A comparative review on silk fibroin nanofibers encasing the silver nanoparticles as antimicrobial agents for wound healing applications

Khan, Rumysa Saleem; Rather, Anjum Hamid; Wani, Taha Umair; Rather, Sami‐ullah; Abdal‐hay, Abdalla; Sheikh, Faheem A.

doi:10.1016/j.mtcomm.2022.103914

Cited by 18 publications

(11 citation statements)

References 128 publications

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“…In this light and in view of the possible application of these grafted silk fibroins as biomaterials with enhanced anti-microbial properties, their silver adsorption ability was evaluated. In fact, silver-loaded silk membranes have already been described as anti-microbial wound dressing [ 26 , 27 , 28 , 29 ]. Moreover, the bioactivity of the grafting fibers (i.e., their calcium phosphate nucleation ability) was evaluated in vitro by ageing studies in simulated body fluid (SBF), mimicking the composition of human plasma [ 5 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Vibrational Study on the Structure, Bioactivity, and Silver Adsorption of Silk Fibroin Fibers Grafted with Methacrylonitrile

2023

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Natural fibers have received increasing attention as starting materials for innovative applications in many research fields, from biomedicine to engineering. Bombyx mori silk fibroin has become a material of choice in the development of many biomedical devices. Grafting represents a good strategy to improve the material properties according to the desired function. In the present study, Bombyx mori silk fibroin fibers were grafted with methacrylonitrile (MAN) with different weight gains. The potential interest in biomedical applications of MAN functionalization relies on the presence of the nitrile group, which is an acceptor of H bonds and can bind metals. IR and Raman spectroscopy were used to characterize the grafted samples and the possible structural changes induced by grafting. Afterward, the same techniques were used to study the bioactivity (i.e., the calcium phosphate nucleation ability) of MAN-grafted silk fibroins after ageing in simulated body fluid (SBF) for possible application in bone tissue engineering, and their interaction with Ag+ ions, for the development of biomaterials with enhanced anti-microbial properties. MAN was found to efficiently polymerize on silk fibroin through polar amino acids (i.e., serine and tryptophan), inducing an enrichment in silk fibroin-ordered domains. IR spectroscopy allowed us to detect the nucleation of a thin calcium phosphate layer and the uptake of Ag+ ions through the nitrile group, which may foster the application of these grafted materials in biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Vibrational Study on the Structure, Bioactivity, and Silver Adsorption of Silk Fibroin Fibers Grafted with Methacrylonitrile

2023

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“…[19][20][21] However, due to the insulating properties of silk, regenerated silk fibroin films tend to be rigid, brittle, and low-viscosity, which limits their application in flexible electronics. Therefore, various conductive materials have been designed to improve their sensing properties, such as carbon nanotubes, [22,23] graphene, [24] silver nanoparticles, [25] etc. combined with it.…”

Section: Introductionmentioning

confidence: 99%

Mass‐Producible 3D Hair Structure‐Editable Silk‐Based Electronic Skin for Multiscenario Signal Monitoring and Emergency Alarming System

Gong

et al. 2023

Adv Funct Materials

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Structurally tunable electronic skin (e‐skin) is beneficial for advancing wearable electronics, prosthetics, and human‐machine interaction (HMI). However, the regulation of e‐skin by traditional nanostructure technology is complex and expensive, moreover, the nanostructure's poor deformability leads to small detection range and low sensitivity. Herein, inspired by the structure of skin‐hair and insect burr, a polypyrrole‐silk/glycerol plasticized silk fibroin (P‐silk/RG) e‐skin fabricated by a simple 3D biomimetic structural strategy is reported. Benefitting from the editability (length, position) of this structure, P‐silk/RG has a signal selectivity, long‐cilia P‐silk/RG demonstrates high sensitivity (respond to weak signal‐airflow), while the short‐cilia P‐silk/RG exhibits wide pressure detection range (0.5–200 g) and high cycle stability (8000 compressions). Therefore, different forms of P‐silk/RG are used in different scenarios (long‐cilia for monitoring breathing and coughing for motion detection and disease diagnosis, short‐cilia for pressure‐sensitive Morse code). Besides, P‐silk/RG exhibits good waterproof, editable conductive points and easy device integration, providing the basis for underwater information transmission, multibit coded command output, and early warning for emergency sports accidents and sedentary. Surprisingly, combining this structure with textile weaving can be mass‐produced. Obviously, this 3D biomimetic structure strategy endows e‐skin with editability and improved scene adaptability to provide a favorable way for mass production.

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“…SF is a naturally occurring polymer and is the main component of the silk cocoon, a potent biomaterial that is widely used in wound healing applications. [ 21 ] It performs excellently in healing wounds because of its low immunogenicity and excellent biocompatibility. It has been readily used in the construction of tissue engineering scaffolds and the making of surgical sutures.…”

Section: Introductionmentioning

confidence: 99%

“…[ 23 ] Moreover, electrospun SF nanofibers have been fabricated as dressing material because of their rapid biodegradation. [ 21 ] The procedure involves the use of formic acid as a solvent after freeze‐drying the SF [ 24 ] and/or the use of an aqueous solvent containing a blend of sacrificial polymer, e.g., poly(ethylene oxide) in SF. [ 25 ] The former involves harsh solvent, which can cause toxicity as solvent leftovers are trapped inside the fibers after electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal Modification of As‐Spun Polyurethane Micro‐Nanofibers Using Silk Fibroin and Biologically Reduced Silver Nanoparticles for Efficient Hydrophilicity and Antibacterial Properties

Khan

Rather

Wani

et al. 2023

Advanced Sustainable Systems

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The hydrophobicity of polyurethane fibers is undesired for tissue engineering. In this work, fibers are fabricated by electrospinning and coated with silk fibroin (SF) for biocompatibility and biologically synthesized silver (Ag) nanoparticles (NPs) for antibacterial activity. The scanning electron microscopy revealed the undistorted morphology and the presence of NPs on fibers. The Fourier transform infrared and thermogravimetric analysis show the successful incorporation of SF and Ag NPs. The water contact angle drops from 101.26±0.2° in pristine to 3.1±0.3° in the hydrothermally treated fibers. The moisture regain from 1.87±0.3% to 6.7±0.4% is observed after 24 h. The mineralization shows the hydroxyapatite NPs in all composites. The large zone of inhibition is observed in the composite, with the Ag NPs equal to 11.5±0.04 mm for Staphylococcus aureus and 18.91±0.02 mm for Escherichia coli. The increased proliferation of HEK 293T cells for 6 days of culture on composite scaffolds compared to the pristine scaffolds is achieved. The cell attachment examinations show successful attachment of cells on fibers and nuclear staining analysis shows the highest proliferation in scaffolds with an intermediate concentration of Ag NPs (10%). This strategy presents a novel improvisation for as‐spun PU fibers that can fabricate wound‐healing biomaterials for tissue engineering.

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A comparative review on silk fibroin nanofibers encasing the silver nanoparticles as antimicrobial agents for wound healing applications

Cited by 18 publications

References 128 publications

Vibrational Study on the Structure, Bioactivity, and Silver Adsorption of Silk Fibroin Fibers Grafted with Methacrylonitrile

Vibrational Study on the Structure, Bioactivity, and Silver Adsorption of Silk Fibroin Fibers Grafted with Methacrylonitrile

Mass‐Producible 3D Hair Structure‐Editable Silk‐Based Electronic Skin for Multiscenario Signal Monitoring and Emergency Alarming System

Hydrothermal Modification of As‐Spun Polyurethane Micro‐Nanofibers Using Silk Fibroin and Biologically Reduced Silver Nanoparticles for Efficient Hydrophilicity and Antibacterial Properties

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