A comparative, randomized study of low-dose human menopausal gonadotropin and follicle-stimulating hormone in women with polycystic ovarian syndrome

Sagle, M.; Hamilton‐Fairley, Diana; Kiddy, D.; Franks, Stephen

doi:10.1016/s0015-0282(16)54059-x

Cited by 125 publications

(64 citation statements)

References 18 publications

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“…Low-dose p-FSH regimens are currently the most widely used to achieve ovulation in this population, having a high percentage of monofollicular cycles and a low incidence of OHSS [7,[12][13][14][15][16]. However, the abortion rate in PCOS patients is often high, probably due to high LH levels.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Stimulation with Low-Dose Pure Follicle-Stimulating Hormone in Polycystic Ovarian Syndrome Anovulatory Patients:Effect of Long-Term Pretreatment with Gonadotrophin-Releasing Hormone Analogue

Vegetti

Testa

Ragni

et al. 1998

Gynecol Obstet Invest

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A randomised clinical trial was performed to evaluate the effect of a 3-month gonadotrophin-releasing-hormone analogue (GnRH-a) in one cycle of ovulation induction with low-dose pure follicle-stimulating hormone (pFSH) in patients with polycystic ovarian syndrome (PCOS) anovulation. Twenty patients with chronic anovulation due to PCOS were randomised to ovulation induction with pFSH administered in a low-dose schedule with (10 patients) and without (10 patients) a 3-month pretreatment with GnRH-a. Ultrasound scan only monitoring of follicular growth, evaluation of plasmatic oestradiol at the day of triggering of ovulation with human chorionic gonadotrophin 5,000 IU and evaluation of plasmatic progesterone 8 days after were the main outcome measures. Ovulation occurred in 9 patients treated with pFSH and in 2 patients treated with GnRH-a plus pFSH. Five pregnancies in the pFSH group and no pregnancy in the GnRH-a group were obtained. Five cycles were stopped due to multifollicular growth in the GnRH-a group and 1 in the pFSH group. Pretreatment with a 3-month administration of a GnRH-a did not improve the ovulation rate and pregnancy rate in PCOS patient ovulation induction with low-dose pFSH.

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Section: Discussionmentioning

confidence: 99%

Ovarian Stimulation with Low-Dose Pure Follicle-Stimulating Hormone in Polycystic Ovarian Syndrome Anovulatory Patients:Effect of Long-Term Pretreatment with Gonadotrophin-Releasing Hormone Analogue

Vegetti

Testa

Ragni

et al. 1998

Gynecol Obstet Invest

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“…Zunehmend finden sich in der Literatur Berichte über niedrig dosierte FSH-Stimulation bei clomiphenresistcnten Patientinnen [2,3] …”

Section: T Strowitzki M Korell H Heppunclassified

Sterilitätstherapie bei PCO-Patientinnen

Strowitzki¹,

Korell²,

Hepp³

1991

Gynäkol Geburtshilfliche Rundsch

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“…Attempts have been made using a step-down rather than a step-up protocol (10-12), reduction of the starting dose to 37.5 IU (13) or 52.5 IU (5), the use of hMG rather than FSH (14), or cutting down the initial dose duration of administration from 14-7 days without a change of dose (1). None of these strategies has proved successful in improving results.…”

mentioning

confidence: 99%

Chronic ultra-low dose follicle-stimulating hormone regimen for patients with polycystic ovary syndrome: one click, one follicle, one pregnancy

Orvieto¹,

Homburg²

2009

Fertility and Sterility

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A comparative, randomized study of low-dose human menopausal gonadotropin and follicle-stimulating hormone in women with polycystic ovarian syndrome

Cited by 125 publications

References 18 publications

Ovarian Stimulation with Low-Dose Pure Follicle-Stimulating Hormone in Polycystic Ovarian Syndrome Anovulatory Patients:Effect of Long-Term Pretreatment with Gonadotrophin-Releasing Hormone Analogue

Ovarian Stimulation with Low-Dose Pure Follicle-Stimulating Hormone in Polycystic Ovarian Syndrome Anovulatory Patients:Effect of Long-Term Pretreatment with Gonadotrophin-Releasing Hormone Analogue

Sterilitätstherapie bei PCO-Patientinnen

Chronic ultra-low dose follicle-stimulating hormone regimen for patients with polycystic ovary syndrome: one click, one follicle, one pregnancy

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