A comparative light-microscopic, electron-microscopic and chemical study of human vaginal and buccal epithelium

Thompson, I O; Bijl, Pieter van der; Wyk, C W van; Eyk, A D van

doi:10.1016/s0003-9969(01)00082-6

Cited by 112 publications

(80 citation statements)

References 17 publications

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“…Previous collaborative studies using ex vivo porcine vaginal tissue suggested that purified TSST-1 alone (concentrations Յ50 g/ml) is unlikely to penetrate the vaginal mucosa in sufficient amounts to cause TSS (13). Porcine vaginal mucosa has a nonkeratinized stratified squamous epithelium and a superficial permeability barrier that is identical in structure and function to that of humans (61). The studies described in this article were initiated in an attempt to characterize the interaction between S. aureus or TSST-1 and HVECs.…”

Section: Discussionmentioning

confidence: 99%

The Innate Immune System Is Activated by Stimulation of Vaginal Epithelial Cells withStaphylococcus aureusand Toxic Shock Syndrome Toxin 1

Ault²,

et al. 2005

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Section: Discussionmentioning

confidence: 99%

The Innate Immune System Is Activated by Stimulation of Vaginal Epithelial Cells withStaphylococcus aureusand Toxic Shock Syndrome Toxin 1

Ault²,

et al. 2005

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“…Recently, HR HPV genotypes have been identified as etiologic agents for a subset of SCCs of oral cavity and oropharynx, especially in non-smoker and non-drinker subjects [114,115]. The hypothesis of the participation of HPV in oral and oropharyngeal carcinogenesis was first proposed by Syrjanen et al [116] and then supported by several other authors [38,65,[117][118][119][120][121] on the basis of the following evidence: a) the epitheliotropic nature of HPV; b) the widely confirmed oncogenic potential of HR gt in the pathogenesis of anogenital neoplasms; and c) the morphological similarities between oropharyngeal and genital epithelia [122]. .…”

Section: Oral Benign Lesions Hpv-relatedmentioning

confidence: 95%

Oral HPV Infection: Current Strategies for Prevention and Therapy

Syrjänen

Termine

Capra³

et al. 2012

CPD

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Infection with High Risk (HR) Human Papillomaviruses (HPVs) is the main aetiological agent of Cervical Squamous Cell Carcinoma (CSCC) and also associated in a subgroup of other neoplasms, including Oropharyngeal Squamous cell Carcinoma (OPSCC). HPV infection, in genital as in oral mucosa, can also be subclinical or associated with benign proliferative lesions (common warts, condylomas, papillomas) caused mostly by infection with Low Risk (LR)-HPVs. In the last decades, extensive research has resulted in growing knowledge on HPV biology and specifically viral life cycle, biochemical properties of viral proteins and their interaction with the host proteins leading to potential new targets of prophylactic or therapeutic vaccines and therapies for HPV infection. In addition, notable progresses have been made in the field of diagnostics to detect HPV DNA or RNA. The recent epidemiological data suggest the significant changes in HPV endemic, due to the changes in sexual habits especially among young generations (i.e. early sexual debuts, multiple sexual partners, oral and anal sex); this scenario has urged on the need of adequate campaigns of primary (sexual education, vaccination programs) and secondary prevention (diagnostics of HPV-related diseases). Due to the growing interest on HPV infection and HPV related cancers, the authors made a narrative review of the literature on oral HPV infection and oral-genital transmission. After this, in view of the controversies about the strategies of therapy and prevention of HPV infection, the present review focuses on the current state of art about the available tools for the therapeutic and, if any, preventive management of oral HPV infection.

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“…Unlike the rest of the external genitalia, the vestibule is derived from embryonic endoderm (the urogenital sinus) and as such, it morphologically resembles the vaginal mucosa. 2 Compared to other areas, vulvar skin is exposed to many more physiologic contact irritants including sweat, vaginal secretions, urine, occlusion (by underwear, sanitary pads, skin-skin contact) and mechanical trauma (from sexual activity, scrubbing, etc.). Because the vulva is almost always covered in some way, the degree of occlusion is a unique factor to consider, and the effects can be significant.…”

Section: Anatomy and Inherent Susceptibilitymentioning

confidence: 99%