A Comparative Investigation of the Analgesic Effects of Metamizole and Paracetamol in Rats

İnce, İlker; Aksoy, Mehmet; Ahıskalıoğlu, Ali; Çömez, Mehmet Selim; Dostbil, Ayşenur; Çelik, Mine; Yılmaz, İsmayil; Mammadov, Renad; Doğan, Hasan Serkan; Ozgermen, Basak Boztok; Altuner, Durdu

doi:10.3109/08941939.2014.998798

Cited by 21 publications

(20 citation statements)

References 30 publications

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“…However, no correlation between paclitaxel-induced neuropathic pain and MDA, MPO and tGSH levels has been reported in the literature. It has been reported elsewhere that MDA levels increased proportionally in relation to a decrease in the paw pain threshold (20), while Cetin et al (25) observed that MDA decreased in paw tissue with a corresponding increase in pain threshold. In another study, MDA was shown to increase in the presence of neuropathic pain (26).…”

Section: Discussionmentioning

confidence: 98%

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The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

Kuyrukluyıldız¹,

Küpeli²,

Bedir³

et al. 2017

Turk J Anaesth Reanim

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Section: Discussionmentioning

confidence: 98%

“…Analgesic activity (%)=100−[(100×paw pain threshold measured on day 7 after the administration of paclitaxel (g)/paw pain threshold measured after the administration of anakinra (g)] (20).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

Kuyrukluyıldız¹,

Küpeli²,

Bedir³

et al. 2017

Turk J Anaesth Reanim

Self Cite

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“…Furthermore, the amount of MDA has been reported to be elevated both in inflammatory and noninflammatory pains; this suggests that oxidative stress has a role in pain pathogenesis [ 33 ]. Ilker et al stated the importance of oxidative stress in the pathogenesis of incision-related postoperative pain and reported that MPO gene expression increased in damaged tissue that underwent incision; in addition, they demonstrated that metamizol, which significantly inhibited the increase of MPO gene expression, had a more potent analgesic effect than paracetamol, which could not inhibit MPO expression [ 15 ]. SF mucus and DS inhibited increase of MPO activity in the paw as a result of incision, and this suggests that inhibition of the increase of MPO activity is one of the significant analgesic activity mechanisms of SF.…”

Section: Discussionmentioning

confidence: 99%

“…Malondialdehyde (MDA), myeloperoxidase (MPO), nitric oxide (NO), total reduced glutathione (tGSH), superoxide dismutase (SOD), and COX-2 gene expression parameters were measured in the extracted paw tissues. Analgesic activity was calculated by the method of Ince et al [ 15 ]. All results obtained from the experiment were evaluated in comparison with the SIC group (n=6).…”

Section: Experimental Groupsmentioning

confidence: 99%

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Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats

et al. 2016

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No comparative study could be found for the analgesic activity of mucuses from the Oncorhynchus mykiss (OM), Salvelinus fontinalis (SF), Salmo coruhensis (SC), Acipenser gueldenstaedtii (AG), and Acipenser baerii (AB) fish species in the literature. We aimed to investigate the effects of mucuses obtained from the abovementioned fish species on scalpel incision-induced pain in the rat paw and to examine the role of oxidant/antioxidant parameters and COX-2 gene expression in the analgesic activities. Animals were divided into groups: SIC (scalpel incision; SI), SIDS (SI+25 mg/kg diclofenac sodium), SOM (SI+25 mg/kg OM mucus), SFM (SI+25 mg/kg SF mucus), SCM (SI+25 mg/kg SC mucus), SAgM (SI+25 mg/kg AG mucus), SAbM (SI+25 mg/kg AB mucus), and HG (healthy). The paw pain thresholds were measured with a Basile algesimeter before and after diclofenac sodium (DS) or mucus administration, and then the rats were euthanized with thiopental sodium. Oxidant/antioxidant and COX-2 gene expression parameters were measured in paw tissues. OM, SC, AG, and AB fish mucuses could not decrease the SI-induced pain. However, SF fish mucus prevented this pain by 69% after the first hour and by 58.3% after the third hour. DS was shown to suppress pain more weakly than SF, preventing the pain by 62.1% and 50.0% after the first and third hours, respectively. SF mucus and DS significantly inhibited increase of COX-2 gene expression, while other fish mucuses could not. None of the fish mucuses except SF mucus in conjunction with DS could significantly inhibit the increase in oxidant parameters and decrease in antioxidants. SF fish mucus should be comparatively assessed in clinical practice for treatment of postoperative pain.

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Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain

et al. 2020

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Background Treatment of neuropathic pain is still challenging. Recent studies have suggested that dorsal root ganglia (DRG), which carry sensory neural signals from the peripheral nervous system to the central nervous system, are important for pathological nociception. A proper understanding of the significance and function of DRG and their role in pharmacotherapy can help to improve the treatment of neuropathic pain. Metamizole, also known as sulpyrine or dipyrone, is a non-opioid analgesic commonly used in clinical practice, but it is not used for neuropathic pain treatment. Methods Chronic constriction injury (CCI) of the sciatic nerve was induced in Wistar rats. Metamizole was administered intraperitoneally (ip) preemptively at 16 and 1 h before CCI and then twice a day for 7 days. To evaluate tactile and thermal hypersensitivity, von Frey and cold plate tests were conducted, respectively. Results Our behavioral results provide evidence that repeated intraperitoneal administration of metamizole diminishes the development of neuropathic pain symptoms in rats. Simultaneously, our findings provide evidence that metamizole diminishes the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury. These assays indicate, for the first time, that metamizole exerts antinociceptive effects on nerve injury-induced neuropathic pain at the DRG level. Conclusions Finally, we indicate that metamizole-induced analgesia in neuropathy is associated with silencing of a broad spectrum of cytokines in DRG. Our results also suggest that metamizole is likely to be an effective medication for neuropathic pain. Graphic abstract

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A Comparative Investigation of the Analgesic Effects of Metamizole and Paracetamol in Rats

Abstract: Our results show that metamizole is more effective than paracetamol for treating surgical trauma-related pain, inflammation, and oxidative stress and hence may be a preferential drug to paracetamol.

Cited by 21 publications

References 30 publications

The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

Investigation of mucus obtained from different fish species on the acute pain induced with scalpel incision in paw of rats

Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain

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