A Comparative Report on Intracranial Tumor-to-Tumor Metastasis and Collision Tumors

Syed, Sohail; Karambizi, David; Baker, Amanda F.; Groh, Darren; Toms, Steven

doi:10.1016/j.wneu.2018.04.109

Cited by 37 publications

(25 citation statements)

References 139 publications

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“…This interaction is described as the affinity between metastatic tumor cells and the target organ, also known as “cross-talk” [ 3 ]. In fact, the cross-talk between mesothelin, a glycoprotein expressed on the cell membrane, and mucin-16 is thought to play a role in invasion and metastasis in TTM, in which adenocarcinoma, as the donor, metastasizes into meningioma, the recipient [ 23 ]. However, despite a PubMed search performed using the terms “pancreatic neuroendocrine tumor” and “renal cell carcinoma”, the literature regarding the molecular markers that play an important role in metastasis and invasion associated with both terms was not reviewed.…”

Section: Discussionmentioning

confidence: 99%

Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient

et al. 2022

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Background Tumor-to-tumor metastasis is a rare phenomenon in which primary tumor cells metastasize hematogenously into another tumor. Herein, we report an extremely rare case of a renal cell carcinoma metastasis into a pancreatic neuroendocrine tumor exhibiting a tumor-to-tumor metastasis. Ours is the third reported case worldwide. Case presentation The patient, a 72-year-old male, was referred to our hospital for further examination and treatment due to high levels of prostate-specific antigen. A left renal tumor and pancreatic head tumor were revealed incidentally on screening computed tomography. There were suspected to be a renal cell carcinoma and primary pancreatic neuroendocrine tumor or pancreatic metastasis from the renal cell carcinoma according to preoperative examination. The left nephrectomy and subtotal stomach-preserving pancreaticoduodenectomy were performed because of the pancreatic tumor indicated for operation in either case of diagnosis. Postoperative pathological examination showed a diagnosis of clear cell renal cell carcinoma for the left renal tumor. The pancreatic tumor was diagnosed with clear cell renal cell carcinoma metastasis into the pancreatic neuroendocrine tumor, that is to say tumor-to-tumor metastasis. Conclusion In some cases, conservative approach is selected for pancreatic neuroendocrine tumor patients who meet some requirements. However, if such patients exhibit tumor-to-tumor metastasis which combines with renal cell carcinoma and pancreatic neuroendocrine tumor as this case, conservative approach leads to progression of renal cell carcinoma. Therefore, conceiving the possibility of tumor-to-tumor metastasis, it is necessary to carefully choose a treatment plan for pancreatic neuroendocrine tumor patients associated with renal cell carcinoma, not easily choosing conservative approach.

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Section: Discussionmentioning

confidence: 99%

Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient

et al. 2022

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“…In the 1930s, tumor-to-tumor metastasis to meningioma was first recorded by Fried BM (5). Of the total cases reported since, over 70% involved meningiomas, of which nearly half involved breast cancer metastasis (6). The prevalence of this phenomenon is postulated to be partly from the overlapping epidemiology of patients with breast cancer and meningiomas (7).…”

Section: Discussionmentioning

confidence: 99%

Breast carcinoma metastasis in a resected meningioma with early diagnosis of oligometastatic disease: a case report

Fernandez¹,

Cappelli²,

Chapin³

et al. 2020

Chin Clin Oncol

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Tumor-to-tumor metastasis describes the ability of primary tumors to metastasize to other primary tumors. These events generally occur in aggressive and widely-metastatic disease, with the appropriate management and significance of these events unknown. A 56-year-old woman with a history of bilateral, localized, invasive lobular breast carcinoma treated with surgery, systemic therapy, and adjuvant radiation presented five and two years post-treatment with progressive neurological symptoms.Imaging revealed an intracranial meningioma, and the patient underwent resection. Pathology revealed metastatic invasive lobular carcinoma cells within the resected meningioma, and the patient was treated with postoperative radiation without sequelae. Subsequent staging scans revealed a single osseous lesion suggestive of oligometastatic disease, and the patient was promptly started on systemic therapy.

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“…[ 7 – 9 ] To the best of our knowledge, there are fewer than 30 reports of lung carcinoma metastasis to meningioma. [ 3 – 5 , 7 , 10 – 34 ] The epidemiology of TMM is still unknown. From January 2011 to January 2019, there were 2922 consecutive patients diagnosed with meningioma and 540 consecutive patients diagnosed with intracranial metastatic tumor at the Department of Neurosurgery at The First Hospital of China Medical University.…”

Section: Discussionmentioning

confidence: 99%

Metastasis of pulmonary adenocarcinoma to right occipital parafalcine meningioma

Wang

Song

et al. 2020

Medicine

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Rationale: Tumor-to-tumor metastasis is a rare clinical phenomenon. Although meningioma is the most common intracranial recipient of cancer metastasis, only a few cases have been reported. We present a case of metastasis of lung adenocarcinoma into intracranial meningioma and review the published literature. Patient concerns: A 70-year-old woman was admitted to our hospital for a 1-month history of headache and pain in her lower extremities. Diagnosis: Brain and lumbar vertebral magnetic resonance imaging showed an intracranial space-occupying lesion in the right occipital region and spinal canal stenosis. Pulmonary computed tomography showed an irregular mass in the right upper lobe of the lung. The postoperative histological examination demonstrated adenocarcinoma metastasis to meningioma. Intervention: The patient underwent right occipital craniotomy for tumor removal and lumbar spinal canal decompression. Outcomes: There were no initial abnormal conditions after the operation. However, the patient died suddenly 7 days after surgery. Lessons: Tumor-to-meningioma metastasis is a rare but important phenomenon. According to previous reports, it is associated with rapid onset of symptoms and a poor prognosis. Histological examination is of great importance in diagnosis. The history and process of malignant carcinoma should be closely monitored.

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A Comparative Report on Intracranial Tumor-to-Tumor Metastasis and Collision Tumors

Cited by 37 publications

References 139 publications

Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient

Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient

Breast carcinoma metastasis in a resected meningioma with early diagnosis of oligometastatic disease: a case report

Metastasis of pulmonary adenocarcinoma to right occipital parafalcine meningioma

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