A comparative overview of COVID-19, MERS and SARS: Review article

Liu, Jie; Xie, Wanli; Wang, Yanting; Xiong, Yue; Chen, Shiqiang; Han, Jingjing; Wu, Qingping

doi:10.1016/j.ijsu.2020.07.032

Cited by 95 publications

(72 citation statements)

References 113 publications

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“…In the past two decades, three deadly human respiratory syndromes associated with coronavirus (CoV) infections have emerged: severe acute respiratory syndrome (SARS) in 2002, Middle East respiratory syndrome (MERS) in 2012, and COVID-19 in 2019. These three diseases are caused by the zoonotic coronaviruses severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Middle East respiratory syndrome coronavirus (MERS-CoV), and SARS-CoV-2 ( 1 ), respectively. Before their emergence, human coronaviruses were associated with usually mild respiratory illness.…”

mentioning

confidence: 99%

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Gordon

Hiatt

Bouhaddou

et al. 2020

Science

565

703

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The COVID-19 (Coronavirus disease-2019) pandemic, caused by the SARS-CoV-2 coronavirus, is a significant threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and MERS-CoV. Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analysis for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 Orf9b, an interaction we structurally characterized using cryo-EM. Combining genetically-validated host factors with both COVID-19 patient genetic data and medical billing records identified important molecular mechanisms and potential drug treatments that merit further molecular and clinical study.

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mentioning

confidence: 99%

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Gordon

Hiatt

Bouhaddou

et al. 2020

Science

565

703

View full text Add to dashboard Cite

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“…as intermediate host/s [ 11 ]. SARS-CoV-2 is the 7th CoV to be reported in humans, and with respect to novelty, differs from the other important human respiratory CoVs: SARS-CoV and MERS-CoV [ 2 , 3 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Drawing Comparisons between SARS-CoV-2 and the Animal Coronaviruses

Ghosh

Malik

2020

Microorganisms

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The COVID-19 pandemic, caused by a novel zoonotic coronavirus (CoV), SARS-CoV-2, has infected 46,182 million people, resulting in 1,197,026 deaths (as of 1 November 2020), with devastating and far-reaching impacts on economies and societies worldwide. The complex origin, extended human-to-human transmission, pathogenesis, host immune responses, and various clinical presentations of SARS-CoV-2 have presented serious challenges in understanding and combating the pandemic situation. Human CoVs gained attention only after the SARS-CoV outbreak of 2002–2003. On the other hand, animal CoVs have been studied extensively for many decades, providing a plethora of important information on their genetic diversity, transmission, tissue tropism and pathology, host immunity, and therapeutic and prophylactic strategies, some of which have striking resemblance to those seen with SARS-CoV-2. Moreover, the evolution of human CoVs, including SARS-CoV-2, is intermingled with those of animal CoVs. In this comprehensive review, attempts have been made to compare the current knowledge on evolution, transmission, pathogenesis, immunopathology, therapeutics, and prophylaxis of SARS-CoV-2 with those of various animal CoVs. Information on animal CoVs might enhance our understanding of SARS-CoV-2, and accordingly, benefit the development of effective control and prevention strategies against COVID-19.

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“…Based on the most recent epidemiological studies, it is possible to estimate the risk of SARS-CoV-2 infection from some symptoms that differentiate COVID-19 from other causes of FS. In this sense, the most common clinical symptoms associated with COVID-19 are fever (65% to 99%), coughing (22% to 82%), difficulty breathing (17% to 40%) in the most severe cases and muscle pain or fatigue (11% to 44%) [13][14][15]. In addition, loss of smell or taste was observed in about 65% of patients, being the most characteristic symptom of COVID-19, responsible for the increase of 531% to 621% in the risk of testing positive for SARS-CoV-2 [14].…”

Section: Introductionmentioning

confidence: 99%

“…Considering that Brazil is a country of continental dimensions, with great climatic and ethnic diversity plus immense social and regional inequalities, the models derived from hegemonically Asian, European and North American studies [16,15] may not accurately reflect the whole of the most prevalent and influential symptoms to predict contamination by SARS-CoV-2. Currently, both the Instituto Brasileiro de Geografia e Estatística (IBGE), which has been surveying the symptoms of FS in representative samples of the Brazilian population [17], and the Ministry of Health, responsible for coordinating disease notifications in the country, use a European model [14] to assess the probabilities contamination of the population.…”

Section: Introductionmentioning

confidence: 99%

Hierarchy of Covid-19-Related Flu Symptoms According to Sex and Color or Race in Reports of Patients with Severe Acute Respiratory Syndrome in Brazil

Santos

2020

AIR

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The COVID-19 is a disease that presents a wide variety of combinations and intensities of symptoms, characteristic of a Flu Syndrome (FS), which can quickly evolve to a Severe Acute Respiratory Syndrome (SARS). The objectives of this study were to evaluate the hierarchy of symptoms of FS in patients with SARS caused by COVID-19 and to develop a prediction model for potential cases based on sex and race. Binary logistic regression modeling was used in 405,419 records selected from the database of the Ministry of Health of Brazil. It was found that men were more affected by the disease, with a 15.5% higher risk than women. They also died more, with a 13.8% and 15% higher risk for all causes and for COVID-19, respectively. The chances of more than one non-white patient dying from all causes ranged from 18.4% to 38.7% and for Covid-19 it ranged from 16.7% to 64.3% according to race. Fever, muscle pain and loss of smell or taste alternate in the first three positions of the symptom hierarchy, according to sex and race. Cough was only relevant for white men and sore throat for black men. Vomiting was only relevant for black women. The best prediction model developed encompassed seven symptoms adjusted for age, sex and race, but was able to explain only 63% of the cases of COVID-19. Possibly racial diversity, and the socioeconomic inequality associated with it, make the challenge of estimating probabilities of infection by COVID-19, based on symptoms, more complicated in Brazil than in other countries.

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A comparative overview of COVID-19, MERS and SARS: Review article

Cited by 95 publications

References 113 publications

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Drawing Comparisons between SARS-CoV-2 and the Animal Coronaviruses

Hierarchy of Covid-19-Related Flu Symptoms According to Sex and Color or Race in Reports of Patients with Severe Acute Respiratory Syndrome in Brazil

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