Abstract-This paper aims at disclosing the influence of computer hypermedia annotations on the incidental vocabulary acquisition of Chinese students in English reading. Firstly, the author defines and explains the basic concepts, and summarizes the development trend of English reading vocabulary teaching. Through several experimental cases, the author discusses the effect of different annotation modes, ranging from English mode, Chinese mode, image mode, noimage mode, to the combination of texts and images, on the students' incidental acquisition of English vocabularies, and analyzes the test results of the experimental cases in light of the characteristics of long-term memory. According to the empirical results, the combination of Chinese annotations and images has better effect than other modes, and plays a positive role in promoting students' incidental vocabulary acquisition.