photodynamic therapy and photodynamic antimicrobial chemotherapy, and it therefore plays an important role in a number of clinical and antimicrobial treatments and areas of research [1][2][3]. Recently, we have prepared photosensitiserincorporated hydrogels for ocular applications [4].…”

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confidence: 99%

Quantification of singlet oxygen generation from photodynamic hydrogels

Craig

McCoy

Baróid

et al. 2015

Reactive and Functional Polymers

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Recently, we described a series of novel porphyrin-impregnated hydrogels capable of producing microbicidal singlet oxygen ( 1 O2) on photoactivation. Indirect assessment of the efficacy of 1 O2 production from such hydrogels has been previously described using microbiological techniques, but here we report a novel, direct method of quantification. Anthracene-9,10-dipropionic acid (ADPA) is known to irreversibly form an endoperoxide on reaction with 1 O2, causing photobleaching of its absorbance band at approximately 378 nm. Here, the reaction of this probe is exploited in a novel way to provide a simple, inexpensive, and convenient measurement of . This work demonstrates a simple and straightforward method for direct 1 O2 quantification from porous materials, with general utility.

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A comparative split-face study of photodynamic therapy with indocyanine green and indole-3-acetic acid for the treatment of acne vulgaris

Abstract: Both PDT with ICG and PDT with IAA are safe and effective for the treatment of mild to moderate acne vulgaris.

Cited by 49 publications

References 42 publications

A new optical intra-tissue fiber irradiation ALA-PDT in the treatment of acne vulgaris in rabbit model: improved safety and tolerability

A new optical intra-tissue fiber irradiation ALA-PDT in the treatment of acne vulgaris in rabbit model: improved safety and tolerability

Current evidence and applications of photodynamic therapy in dermatology

Quantification of singlet oxygen generation from photodynamic hydrogels

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