A comparative investigation on the in vitro anti-inflammatory, antioxidant and antimicrobial potentials of subextracts from the aerial parts of Daphne oleoides Schreb. subsp. oleoides

Balkan, İrem Atay; Taşkın, Turgut; Doğan, Hacer; Deniz, İnci; Akaydın, Galip; Yeşilada, Erdem

doi:10.1016/j.indcrop.2016.11.038

Cited by 16 publications

(9 citation statements)

References 47 publications

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“…Blank discs (6 mm in diameter) were impregnated with 20 μL of the 1024 μg/mL propolis extracts and located on the inoculated plates. The plates were left to incubation at 37 °C for 18–24 h. The antimicrobial activity of the extracts was determined by measuring the diameter of zone of inhibition in millimeter …”

Section: Methodsmentioning

confidence: 99%

A New Type of Anatolian Propolis: Evaluation of Its Chemical Composition, Activity Profile and Botanical Origin

Degirmencioglu

Güzelmeriç

Yuksel

et al. 2019

Chemistry & Biodiversity

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TurkeyThis study was undertaken to analyze the phenolic profiles of 19 propolis samples from Turkey by using a high-performance thin-layer chromatographic (HPTLC) method in order to identify their plant origins. Furthermore, their antioxidant and antimicrobial activity profiles were comparatively evaluated. For the appraisal of antioxidant potential, total phenolic (TPC) and total flavonoid contents (TFC) of propolis samples were firstly determined and then their effects on free radicals were evaluated by FRAP, ABTS * + , CUPRAC, DPPH * and HPTLC-DPPH * methods. Antimicrobial activity of propolis samples against Staphylococcus aureus (ATCC 6538), Pseudomonas aeruginosa (ATCC 15442), Escherichia coli (ATCC 11229) and Candida albicans ATCC 10231 were determined by disc diffusion and broth dilution methods. HPTLC fingerprinting analyses revealed that O-type (botanical origin from Populus nigra L.) was the primarily available propolis type in Turkey. Moreover, 3-Omethylquercetin (3MQ) rich propolis was identified as a new propolis type for the first time. Principal component analysis (PCA) indicated that 3MQ-type propolis differs from the O-type. Antioxidant activity studies showed that O-type of propolis possesses higher antioxidant effect than the other tested propolis types. Quercetin, caffeic acid, caffeic acid phenethyl ester (CAPE) and galangin were determined to contribute significantly to the antioxidant potential of O-type propolis among others. Propolis extracts exerted moderate antimicrobial activity against the tested microorganisms with MIC values between the ranges of 128-512 μg/mL.

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Section: Methodsmentioning

confidence: 99%

A New Type of Anatolian Propolis: Evaluation of Its Chemical Composition, Activity Profile and Botanical Origin

Degirmencioglu

Güzelmeriç

Yuksel

et al. 2019

Chemistry & Biodiversity

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“…D. oleoides has been already studied for its natural products content and revealed the presence of a wide variety of secondary metabolites belonging to different classes of natural products. Among these were recognized lignan, flavonoids, diterpenoids, steroids, phenylpropanoids, monomeric, dimeric, and trimeric coumarins as aglycones and in glycosidic forms, the most of them were also endowed with interesting biological activities, i.e ., anti‐inflammatory, antioxidant, and antimicrobial, inhibitory toward inflammatory cytokines, wound healing activity, and against rheumatism and malaria . For both these reasons, the wide variety of secondary metabolites and their bioactivities, the studies about the phytochemistry of this species are currently in the limelight.…”

Section: Introductionmentioning

confidence: 99%

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

Venditti

Sanna

Lorenzetti

et al. 2017

Chemistry & Biodiversity

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The phytochemical analysis of the ethanolic extract obtained from D. oleoides collected from Sardinia Island allowed the isolation of several new constituents for the species (3, 8, and 9) together with two new coumarinyl ethers (1 and 2) besides the chemotaxonomic markers of the Daphne genus (4 - 7 and 10) which are also known to possess interesting biological activities. The structure of the new compounds were elucidated by extensive spectroscopic and spectrometric analyses. The identification of these compounds gives an experimental evidence of the variability in the secondary metabolites pattern owned by populations growing in restricted area in respect to populations not confined by geographical barrier.

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“…The results showed significant differences according to the solvent, habitat, and interactions between the solvents and habitats at all levels. In the study, DPPH and ABTS free radical scavenging by the extracts are expressed as IC 50 values, the lower the IC 50 value, the higher the free radical scavenging activity [34]. The leaf extract in methanol performed the best in the DPPH assay (13.93 mg/mL), followed by in water (15.05 mg/mL), ethanol (25.56 mg/mL), and n-hexane (52.36 mg/mL).…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

Comprehensive profiling of phytochemical compounds, antioxidant activities, anti-HepG2 cell proliferation, and cholinesterase inhibitory potential of Elaeagnus mollis leaf extracts

Kong

et al. 2020

PLoS ONE

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The aim of this work was to enrich the knowledge on the potential applications of Elaeagnus mollis leaf extracts. For this purpose, the bioactive compounds (phenolic, flavonoid, alkaloid, proanthocyanidin, chlorophyll and carotene content), antioxidant activity, anti-HepG2 cell proliferation, and cholinesterase inhibitory potential (AChE and BChE) of E. mollis leaves which obtained from different habitats were quantitatively analyzed using various solvents (water, methanol, ethanol, and n-hexane). The results showed that the methanol extracts exhibited the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity and the water extracts showed the best antioxidant activity in the 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) free radical scavenging activity, ferric reducing antioxidant power (FRAP), and reducing power (RP) assays. Moreover, the methanol extracts showed the best inhibitory activity against cholinesterase and HepG2 cancer cells. Correlation analysis revealed that the high antioxidant and anti-HepG2 cell proliferation activities were mainly attributed to the total phenolics, flavonoids, and proanthocyanidins while AChE inhibition was attributed to the total alkaloid and carotene content. The statistical results showed that the effect of habitats was lower than that of different solvents used. Additionally, the metabolic profiles of E. mollis leaves were evaluated using HPLC-ESI-Q TRAP-MS/MS, and a total of 1,017 chemical components were detected and classified into 23 classes. The organic acids and derivatives ranked the first, followed by flavone, amino acid and derivatives, and so on. In conclusion, the effects of different solvents were more significant than the effects of different habitats and the methanol extracts of E. mollis leaves could be used as an effective source of functional active components, provide benefits to physical health care and be applied to the food and pharmaceutical industries.

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A comparative investigation on the in vitro anti-inflammatory, antioxidant and antimicrobial potentials of subextracts from the aerial parts of Daphne oleoides Schreb. subsp. oleoides

Cited by 16 publications

References 47 publications

A New Type of Anatolian Propolis: Evaluation of Its Chemical Composition, Activity Profile and Botanical Origin

A New Type of Anatolian Propolis: Evaluation of Its Chemical Composition, Activity Profile and Botanical Origin

New Coumarinyl Ethers in Daphne oleoides Schreb. Collected from Sardinia Island

Comprehensive profiling of phytochemical compounds, antioxidant activities, anti-HepG2 cell proliferation, and cholinesterase inhibitory potential of Elaeagnus mollis leaf extracts

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