A Comparative Investigation on Bioactivity and Antibacterial Properties of Sol-Gel Derived 58S Bioactive Glass Substituted by Ag and Zn

Shahrbabak, Mohammad Sadegh Nabizadeh; Sharifianjazi, Fariborz; Rahban, Daruosh; Salimi, Ali

doi:10.1007/s12633-018-0063-2

Cited by 51 publications

(27 citation statements)

References 51 publications

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“…This bioglass showed higher in vitro formation of hydroxyapatite than pure and zinc‐substituted glasses. [ 163 ] Ag 2 O‐doped hydroxyapatite has also been used for orthopedic and dental applications as antimicrobial coatings. [ 164 ]…”

Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

441

345

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Microbial colonization on material surfaces is ubiquitous. Biofilms derived from surface-colonized microbes pose serious problems to the society from both an economical perspective and a health concern. Incorporation of antimicrobial nanocompounds within or on the surface of materials, or by coatings, to prevent microbial adhesion or kill the microorganisms after their attachment to biofilms, represents an important strategy in an increasingly challenging field. Over the last decade, many studies have been devoted to preparing meta-based nanomaterials that possess antibacterial, antiviral, and antifungal activities to combat pathogen-related diseases. Herein, an overview on the state-of-the-art antimicrobial nanosized metal-based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets. The antimicrobial mechanism of these nanostructures and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry are discussed. Their properties as well as potential caveats such as cytotoxicity, diminishing efficacy, and induction of antimicrobial resistance of materials incorporating these nanostructures are reviewed to provide a backdrop for future research.

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Section: Metal‐based Nanocompoundsmentioning

confidence: 99%

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Makvandi

Wang

Zare

et al. 2020

Adv Funct Materials

441

345

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“…The sol-gel procedure is a wet chemical technique in which high temperatures or pH values are not required [55,[67][68][69][70] (Fig. 3).…”

Section: Sol-gel Techniquementioning

confidence: 99%

Hydroxyapatite Consolidated by Zirconia: Applications for Dental Implant

Sharifianjazi

Pakseresht

Asl

et al. 2020

jcc

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“…Generally, thermal treatment can cause partial crystallization of bioactive glasses, which corresponds to the enhancement of their mechanical characteristics. However, this crystallization may decrease the bioactivity, since it has been described that the crystalline phases developed by this heating procedure are hardly bioactive . Especially, crystalline phases of the CaO‐SiO 2 ‐MgO system specifically, akermanite (Ca 2 MgSi 2 O 7 ), diopside (CaMgSi 2 O 7 ), and merwinite (Ca 3 MgSi 2 O 8 ) present remarkable apatite forming ability and so may be utilized in the future in biomedical applications .…”

Section: Discussionmentioning

confidence: 99%

“…The incorporation of elemental additives such as alkali, alkaline earth, transition and posttransition metals enhances BGs performance and introduces osteoconductivity, angiogenicity and antibacterial properties . Magnesium (Mg) is the fourth most abundant metal cation in the human body and the second most common intracellular cation and approximately 50%–60% of Mg total content is stored in the skeleton .…”

Section: Introductionmentioning

confidence: 99%

Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity

Moghanian

Ghorbanoghli

Kazem‐Rostami

et al. 2019

Int J of Appl Glass Sci

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In this study, six sol‐gel copper/magnesium substituted derivatives of 58S‐BG, that is, a mol% series of 60SiO2–4P2O5–5CuO–(31–x) CaO/xMgO (where x = 0, 1, 3, 5, 8, and 10), were synthesized as new multifunctional bioactive glasses (BGs). Afterwards, the effect of MgO/CaO substitution on the in vitro formation of nanohydroxyapatite (HA), osteoblast‐like cell responses, and bioactive glasses antibacterial performance were studied. X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) results revealed that Cu‐substituted 58S‐BG consisting of 5 mol% MgO (BG‐5/5) had capability of the formation of HA on its surface while, Cu‐substituted 58S‐BGs consisting 8 mol% and 10 mol% MgO (BG‐5/8 and BG‐5/10) displayed lower bioactivity. The In vitro investigations proved that the highest values of both differentiation and proliferation of MC3T3‐E1 cells can be obtained from a 5 mol% MgO substituted BG. Furthermore, these novel Cu/Mg‐substituted 58S‐BGs displayed antibacterial effect against methicillin‐resistant staphylococcus aureus bacteria. Taken together, the results suggest the equally substituted BG‐5/5 (ie., the one consists of 5 mol% of both CuO and MgO) as a promising candidate for bone tissue engineering, among all newly designed BGs in this work, owing to its desirable cell proliferation, ALP activity, and antibacterial properties.

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A Comparative Investigation on Bioactivity and Antibacterial Properties of Sol-Gel Derived 58S Bioactive Glass Substituted by Ag and Zn

Cited by 51 publications

References 51 publications

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects

Hydroxyapatite Consolidated by Zirconia: Applications for Dental Implant

Novel antibacterial Cu/Mg‐substituted 58S‐bioglass: Synthesis, characterization and investigation of in vitro bioactivity

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