A comparative magnetoencephalographic study of cortical activations evoked by noxious and innocuous somatosensory stimulations

Inui, Koji; Tran, Tuan Diep; Qiu, Yunhai; Wang, X; Hoshiyama, Minoru; Kakigi, Ryusuke

doi:10.1016/s0306-4522(03)00261-6

Cited by 143 publications

(103 citation statements)

References 73 publications

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“…We localized 324 dipoles in 23 diVerent cortical areas in both groups. The majority of the dipoles were localized in SI and SII; the SII activation was bilateral, in accordance with the results of previous studies (Forss and Jousmaki 1998;Hari et al 1993;Hoshiyama et al 1996;Inui et al 2003;Kakigi et al 1995;Maeda et al 1999). Interestingly, the ECD counts (i.e.…”

Section: Discussionsupporting

confidence: 91%

Cortical processing of tactile stimuli applied in quick succession across the fingertips: temporal evolution of dipole sources revealed by magnetoencephalography

et al. 2008

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We used magnetoencephalography (MEG) to investigate the cortical processing of an innocuous facial tactile stimulus in healthy subjects and in a group of subjects suVering from chronic temporomandibular disorder (TMD). Equivalent current dipoles (ECDs) were extracted for a time period of 1 s following stimulus application, and their location, duration and onset time determined. The counts of ECDs extracted did not diVer signiWcantly between the two groups. In contrast, we found statistically signiWcant diVerences in ECD duration and onset time. SpeciWcally, ECD duration was longer in the TMD group in the precentral gyrus, and ECD onset time was earlier in the parietal operculum. In addition, we found diVerences in the internal organization and clustering of the brain areas involved indicating a less tight association and a less coordinated stimulus information processing in the TMD group. Altogether, these results show that an innocuous facial tactile stimulus is diVerently processed in the brain of TMD subjects, when compared to controls, reXecting altered brain mechanisms due to chronic pain.

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Section: Discussionsupporting

confidence: 91%

Cortical processing of tactile stimuli applied in quick succession across the fingertips: temporal evolution of dipole sources revealed by magnetoencephalography

et al. 2008

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“…Consequently, in intracranial and extracranial recordings, earliest responses to selective nociceptive stimuli from the hand are typically recorded at ϳ120 ms (Ploner et al, 1999;Kanda et al, 2000;Ohara et al, 2004;Kakigi et al, 2005). Only recently, S1 responses to painful stimuli at latencies of ϳ90 ms have been reported (Inui et al, 2003), but even these latencies cannot explain our present observation of a 60 ms difference in central processing time between modalities. The functional significance of the slow peripheral and spinal conduction velocities of pain has remained unknown.…”

Section: Discussionmentioning

confidence: 58%

Pain Processing Is Faster than Tactile Processing in the Human Brain

Ploner

Groß²,

Timmermann³

et al. 2006

J. Neurosci.

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Pain signals threat and drives the individual into a behavioral response that significantly depends on a short stimulus-response latency. Paradoxically, the peripheral and spinal conduction velocities of pain are much slower than of tactile information. However, cerebral processing times and reaction times of touch and pain have not yet been fully assessed. Here we show that reaction times to selective nociceptive cutaneous laser stimuli are substantially faster than expected from the peripheral conduction velocities. Furthermore, by using magnetoencephalography, we found that latencies between earliest stimulus-evoked cortical responses and reaction times are ϳ60 ms shorter for nociceptive than for tactile stimuli. These findings reveal that cerebral processing of pain is substantially faster than processing of tactile information and relatively compensates for the slow peripheral and spinal conduction velocities of pain. Our observation shows how the cerebral organization of pain processing enhances motor responses to potentially harmful stimuli and thereby subserves the particular behavioral demands of pain.

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“…We have developed a method of intra-epidermal electrical stimulation (IES) for the selective activation of A *Address correspondence to this author at the Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki 444-8585, Japan; Tel: +81 564 55 7811; Fax: +81 564 52 7913; E-mail: ootsuru@nips.ac.jp fibers [11][12][13][14][15][16]. Since this method is easy to control, does not require special equipment, and provides a steep rise of stimulation, it would be good for studying the C fiber nociceptive system if it could activate C fibers selectively.…”

Section: Introductionmentioning

confidence: 99%

Selective Stimulation of C Fibers by an Intra-Epidermal Needle Electrode in Humans

Otsuru

Inui²,

Yamashiro³

et al. 2009

TOPAINJ

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Abstract:We recorded evoked potentials (EPs) induced by intra-epidermal electrical stimulation using a needle electrode with specific parameters. We identified the fibers activated by this specific stimulation by assessing the conduction velocity (CV) of the peripheral nerve. The EPs were recorded from the Cz electrode (vertex) of the International 10-20 system in ten healthy male subjects. The dorsum of the left hand and forearm were stimulated with an intensity of 0.01 mA above the sensory threshold. The mean P1 latency of EPs for the hand and forearm were 1007 ± 88 and 783 ± 80 ms, respectively, and the CV estimated from the latency of P1 was 1.5 ± 0.7 m/s. The CV indicated that the fibers activated by the stimulation were C fibers. Since the method of stimulation is convenient and non-invasive, it should be useful for investigating the functions of small fibers.

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A comparative magnetoencephalographic study of cortical activations evoked by noxious and innocuous somatosensory stimulations

Cited by 143 publications

References 73 publications

Cortical processing of tactile stimuli applied in quick succession across the fingertips: temporal evolution of dipole sources revealed by magnetoencephalography

Cortical processing of tactile stimuli applied in quick succession across the fingertips: temporal evolution of dipole sources revealed by magnetoencephalography

Pain Processing Is Faster than Tactile Processing in the Human Brain

Selective Stimulation of C Fibers by an Intra-Epidermal Needle Electrode in Humans

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