A comparative review of the immunobiology of murine neuroblastoma and human neuroblastoma

Ziegler, Moritz M.; Ishizu, Hideki; Nagabuchi, E; Takada, Naoyuki; Arya, Gajra

doi:10.1002/(sici)1097-0142(19970501)79:9<1757::aid-cncr18>3.3.co;2-h

Cited by 4 publications

(8 citation statements)

References 11 publications

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“…Although murine Neuro-2a neuroblastoma cell line is known for its similarity to human neuroblastoma in biological, physiological, and immunological characteristics [43,44], the behavior of neuroblastoma cells derived from cell lines may differ from that of neuroblastomas in children. Thus, our results cannot easily be transferred to the clinical setting.…”

Section: Discussionmentioning

confidence: 99%

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CO2 pneumoperitoneum increases systemic but not local tumor spread after intraperitoneal murine neuroblastoma spillage in mice

et al. 2008

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Section: Discussionmentioning

confidence: 99%

“…The Neuro-2a murine neuroblastoma cell line (DSMZ, Braunschweig, Germany) is characterized by local and progressive tumor growth, low metastatic potency until the death of the animal [43], and is known for its similarity to human neuroblastoma in biological, physiological, and immunological characteristics [44].…”

Section: Cell Culture and Vitalitymentioning

confidence: 99%

CO2 pneumoperitoneum increases systemic but not local tumor spread after intraperitoneal murine neuroblastoma spillage in mice

et al. 2008

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“…Histologically resembling human NB, metabolizing catecholamines and occasionally regressing spontaneously, it mimics human NB. 16 While C1300 grows locally invasive and spreads to lymph nodes only, the spontaneously arisen subclone TBJ readily metastasizes to liver, adrenal glands, lymph nodes and only rarely to the lung, thus resembling human neuroblastoma. Retroperitoneal inoculation of Neuro-2A, a subclone of C1300, imitates human neuroblastoma better in regard to localization, more invasive growth and metastases to the bone marow.…”

Section: Transplantable Syngeneic Modelsmentioning

confidence: 99%

“…They are similar to human NB in regard to low expression of class I antigens, which can be increased by cytokines, and the cellular and humoral immune response it elicits in the host. 16,[21][22][23] Thus, C1300 and its derivatives have been used for numerous immmune-mediated gene therapy approaches. 19,[21][22][23][24][25][26] C1300 and its derivatives have also been used as models for other gene therapy strategies of NB that depend in part on an immune response, such as suicide gene therapy with herpes simplex virus thymidine kinase/ganciclovir (TK/GCV).…”

Section: Transplantable Syngeneic Modelsmentioning

confidence: 99%

Murine models for experimental therapy of pediatric solid tumors with poor prognosis

Beltinger

Debatin

2001

Int. J. Cancer

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Novel therapeutic strategies are required for pediatric solid tumors with poor prognosis such as metastasizing neuroblastoma, rhabdomyosarcoma and Ewing's sarcoma. A prerequisite for the development of such new therapies is the availability of murine models. To be useful for therapeutic studies, these models should not only recapitulate the genetic alterations characteristic of the human disease but should also mimic the metastatic process and the response to current therapy, both of which ultimately determine the fate of children with these tumors. This review scrutinizes the utility of existing murine models of neuroblastoma, rhabdomyosarcoma and Ewing's sarcoma for investigating novel therapies. Much experience has been gained with both syngeneic and xenogeneic transplantable models of these tumors, while transgenic and knockout mice are just beginning to be available for therapeutic investigations. Modeling the genetic aberrations characterizing these tumors may provide faithful models for therapeutic studies in the future.Key words: mouse model; neuroblastoma; rhabdomyosarcoma; Ewing's sarcoma; therapy In contrast to adults, most children with localized solid tumors can be cured today. However, subsets of pediatric solid tumors still carry a poor prognosis. Besides brain tumors, which will not be considered in this review because of their unique features, these tumors include metastatic neuroblastoma, rhabdomyosarcoma and Ewing's sarcoma. As a paradigm, the dismal prognosis for advanced-stage neuroblastoma has not changed much for decades. While current therapy is largely based on clinical studies of combined chemo-and radiotherapy, the development of new therapies has to rely on clinically relevant murine models of these tumors. This is especially important in pediatric oncology, given the low number of children eligible for phase I trials. 1 The purpose of this review is to discuss the utility of existing murine models of poor-prognosis extracranial pediatric solid tumors for investigating novel therapies. Available mouse models for neuroblastoma, rhabdomyosarcoma and Ewing's sarcoma are reviewed. These tumors have been selected because of their wellcharacterized genetic alterations amenable to mouse modeling and molecular therapeutic strategies. THE "IDEAL" MURINE MODEL OF A SOLID TUMOR FOR THERAPEUTIC RESEARCHThe general limitations of therapeutic research with both transplantable tumor models (syngeneic and xenogeneic) and "spontanously" arising tumors in transgenic or knockout mice have recently been reviewed. 2,3 The characteristics of an "ideal" murine model of a solid tumor have been well defined, as follows:1. Some tumors, especially tumors of childhood, are well described on the genetic level and show characteristic genetic alterations. These changes should obviously be present in the tumor model if the experimental approach targets these changes. However, if the therapy to be tested does not specifically target the etiologic mutation but the ensuing molecular pathology, mouse models that show...

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“…In this model, maturation from malignant neuroblastoma to benign ganglioneuroma may be induced. TBJ-NB is a spontaneously developing clone from C1300-NB, which is able to grow rapidly and invasively with metastatic invasion (20). However, C1300-NB and other models do not genetically recapitulate human disease as no genetic alterations identified in humans are present in these models (21).…”

Section: Syngeneic Animal Modelsmentioning

confidence: 99%

Animal models of extracranial pediatric solid tumors

et al. 2012

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Abstract. Animal models, including xenografts, models of metastatic invasion, syngeneic models and transgenic models, are important tools for basic research in solid pediatric tumors, while humanized animal models are useful for novel immunotherapeutical approaches. Optical and molecular imaging techniques are used for in vivo imaging and may be used in conjunction with alternative treatment approaches, including photodynamic therapy. The aim of this review is to highlight the various animal models that may be used for basic research in pediatric solid tumors.

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A comparative review of the immunobiology of murine neuroblastoma and human neuroblastoma

Abstract: The many similar biologic, physiologic, and immunologic characteristics of human and murine NB make the murine model a valuable adjunctive aid in furthering our understanding of human disease.

Cited by 4 publications

References 11 publications

CO2 pneumoperitoneum increases systemic but not local tumor spread after intraperitoneal murine neuroblastoma spillage in mice

CO2 pneumoperitoneum increases systemic but not local tumor spread after intraperitoneal murine neuroblastoma spillage in mice

Murine models for experimental therapy of pediatric solid tumors with poor prognosis

Animal models of extracranial pediatric solid tumors

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